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ST000025 Metabolomics Analysis of Thermally Challenged Mayfly Larvae (GCMS analysis)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1)
REACT_850
Abacavir metabolism (3)
REACT_121388
ABCA transporters in lipid homeostasis (1)
REACT_111158
Abnormal metabolism in phenylketonuria (2)
REACT_121117
Activation of gene expression by SREBF (SREBP) (2)
REACT_147904
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
alpha-linolenic acid (ALA) metabolism (1)
REACT_121147
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (11)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (10)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Biotin transport and metabolism (1)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2)
REACT_111118
Branched-chain amino acid catabolism (3)
REACT_197
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (1)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Cell surface interactions at the vascular wall (1)
REACT_12051
Cholesterol biosynthesis (1)
REACT_9405
Chylomicron-mediated lipid transport (1)
REACT_6841
Circadian Clock (2)
REACT_24941
Citric acid cycle (TCA cycle) (3)
REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (1)
REACT_18319
Coenzyme A biosynthesis (1)
REACT_11218
Conjugation of benzoate with glycine (3)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (3)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (9)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (10)
REACT_15306
DARPP-32 events (1)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Degradation of cysteine and homocysteine (1)
REACT_115654
Digestion of dietary carbohydrate (1)
REACT_9472
Digestion of dietary lipid (1)
REACT_9518
Endogenous sterols (1)
REACT_13812
Endosomal/Vacuolar pathway (9)
REACT_111168
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (9)
REACT_111178
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acids (2)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2)
REACT_19193
Fatty Acyl-CoA Biosynthesis (2)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
Free fatty acid receptors (4)
REACT_21268
G alpha (i) signalling events (2)
REACT_19231
G alpha (q) signalling events (3)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
Gluconeogenesis (3)
REACT_1520
Glutathione synthesis and recycling (10)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycolysis (2)
REACT_1383
Glyoxylate metabolism (3)
REACT_16925
HDL-mediated lipid transport (1)
REACT_13621
Hedgehog ligand biogenesis (1)
REACT_228111
Heme biosynthesis (1)
REACT_9465
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1)
REACT_494
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Inositol transporters (1)
REACT_19188
Interconversion of polyamines (2)
REACT_14805
ISG15 antiviral mechanism (1)
REACT_115831
LDL-mediated lipid transport (1)
REACT_6934
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (2)
REACT_121100
Metabolism of folate and pterines (2)
REACT_11167
Metabolism of polyamines (3)
REACT_14820
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (10)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (9)
REACT_20506
NGF-independant TRKA activation (1)
REACT_11046
Nicotinate metabolism (1)
REACT_11088
Organic anion transport (1)
REACT_22310
Organic anion transporters (2)
REACT_19372
Organic cation transport (1)
REACT_22357
Orphan transporters (3)
REACT_267716
PAOs oxidise polyamines to amines (2)
REACT_505
Passive transport by Aquaporins (1)
REACT_23826
PDE3B signalling (1)
REACT_1451
Phenylalanine and tyrosine catabolism (2)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
phospho-PLA2 pathway (1)
REACT_15466
Platelet sensitization by LDL (1)
REACT_23879
PPARA activates gene expression (2)
REACT_116145
Pregnenolone biosynthesis (1)
REACT_11038
Proton-coupled monocarboxylate transport (1)
REACT_20515
Proton-coupled neutral amino acid transporters (2)
REACT_19348
Proton/oligonucleotide cotransporters (9)
REACT_19328
Purine catabolism (4)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2)
REACT_1776
Purine salvage (4)
REACT_1923
Pyrimidine catabolism (2)
REACT_1023
Pyrimidine salvage reactions (1)
REACT_655
Pyruvate metabolism (1)
REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Recycling of bile acids and salts (2)
REACT_11042
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1)
REACT_147797
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2)
REACT_19241
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (1)
REACT_70
Removal of the Flap Intermediate from the C-strand (1)
REACT_7999
Respiratory electron transport (1)
REACT_22393
Retinoid metabolism and transport (3)
REACT_24968
REV-ERBA represses gene expression (2)
REACT_118789
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (2)
REACT_118659
Scavenging by Class A Receptors (1)
REACT_163699
Scavenging by Class B Receptors (1)
REACT_163679
Scavenging by Class F Receptors (1)
REACT_163813
Scavenging by Class H Receptors (1)
REACT_164002
Scavenging of heme from plasma (1)
REACT_160163
Serine biosynthesis (1)
REACT_115789
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (1)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (2)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (1)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts (1)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3)
REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PE (1)
REACT_120919
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (4)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2)
REACT_23824
The canonical retinoid cycle in rods (twilight vision) (2)
REACT_160156
Thyroxine biosynthesis (2)
REACT_15292
Trafficking of dietary sterols (1)
REACT_13781
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (4)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (4)
REACT_1206
Tryptophan catabolism (1)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (3)
REACT_847
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (1)
REACT_11070
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2)
REACT_118713
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