Summary of Study ST001785

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001134. The data can be accessed directly via it's Project DOI: 10.21228/M8470J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Perform statistical analysis | Show all samples | Show named metabolites | Download named metabolite data
Download mwTab file (text) | Download mwTab file(JSON)

Study ID	ST001785
Study Title	The human lipidome via NMR
Study Summary	The study population includes 844 healthy volunteers of which 183 women and 661 men, with a median age of 43 ± 12 yrs and 40 ± 11 yrs, respectively. The participants in this study were selected from the Tus-cany section of the Italian Association of Blood Donors (AVIS) in the Transfusion Service of the Pistoia Hospital. Plasma samples were obtained according to the Italian guidelines for blood donations. How age and sex influence the human metabolome and lipidome were investigated.
Institute	University of Florence
Department	CERM
Last Name	Vignoli
First Name	Alessia
Address	Via Luigi Sacconi 6
Email	vignoli@cerm.unifi.it
Phone	0554574281
Submit Date	2021-04-26
Analysis Type Detail	NMR
Release Date	2021-05-25
Release Version	1

Select appropriate tab below to view additional metadata details:

Project:

Project ID:	PR001134
Project DOI:	doi: 10.21228/M8470J
Project Title:	Lipidomics on healthy blood donors
Project Summary:	The study population includes 844 healthy volunteers of which 183 women and 661 men, with a median age of 43 ± 12 yrs and 40 ± 11 yrs, respectively. The participants in this study were selected from the Tus-cany section of the Italian Association of Blood Donors (AVIS) in the Transfusion Service of the Pistoia Hospital. Plasma samples were obtained according to the Italian guidelines for blood donations. How age and sex influence the human lipidome were investigated.
Institute:	University of Florence
Department:	CERM
Last Name:	Vignoli
First Name:	Alessia
Address:	Via Luigi Sacconi 6, Sesto Fiorentino, Italia, 50019, Italy
Email:	vignoli@cerm.unifi.it
Phone:	+390554574281
Publications:	Vignoli, A.; Tenori, L.; Luchinat, C.; Saccenti, E. Age and sex effects on plasma metabolite association networks in healthy subjects. Journal of Proteome Research 2018, 17, 97-107. Saccenti, E.; Suarez-Diez, M.; Luchinat, C.; Santucci, C.; Tenori, L. Probabilistic networks of blood metabolites in healthy subjects as indicators of latent cardiovascular risk. Journal of Proteome Research 2014, 14, 1101--1111. Vignoli, A.; Tenori, L.; Luchinat, C.; Saccenti, E. Differential network analysis reveals molecular determinants associated with blood pressure and heart rate in healthy subjects. Journal of Proteome Research 2020.

Subject:

Subject ID:	SU001862
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606
Age Or Age Range:	18-60

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	Gender
SA165375	AVI00325	Female
SA165376	AVI00147	Female
SA165377	AVI00326	Female
SA165378	AVI00551	Female
SA165379	AVI00148	Female
SA165380	AVI00673	Female
SA165381	AVI00669	Female
SA165382	AVI00768	Female
SA165383	AVI00141	Female
SA165384	AVI00599	Female
SA165385	AVI00144	Female
SA165386	AVI00556	Female
SA165387	AVI00235	Female
SA165388	AVI00749	Female
SA165389	AVI00373	Female
SA165390	AVI00745	Female
SA165391	AVI00563	Female
SA165392	AVI00236	Female
SA165393	AVI00392	Female
SA165394	AVI00597	Female
SA165395	AVI00239	Female
SA165396	AVI00476	Female
SA165397	AVI00598	Female
SA165398	AVI00774	Female
SA165399	AVI00535	Female
SA165400	AVI00660	Female
SA165401	AVI00404	Female
SA165402	AVI00538	Female
SA165403	AVI00314	Female
SA165404	AVI00610	Female
SA165405	AVI00798	Female
SA165406	AVI00261	Female
SA165407	AVI00411	Female
SA165408	AVI00532	Female
SA165409	AVI00608	Female
SA165410	AVI00783	Female
SA165411	AVI00252	Female
SA165412	AVI00132	Female
SA165413	AVI00133	Female
SA165414	AVI00371	Female
SA165415	AVI00777	Female
SA165416	AVI00542	Female
SA165417	AVI00781	Female
SA165418	AVI00123	Female
SA165419	AVI00124	Female
SA165420	AVI00125	Female
SA165421	AVI00393	Female
SA165422	AVI00742	Female
SA165423	AVI00201	Female
SA165424	AVI00713	Female
SA165425	AVI00712	Female
SA165426	AVI00224	Female
SA165427	AVI00715	Female
SA165428	AVI00716	Female
SA165429	AVI00337	Female
SA165430	AVI00353	Female
SA165431	AVI00577	Female
SA165432	AVI00198	Female
SA165433	AVI00581	Female
SA165434	AVI00698	Female
SA165435	AVI00343	Female
SA165436	AVI00216	Female
SA165437	AVI00703	Female
SA165438	AVI00702	Female
SA165439	AVI00214	Female
SA165440	AVI00341	Female
SA165441	AVI00209	Female
SA165442	AVI00707	Female
SA165443	AVI00699	Female
SA165444	AVI00212	Female
SA165445	AVI00721	Female
SA165446	AVI00191	Female
SA165447	AVI00690	Female
SA165448	AVI00591	Female
SA165449	AVI00570	Female
SA165450	AVI00733	Female
SA165451	AVI00173	Female
SA165452	AVI00368	Female
SA165453	AVI00799	Female
SA165454	AVI00566	Female
SA165455	AVI00740	Female
SA165456	AVI00738	Female
SA165457	AVI00732	Female
SA165458	AVI00364	Female
SA165459	AVI00228	Female
SA165460	AVI00357	Female
SA165461	AVI00356	Female
SA165462	AVI00355	Female
SA165463	AVI00186	Female
SA165464	AVI00726	Female
SA165465	AVI00571	Female
SA165466	AVI00181	Female
SA165467	AVI00336	Female
SA165468	AVI00574	Female
SA165469	AVI00743	Female
SA165470	AVI00408	Female
SA165471	AVI00494	Female
SA165472	AVI00040	Female
SA165473	AVI00849	Female
SA165474	AVI00451	Female

