Summary of Study ST004139

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002604. The data can be accessed directly via it's Project DOI: 10.21228/M8284S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST004139
Study TitleMetabolic Profiling of Saliva for Determination of Pathogenesis, Diagnosis, and Prognosis in Gestational Diabetes Mellitus in the First and Second Trimester
Study TypeProspective Nested Case–Control Clinical Cohort Study
Study SummaryIn the study we comprehensively describe the metabolic characteristics of GDM based on metabolomics of second-trimester biofluid samples, including saliva, serum, and urine, and explore the potential for exploration of pathogenesis, early diagnosis, and prognosis prediction.
Institute
Zhejiang University
DepartmentObstetrical Department, Women's Hospital, School of Medicine, Life Sciences Division
LaboratoryZhejiang Key Laboratory of Maternal and Infant Health
Last NameQi
First NameWu
AddressNo. 1, Xueshi Road, Shangcheng District, Hangzhou, Zhejiang Province, China
Email428102@zju.edu.cn
Phone+86-13588412286
Submit Date2025-08-14
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailMALDI-MS
Release Date2025-10-08
Release Version1
Wu Qi Wu Qi
https://dx.doi.org/10.21228/M8284S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR002604
Project DOI:doi: 10.21228/M8284S
Project Title:Metabolic Profiling of Saliva for Determination of Pathogenesis, Diagnosis, and Prognosis in Gestational Diabetes Mellitus in the First and Second Trimester
Project Type:Prospective Nested Case–Control Cilnical Cohort Study
Project Summary:In the study we comprehensively describe the metabolic characteristics of GDM based on metabolomics of second-trimester biofluid samples, including saliva, serum, and urine(this section only includes saliva), and explore the potential for exploration of pathogenesis, early diagnosis, and prognosis prediction.
Institute: Zhejiang University
Department:Obstetrical Department, Women's Hospital, School of Medicine, Life Sciences Division
Laboratory:Zhejiang Key Laboratory of Maternal and Infant Health, Hangzhou, China
Last Name:Qi
First Name:Wu
Address:No. 1, Xueshi Road, Shangcheng District, Hangzhou, Zhejiang Province, China, Hangzhou, Zhejiang/Hangzhou, 310009, China
Email:428102@zju.edu.cn
Phone:+86-13588412286

Subject:

Subject ID:SU004289
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Female

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Group Sample source
SA477096E4YCGDM Saliva
SA477097E4YQGDM Saliva
SA477098E4YPGDM Saliva
SA477099E4YNGDM Saliva
SA477100E4YMGDM Saliva
SA477101E4YLGDM Saliva
SA477102E4YJGDM Saliva
SA477103E4YHGDM Saliva
SA477104E4YGGDM Saliva
SA477105E4YFGDM Saliva
SA477106E4YEGDM Saliva
SA477107E4YBGDM Saliva
SA477108E4YSGDM Saliva
SA477109E4YAGDM Saliva
SA477110E4Y9GDM Saliva
SA477111E4Y8GDM Saliva
SA477112E4Y7GDM Saliva
SA477113E4Y5GDM Saliva
SA477114E4Y4GDM Saliva
SA477115E4Y3GDM Saliva
SA477116E4Y2GDM Saliva
SA477117E4Y1GDM Saliva
SA477118E4Y0GDM Saliva
SA477119E4YRGDM Saliva
SA477120E4YTGDM Saliva
SA477121E4XYGDM Saliva
SA477122E4VY_2GDM Saliva
SA477123Q0DLGDM Saliva
SA477124Q0DQGDM Saliva
SA477125Q0DXGDM Saliva
SA477126Q0E1GDM Saliva
SA477127E4WQ_2GDM Saliva
SA477128E4WN_2GDM Saliva
SA477129E4WF_2GDM Saliva
SA477130E4WE_2GDM Saliva
SA477131E4W1_2GDM Saliva
SA477132E4VZ_2GDM Saliva
SA477133Q0E3GDM Saliva
SA477134E4YUGDM Saliva
SA477135E4VQ_2GDM Saliva
SA477136E4VN_2GDM Saliva
SA477137E4VM_2GDM Saliva
SA477138E4VHGDM Saliva
SA477139E4VG_2GDM Saliva
SA477140Q0E4GDM Saliva
SA477141Q0E6GDM Saliva
SA477142Q0EAGDM Saliva
SA477143E4QA_2GDM Saliva
SA477144E4YWGDM Saliva
SA477145E4XZGDM Saliva
SA477146E4XXGDM Saliva
SA477147Q0DAGDM Saliva
SA477148E4W3GDM Saliva
SA477149E4WHGDM Saliva
SA477150E4WFGDM Saliva
SA477151E4WEGDM Saliva
SA477152E4WCGDM Saliva
SA477153E4WBGDM Saliva
SA477154E4W9GDM Saliva
SA477155E4W8GDM Saliva
SA477156E4W6GDM Saliva
SA477157E4W5GDM Saliva
SA477158E4W4GDM Saliva
SA477159E4W2GDM Saliva
SA477160E4WLGDM Saliva
SA477161E4W1GDM Saliva
SA477162E4W0GDM Saliva
SA477163E4VZGDM Saliva
SA477164E4VYGDM Saliva
SA477165E4VXGDM Saliva
SA477166E4VWGDM Saliva
SA477167E4VTGDM Saliva
SA477168E4VSGDM Saliva
SA477169E4VRGDM Saliva
SA477170E4VQGDM Saliva
SA477171E4WKGDM Saliva
SA477172E4WMGDM Saliva
SA477173E4XWGDM Saliva
SA477174E4XFGDM Saliva
SA477175E4XUGDM Saliva
SA477176E4XTGDM Saliva
SA477177E4XSGDM Saliva
SA477178E4XRGDM Saliva
SA477179E4XPGDM Saliva
SA477180E4XMGDM Saliva
SA477181E4XLGDM Saliva
SA477182E4XKGDM Saliva
SA477183E4XJGDM Saliva
SA477184E4XHGDM Saliva
SA477185E4XEGDM Saliva
SA477186E4WNGDM Saliva
SA477187E4XDGDM Saliva
SA477188E4XCGDM Saliva
SA477189E4X2GDM Saliva
SA477190E4X1GDM Saliva
SA477191E4WVGDM Saliva
SA477192E4WUGDM Saliva
SA477193E4WTGDM Saliva
SA477194E4WSGDM Saliva
SA477195E4WQGDM Saliva
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Collection:

