ST000001 Fatb Induction Experiment (FatBIE)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (2) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (3) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (3) REACT_17003
Amino acid synthesis and interconversion (transamination) (9) REACT_238
Amino acid transport across the plasma membrane (18) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (17) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (5) REACT_197
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (17) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (18) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (3) REACT_23964
Digestion of dietary carbohydrate (3) REACT_9472
Digestion of dietary lipid (1) REACT_9518
Endosomal/Vacuolar pathway (17) REACT_111168
eNOS activation (3) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (17) REACT_111178
Ethanol oxidation (1) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
Free fatty acid receptors (3) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (6) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (18) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycolysis (3) REACT_1383
Glyoxylate metabolism (4) REACT_16925
HDMs demethylate histones (2) REACT_228178
Heme biosynthesis (1) REACT_9465
Histidine catabolism (1) REACT_1249
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (2) REACT_14805
ISG15 antiviral mechanism (1) REACT_115831
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (3) REACT_14820
Methionine salvage pathway (1) REACT_75881
Methylation (2) REACT_6946
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (18) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (16) REACT_20506
NADPH regeneration (1) REACT_16904
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
Plasmalogen biosynthesis (1) REACT_1407
PPARA activates gene expression (2) REACT_116145
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (17) REACT_19328
Purine catabolism (2) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (2) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Respiratory electron transport (1) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
RORA activates circadian gene expression (2) REACT_118659
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (4) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (3) REACT_21330
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (3) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (2) REACT_15292
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (5) REACT_23892
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (5) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (6) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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