Showing page 1 of 9 Results: 1 2 3 4 5 Next Last Showing results 1 to 100 of 844

Collection:

Collection ID:	CO001855
Collection Summary:	Plasma samples were obtained according to the Italian guidelines for blood donations restricting donors of age 18−60 years, body weight >50 kg, systolic blood pressure 110−148 mmHg, diastolic blood pressure 60−100 mmHg, absence of (manifested) infectious diseases, absence of chronic diseases, no current menstruation, no consumption of medicines within 1 week before donation (bd), no common diseases (such as flu, cold, bron-chitis) within 2 weeks bd, no surgery within 3 months bd, no endoscopic exams within 4 months bd, no pregnancy within 12 months bd, no abor-tion within 4 months bd, no travel to tropical countries within 6 months bd, and, in particular, no sport activity within 24 h bd. Further details can be found in our previous publications.
Sample Type:	Blood (plasma)
Storage Conditions:	-80℃

Treatment:

Treatment ID:	TR001875
Treatment Summary:	No treatment.

Sample Preparation:

Sampleprep ID:	SP001868
Sampleprep Summary:	Frozen plasma samples were thawed at room temperature and shaken before use (Bernini et al. 2011). A total of 300 μL of a sodium phosphate buffer (10.05 g Na2HPO4·7H2O; 0.2 g NaN3; 0.4 g sodium trimethylsilyl [2,2,3,3-2H4] pro-pionate (TMSP) in 500 mL of H2O with 20% (v/v) 2H2O; pH 7.4) was added to 300 μL of each plasma sample, and the mixture was homogenized by vortexing for 30 seconds. A total of 450 μL of this mixture was transferred to a 4.25 mm NMR tube (Bruker BioSpin srl) for analysis.

Sampleprep ID:

SP001868

Sampleprep Summary:

Frozen plasma samples were thawed at room temperature and shaken before use (Bernini et al. 2011). A total of 300 μL of a sodium phosphate buffer (10.05 g Na2HPO4·7H2O; 0.2 g NaN3; 0.4 g sodium trimethylsilyl [2,2,3,3-2H4] pro-pionate (TMSP) in 500 mL of H2O with 20% (v/v) 2H2O; pH 7.4) was added to 300 μL of each plasma sample, and the mixture was homogenized by vortexing for 30 seconds. A total of 450 μL of this mixture was transferred to a 4.25 mm NMR tube (Bruker BioSpin srl) for analysis.

Analysis:

Analysis ID:	AN002896
Laboratory Name:	CERM
Analysis Type:	NMR
Num Factors:	2
Num Metabolites:	28
Units:	mg/dL

NMR:

NMR ID:	NM000205
Analysis ID:	AN002896
Instrument Name:	Bruker 600 Advanced III
Instrument Type:	FT-NMR
NMR Experiment Type:	1D-1H
Spectrometer Frequency:	600
Temperature:	310