Summary of Study ST003791

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002367. The data can be accessed directly via it's Project DOI: 10.21228/M8P55Q This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003791
Study TitleAssociations between lipoprotein subclasses and cardiovascular health in ageing
Study SummaryAbnormal lipoprotein profiles have been frequently described in association with atherogenic cardiovascular diseases. The relevance of lipoproteins in human cardiovascular health with ageing, which commonly manifests as heart failure in older adults, is less often investigated. Capitalizing on 1H NMR spectroscopy which identifies lipoprotein subclasses with great detail, we explored in-depth associations between 112 lipoproteins and cardiac function of N=474 unique older adults, hypothesizing that specific lipoproteins may be associated with cardiac ageing.Decreases in intermediate density LDLs (1.034-1.037 g/mL) and increases in intermediate density VLDLs (0.961-0.995 g/mL) were observed among older adults with poorer cardiac function. There was heterogeneous distribution of low density (0.950-0.961 g/mL) VLDL fractions, which became more prominent in patients with poor cardiac function. Prominent apolipoprotein-A increases specific to those with poorer cardiac function were observed among those taking lipid lowering medications, localized to specific lower density HDL fractions (1.063-1.112 g/mL).
Institute
Nanyang Technological University
DepartmentLee Kong Chian School of Medicine
LaboratorySingapore Phenome Centre
Last NameYu King Hing
First NameNathaphon
Address59 Nanyang Drive
Emailjoel.yukh@ntu.edu.sg
Phone83199405
Submit Date2025-03-09
Total Subjects474
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2025-03-14
Release Version1
Nathaphon Yu King Hing Nathaphon Yu King Hing
https://dx.doi.org/10.21228/M8P55Q
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR002367
Project DOI:doi: 10.21228/M8P55Q
Project Title:Associations between lipoprotein subclasses and cardiovascular health in ageing
Project Summary:Abnormal lipoprotein profiles have been frequently described in association with atherogenic cardiovascular diseases. The relevance of lipoproteins in human cardiovascular health with ageing, which commonly manifests as heart failure in older adults, is less often investigated. Capitalizing on 1H NMR spectroscopy which identifies lipoprotein subclasses with great detail, we explored in-depth associations between 112 lipoproteins and cardiac function of N=474 unique older adults, hypothesizing that specific lipoproteins may be associated with cardiac ageing.Decreases in intermediate density LDLs (1.034-1.037 g/mL) and increases in intermediate density VLDLs (0.961-0.995 g/mL) were observed among older adults with poorer cardiac function. There was heterogeneous distribution of low density (0.950-0.961 g/mL) VLDL fractions, which became more prominent in patients with poor cardiac function. Prominent apolipoprotein-A increases specific to those with poorer cardiac function were observed among those taking lipid lowering medications, localized to specific lower density HDL fractions (1.063-1.112 g/mL).
Institute:Nanyang Technological University
Department:Lee Kong Chian School of Medicine
Laboratory:Singapore Phenome Centre
Last Name:Yu King Hing
First Name:Nathaphon
Address:59 Nanyang Drive Singapore
Email:joel.yukh@ntu.edu.sg
Phone:83199405

Subject:

Subject ID:SU003925
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Age Or Age Range:21-84
Gender:Male and female

