Summary of Study ST001870

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001180. The data can be accessed directly via it's Project DOI: 10.21228/M85T3V This work is supported by NIH grant, U2C- DK119886.

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Study IDST001870
Study TitleEffects of GP130 Antagonism on Right Ventricular Metabolism in Monocrotaline Rats
Study SummaryWe used global metabolomics profiling to evaluate right ventricular metabolism in control, monocrotaline rats treated with vehicle, and monocrotaline rats treated with SC144 (GP130 antagonists).
Institute
University of Minnesota
Last NamePrins
First NameKurt
Address2231 6th St
Emailprin0088@umn.edu
Phone6126257687
Submit Date2021-07-16
Num Groups3
Total Subjects30
Num Males30
Analysis Type DetailLC-MS
Release Date2021-07-26
Release Version1
Kurt Prins Kurt Prins
https://dx.doi.org/10.21228/M85T3V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001180
Project DOI:doi: 10.21228/M85T3V
Project Title:Effects of WNK463 on Right Ventricular Metabolomics in Monocrotaline Rats
Project Summary:We investigated the effects of WNK463 treatment on right ventricular metabolism in monocrotaline-induced pulmonary artery hypertension.
Institute:University of Minnesota
Last Name:Prins
First Name:Kurt
Address:2231 6th St. SE, 4-145
Email:prin0088@umn.edu
Phone:6126257687

Subject:

Subject ID:SU001947
Subject Type:Mammal
Subject Species:Rattus norvegicus
Taxonomy ID:10116
Gender:Male
Animal Animal Supplier:Charles River
Species Group:Mammals

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA174715Control 18Control
SA174716Control 20Control
SA174717Control 12Control
SA174718Control 11Control
SA174719Control 17Control
SA174720Control 19Control
SA174721Control 16Control
SA174722Control 14Control
SA174723Control 15Control
SA174724Control 13Control
SA174725Drug 16MCT-SC144
SA174726Drug 15MCT-SC144
SA174727Drug 11MCT-SC144
SA174728Drug 17MCT-SC144
SA174729Drug 14MCT-SC144
SA174730Drug 12MCT-SC144
SA174731Drug 4MCT-SC144
SA174732Drug 20MCT-SC144
SA174733Drug 19MCT-SC144
SA174734Drug 18MCT-SC144
SA174735Vehicle 12MCT-Vehicle
SA174736Vehicle 9MCT-Vehicle
SA174737Vehicle 8MCT-Vehicle
SA174738Vehicle 7MCT-Vehicle
SA174739Vehicle 10MCT-Vehicle
SA174740Vehicle 11MCT-Vehicle
SA174741Vehicle 16MCT-Vehicle
SA174742Vehicle 14MCT-Vehicle
SA174743Vehicle 13MCT-Vehicle
SA174744Vehicle 15MCT-Vehicle
Showing results 1 to 30 of 30

Collection:

Collection ID:CO001940
Collection Summary:Right ventricular free walls were isolated immediately after dissection and snap frozen in liquid nitrogen.
Sample Type:Heart

Treatment:

Treatment ID:TR001959
Treatment Summary:Control rats, monocrotaline rats treated with vehicle, and monocrotaline rats treated with SC-144.

Sample Preparation:

Sampleprep ID:SP001953
Sampleprep Summary:Frozen right ventricles

Chromatography:

Chromatography ID:CH002245
Chromatography Summary:Low pH polar
Instrument Name:Waters Acquity
Column Name:Waters Acquity BEH C18 (100 x 2mm,1.7um)
Chromatography Type:Reversed phase

Analysis:

Analysis ID:AN003032
Analysis Type:MS
Chromatography ID:CH002245
Num Factors:3
Num Metabolites:767
Rt Units:Seconds
Units:relative value
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