ST002085 A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy(Part 1)
Limit by pathway class:
   Minimum # of metabolites per pathway:

Pathway name (# of metabolites detected in this study)HMDB pathwayKEGG pathway
Alanine Metabolism (5) SMP0000055 map00250
Amino Sugar Metabolism (3) SMP0000045 map00520
Ammonia Recycling (6) SMP0000009 map00910
Arachidonic Acid Metabolism (2) SMP0000075 map00590
Arginine and Proline Metabolism (12) SMP0000020 map00330
Aspartate Metabolism (9) SMP0000067 map00250
beta-Alanine Metabolism (5) SMP0000007 map00410
Betaine Metabolism (2) SMP0000123 map00260
Bile Acid Biosynthesis (1) SMP0000035 map00120
Biotin Metabolism (1) SMP0000066 map00780
Butyrate Metabolism (1) SMP0000073 map00650
Carnitine Synthesis (3) SMP0000465 -
Citric Acid Cycle (6) SMP0000057 map00020
Cysteine Metabolism (4) SMP0000013 map00270
Folate Metabolism (1) SMP0000053 map00670
Gluconeogenesis (5) SMP0000128 map00010
Glucose-Alanine Cycle (3) SMP0000127 -
Glutamate Metabolism (9) SMP0000072 map00250
Glutathione Metabolism (3) SMP0000015 map00480
Glycine and Serine Metabolism (9) SMP0000004 map00260
Glycolysis (1) SMP0000040 map00010
Histidine Metabolism (3) SMP0000044 map00340
Homocysteine Degradation (2) SMP0000455 -
Ketone Body Metabolism (1) SMP0000071 map00072
Lysine Degradation (3) SMP0000037 map00310
Malate-Aspartate Shuttle (5) SMP0000129 -
Methionine Metabolism (5) SMP0000033 map00270
Methylhistidine Metabolism (1) SMP0000715 -
Mitochondrial Electron Transport Chain (2) SMP0000355 map00190
Nicotinate and Nicotinamide Metabolism (2) SMP0000048 map00760
Oxidation of Branched Chain Fatty Acids (2) SMP0000030 -
Oxidation of Branched-Chain Fatty Acids (2) SMP0000030 -
Pantothenate and CoA Biosynthesis (1) SMP0000027 map00770
Phenylacetate Metabolism (1) SMP0000126 map00360
Phenylalanine and Tyrosine Metabolism (4) SMP0000008 map00360
Phosphatidylcholine Biosynthesis (1) SMP0014212 -
Phosphatidylethanolamine Biosynthesis (1) SMP0029731 -
Phospholipid Biosynthesis (1) SMP0000025 map00564
Phytanic Acid Peroxisomal Oxidation (2) SMP0000450 -
Propanoate Metabolism (3) SMP0000016 map00640
Purine Metabolism (5) SMP0000050 map00230
Pyrimidine Metabolism (1) SMP0000046 map00240
Pyruvaldehyde Degradation (2) SMP0000459 -
Pyruvate Metabolism (5) SMP0000060 map00620
Spermidine and Spermine Biosynthesis (4) SMP0000445 -
Sphingolipid Metabolism (1) SMP0000034 map00600
Taurine and Hypotaurine Metabolism (2) SMP0000021 map00430
Threonine and 2-Oxobutanoate Degradation (1) SMP0000452 -
Transfer of Acetyl Groups into Mitochondria (3) SMP0000466 -
Tryptophan Metabolism (3) SMP0000063 map00380
Tyrosine Metabolism (5) SMP0000006 map00350
Urea Cycle (11) SMP0000059 map00330
Valine, Leucine and Isoleucine Degradation (5) SMP0000032 map00280
Warburg Effect (9) SMP0000654 -
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