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source E/A < 0.8 Hypertension Dyslipidemia Diabetes mellitus Hypertension_Med Cholesterol_Med Diabetes_Med Sex
SA412547170Blood 0 0 0 0 0 0 0 F
SA412548146Blood 0 0 0 0 0 0 0 F
SA412549147Blood 0 0 0 0 0 0 0 F
SA412550149Blood 0 0 0 0 0 0 0 F
SA412551150Blood 0 0 0 0 0 0 0 F
SA412552152Blood 0 0 0 0 0 0 0 F
SA412553154Blood 0 0 0 0 0 0 0 F
SA412554155Blood 0 0 0 0 0 0 0 F
SA412555164Blood 0 0 0 0 0 0 0 F
SA412556166Blood 0 0 0 0 0 0 0 F
SA412557174Blood 0 0 0 0 0 0 0 F
SA412558144Blood 0 0 0 0 0 0 0 F
SA412559175Blood 0 0 0 0 0 0 0 F
SA412560176Blood 0 0 0 0 0 0 0 F
SA412561177Blood 0 0 0 0 0 0 0 F
SA412562179Blood 0 0 0 0 0 0 0 F
SA412563180Blood 0 0 0 0 0 0 0 F
SA412564189Blood 0 0 0 0 0 0 0 F
SA412565190Blood 0 0 0 0 0 0 0 F
SA412566191Blood 0 0 0 0 0 0 0 F
SA412567193Blood 0 0 0 0 0 0 0 F
SA412568145Blood 0 0 0 0 0 0 0 F
SA412569143Blood 0 0 0 0 0 0 0 F
SA412570199Blood 0 0 0 0 0 0 0 F
SA412571120Blood 0 0 0 0 0 0 0 F
SA412572103Blood 0 0 0 0 0 0 0 F
SA412573105Blood 0 0 0 0 0 0 0 F
SA412574107Blood 0 0 0 0 0 0 0 F
SA412575108Blood 0 0 0 0 0 0 0 F
SA412576109Blood 0 0 0 0 0 0 0 F
SA412577110Blood 0 0 0 0 0 0 0 F
SA412578115Blood 0 0 0 0 0 0 0 F
SA412579116Blood 0 0 0 0 0 0 0 F
SA412580118Blood 0 0 0 0 0 0 0 F
SA412581122Blood 0 0 0 0 0 0 0 F
SA412582141Blood 0 0 0 0 0 0 0 F
SA412583123Blood 0 0 0 0 0 0 0 F
SA412584124Blood 0 0 0 0 0 0 0 F
SA412585129Blood 0 0 0 0 0 0 0 F
SA412586131Blood 0 0 0 0 0 0 0 F
SA412587132Blood 0 0 0 0 0 0 0 F
SA412588133Blood 0 0 0 0 0 0 0 F
SA412589135Blood 0 0 0 0 0 0 0 F
SA412590136Blood 0 0 0 0 0 0 0 F
SA412591137Blood 0 0 0 0 0 0 0 F
SA412592197Blood 0 0 0 0 0 0 0 F
SA412593200Blood 0 0 0 0 0 0 0 F
SA41259499Blood 0 0 0 0 0 0 0 F
SA412595380Blood 0 0 0 0 0 0 0 F
SA412596283Blood 0 0 0 0 0 0 0 F
SA412597301Blood 0 0 0 0 0 0 0 F
SA412598316Blood 0 0 0 0 0 0 0 F
SA412599334Blood 0 0 0 0 0 0 0 F
SA412600339Blood 0 0 0 0 0 0 0 F
SA412601340Blood 0 0 0 0 0 0 0 F
SA412602341Blood 0 0 0 0 0 0 0 F
SA412603347Blood 0 0 0 0 0 0 0 F
SA412604379Blood 0 0 0 0 0 0 0 F
SA412605411Blood 0 0 0 0 0 0 0 F
SA412606262Blood 0 0 0 0 0 0 0 F
SA412607412Blood 0 0 0 0 0 0 0 F
SA412608417Blood 0 0 0 0 0 0 0 F
SA412609419Blood 0 0 0 0 0 0 0 F
SA412610441Blood 0 0 0 0 0 0 0 F
SA412611446Blood 0 0 0 0 0 0 0 F
SA412612452Blood 0 0 0 0 0 0 0 F
SA412613455Blood 0 0 0 0 0 0 0 F
SA412614463Blood 0 0 0 0 0 0 0 F
SA412615465Blood 0 0 0 0 0 0 0 F
SA412616273Blood 0 0 0 0 0 0 0 F
SA412617260Blood 0 0 0 0 0 0 0 F
SA412618202Blood 0 0 0 0 0 0 0 F
SA412619225Blood 0 0 0 0 0 0 0 F
SA412620206Blood 0 0 0 0 0 0 0 F
SA412621208Blood 0 0 0 0 0 0 0 F
SA412622209Blood 0 0 0 0 0 0 0 F
SA412623211Blood 0 0 0 0 0 0 0 F
SA412624216Blood 0 0 0 0 0 0 0 F
SA412625220Blood 0 0 0 0 0 0 0 F
SA412626222Blood 0 0 0 0 0 0 0 F
SA412627223Blood 0 0 0 0 0 0 0 F
SA412628224Blood 0 0 0 0 0 0 0 F
SA412629226Blood 0 0 0 0 0 0 0 F
SA412630259Blood 0 0 0 0 0 0 0 F
SA412631229Blood 0 0 0 0 0 0 0 F
SA412632234Blood 0 0 0 0 0 0 0 F
SA412633236Blood 0 0 0 0 0 0 0 F
SA412634239Blood 0 0 0 0 0 0 0 F
SA412635242Blood 0 0 0 0 0 0 0 F
SA412636243Blood 0 0 0 0 0 0 0 F
SA412637244Blood 0 0 0 0 0 0 0 F
SA412638245Blood 0 0 0 0 0 0 0 F
SA412639248Blood 0 0 0 0 0 0 0 F
SA412640250Blood 0 0 0 0 0 0 0 F
SA412641101Blood 0 0 0 0 0 0 0 F
SA4126421Blood 0 0 0 0 0 0 0 F
SA41264398Blood 0 0 0 0 0 0 0 F
SA41264456Blood 0 0 0 0 0 0 0 F
SA41264530Blood 0 0 0 0 0 0 0 F
SA41264653Blood 0 0 0 0 0 0 0 F
Showing page 1 of 5     Results:    1  2  3  4  5  Next     Showing results 1 to 100 of 474

