ST000040 Heatshock response of C. elegans using IROA (I)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2) REACT_850
Abacavir metabolism (3) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylation (1) REACT_6732
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (2) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (3) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (3) REACT_17003
Amino acid synthesis and interconversion (transamination) (10) REACT_238
Amino acid transport across the plasma membrane (16) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (15) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (16) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (3) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (5) REACT_197
Ca2+ pathway (2) REACT_172761
Cam-PDE 1 activation (2) REACT_15408
Carnitine synthesis (4) REACT_2125
Catecholamine biosynthesis (3) REACT_15551
cGMP effects (2) REACT_23767
Cholesterol biosynthesis (3) REACT_9405
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (5) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (7) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (2) REACT_1729
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (3) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COX reactions (1) REACT_1396
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (15) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (16) REACT_15306
DARPP-32 events (2) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (5) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary carbohydrate (1) REACT_9472
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (15) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (15) REACT_111178
Ethanol oxidation (1) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (1) REACT_21268
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (3) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (9) REACT_19231
G alpha (q) signalling events (6) REACT_18283
G alpha (s) signalling events (4) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Gluconeogenesis (8) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (17) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (3) REACT_1383
Glyoxylate metabolism (1) REACT_16925
HCN channels (1) REACT_75862
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (5) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (2) REACT_14805
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (2) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (5) REACT_1298
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (3) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (4) REACT_75881
Methylation (4) REACT_6946
Miscellaneous substrates (2) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (16) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (15) REACT_20506
NADPH regeneration (1) REACT_16904
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
NOSIP mediated eNOS trafficking (1) REACT_12510
NOSTRIN mediated eNOS trafficking (1) REACT_12541
Organic anion transport (2) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (3) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
PDE3B signalling (2) REACT_1451
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (6) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
phospho-PLA2 pathway (1) REACT_15466
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
PPARA activates gene expression (1) REACT_116145
PRC2 methylates histones and DNA (1) REACT_200808
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (15) REACT_19328
Purine catabolism (13) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (11) REACT_1923
Pyrimidine biosynthesis (8) REACT_21376
Pyrimidine catabolism (11) REACT_1023
Pyrimidine salvage reactions (8) REACT_655
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation by TREX1 (3) REACT_163652
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of ornithine decarboxylase (ODC) (1) REACT_13565
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (4) REACT_70
Removal of the Flap Intermediate from the C-strand (4) REACT_7999
Respiratory electron transport (2) REACT_22393
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (1) REACT_118789
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serine biosynthesis (3) REACT_115789
Serotonin and melatonin biosynthesis (4) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Stimuli-sensing channels (2) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (5) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (10) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of PC (2) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (3) REACT_111176
Thyroxine biosynthesis (2) REACT_15292
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (11) REACT_1206
Transport of nucleotide sugars (3) REACT_22151
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (3) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (7) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFR2 mediated vascular permeability (3) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (3) REACT_11070
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (4) REACT_25012
Xenobiotics (1) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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