Collection ID:CO004282
Collection Summary:Biofluid samples were collected on the same day as the OGTT during GW 24–28. Saliva was collected as previously described.1 Briefly, saliva was collected using a specific device and the passive drooling method after an overnight fast. Saliva mixed with gingival bleeding or other conditions were excluded (normal samples should be transparent and clear). All biofluid samples were pretreated and stored at −80°C until analysis.
Collection Protocol ID:SOP-GDM-COL-20250501
Collection Protocol Filename:Saliva_Metabolites_Samplecollection_V1.1.pdf
Sample Type:Saliva
Storage Conditions:-80℃
Collection Vials:2 mL polypropylene cryovials (Sarstedt) for all biofluids.
Storage Vials:Same as collection vials (2 mL cryovials).
Collection Tube Temp:Room temperature (20–25 °C) during collection.

Treatment:

Treatment ID:TR004298
Treatment Summary:Briefly, saliva was collected using a specific device and the passive drooling method after an overnight fast,All biofluid samples were pretreated and stored at −80°C until analysis.

Sample Preparation:

Sampleprep ID:SP004295
Sampleprep Summary:An aliquot of 40 μL of acetonitrile/methanol (1:1) solution was first added to 20 μL of saliva sample thawing on ice, and the mixture was shaken at 1,500 rpm for 5 min and centrifuged at 8,045 × g for 10 min. The supernatant was transferred to a fresh centrifuge tube, and 5 μL of ultrapure water was added. Then, 0.8 μL of the mixture was deposited onto the Met-Si Array® chip (WELL Healthcare Technologies) containing arrays of vertical silicon nanowire structures (2,830, 342, 364) for detection.
Sampleprep Protocol ID:SOP-GDM-EXT-20250501
Sampleprep Protocol Filename:Saliva_Metabolite_Extraction_SOP_V1.1
Processing Method:In vitro mixing and centrifugation; liquid–liquid extraction; on-chip adsorption
Processing Storage Conditions:On ice
Extraction Method:Saliva: 40 µL ACN/MeOH (1:1) added to 20 µL sample; All steps at 4 °C; exclusion of visibly hemolyzed or turbid samples. Sample metabolite extraction Acetonitrile/Methanol (1:1), Methyl tert-butyl ether, IPA/H₂O (1:1)
Extract Storage:4℃

Chromatography:

Chromatography ID:CH005216
Chromatography Summary:After processing, the sample is directly spotted onto a specially treated chip, fixed onto the target plate for MALDI‑TOF detection, without the use of a chromatography column.
Instrument Name:none
Column Name:none
Column Temperature:none
Flow Gradient:none
Flow Rate:none
Solvent A:none
Solvent B:none
Chromatography Type:None (Direct infusion)

Analysis:

Analysis ID:AN006862
Analysis Type:MS
Chromatography ID:CH005216
Has Mz:1
Rt Units:No RT data
Results File:ST004139_AN006862_Results.txt
Units:Intensity (baseline corrected)
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