Collection:

Collection ID:CO003918
Collection Summary:The subjects were recruited from the Cardiac Ageing Study (CAS) 34, a prospective study initiated in 2014 examining the characteristics and determinants of cardiac structural and functional changes with aging. CAS participants were recruited from the prospective, population-based cohort, the Singapore Chinese Health Study (SCHS) 35, and directly from the local community. The current study sample consisted of community-dwelling men and women who participated in the baseline CAS 2014–2017 examination with no self-reported history of physician-diagnosed cardiovascular disease (such as coronary heart disease, atrial fibrillation), stroke, or cancer. Written informed consent was obtained from participants upon enrolment. The SingHealth Centralised Institutional Review Board (CIRC/2014/628/C) approved the study protocol.
Sample Type:Blood (serum)
Storage Conditions:-80℃

Treatment:

Treatment ID:TR003934
Treatment Summary:Samples were not treated. Factors (0 = negative, 1 = positive): If E/A < 0.8 = 1, the subject’s echocardiographic E/A ratio is below 0.8. The E/A is defined as the ratio of peak velocity blood flow from left ventricular relaxation in early diastole (the E wave) to peak velocity flow in late diastole caused by atrial contraction (the A wave). If Hypertension, Dyslipidemia, or Diabetes mellitus = 1, the subject has been positively diagnosed with the factor. If Hypertension_Med, Cholesterol_Med, or Diabetes_Med = 1, the subject actively takes anti-hypertensives, cholesterol reducing medicine(s), or anti-diabetics.

Sample Preparation:

Sampleprep ID:SP003931
Sampleprep Summary:350 μL of each blood serum sample were mixed with 350 μL of phosphate buffer for plasma (Bruker Biospin, Germany, pH 7.4) into a 5 mm diameter NMR tube using an automated liquid handler (Burker SamplePro Tube). NMR tubes were kept in SampleJet (Bruker Biospin, Germany) at 4 oC and NMR experiment were performed automatically on 600 MHz AVANCE III NMR spectrometer equipped with BBI probe (Bruker Biospin, Germany).
Processing Storage Conditions:-80℃

Analysis:

Analysis ID:AN006232
Laboratory Name:Singapore Phenome Centre
Analysis Type:NMR
Num Factors:46
Num Metabolites:112
Units:mg/dL

NMR:

NMR ID:NM000311
Analysis ID:AN006232
Instrument Name:Bruker 600 MHz AVANCE III
Instrument Type:FT-NMR
NMR Experiment Type:1D-1H
Spectrometer Frequency:600 MHz
Temperature:4
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