ST000020 Biomarker Discovery in Knee Osteoarthritis (I)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (2) REACT_121117
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (1) REACT_228214
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid transport across the plasma membrane (5) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (3) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (3) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biotin transport and metabolism (1) REACT_11153
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Citric acid cycle (TCA cycle) (1) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (1) REACT_18319
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Creatine metabolism (2) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (3) REACT_111056
Cytosolic tRNA aminoacylation (3) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (1) REACT_23964
Endosomal/Vacuolar pathway (3) REACT_111168
ER-Phagosome pathway (3) REACT_111178
Ethanol oxidation (1) REACT_34
FMO oxidises nucleophiles (2) REACT_13653
Free fatty acid receptors (1) REACT_21268
G alpha (i) signalling events (2) REACT_19231
G alpha (q) signalling events (2) REACT_18283
Glutathione synthesis and recycling (3) REACT_6960
Glyoxylate metabolism (1) REACT_16925
HDMs demethylate histones (1) REACT_228178
HS-GAG biosynthesis (1) REACT_121248
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Lysine catabolism (1) REACT_1298
Mitochondrial tRNA aminoacylation (3) REACT_15302
Na+/Cl- dependent neurotransmitter transporters (5) REACT_20506
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (1) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (1) REACT_22357
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
Phenylalanine and tyrosine catabolism (2) REACT_1786
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton/oligonucleotide cotransporters (3) REACT_19328
Pyruvate metabolism (1) REACT_2071
Recycling of bile acids and salts (1) REACT_11042
Reuptake of GABA (1) REACT_23910
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sulfur amino acid metabolism (2) REACT_115639
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The fatty acid cycling model (1) REACT_6258
Thyroxine biosynthesis (1) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Tryptophan catabolism (1) REACT_916
Utilization of Ketone Bodies (1) REACT_59
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