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ST000051 Fetal metabolomic signature of exposure to iAs during pregnancyList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (1)
REACT_1662
Abnormal metabolism in phenylketonuria (3)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Acyl chain remodeling of DAG and TAG (2)
REACT_121122
Aflatoxin activation and detoxification (3)
REACT_228214
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (9)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9)
REACT_75842
Arachidonate production from DAG (2)
REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (4)
REACT_197
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Citric acid cycle (TCA cycle) (2)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (2)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2)
REACT_18319
Collagen biosynthesis and modifying enzymes (1)
REACT_121139
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (3)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (9)
REACT_111056
CYP2E1 reactions (1)
REACT_13797
Cytosolic tRNA aminoacylation (9)
REACT_15306
Degradation of GABA (2)
REACT_23964
Digestion of dietary lipid (1)
REACT_9518
Endosomal/Vacuolar pathway (9)
REACT_111168
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (9)
REACT_111178
Ethanol oxidation (2)
REACT_34
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
FMO oxidises nucleophiles (1)
REACT_13653
Free fatty acid receptors (1)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (5)
REACT_19231
G alpha (q) signalling events (4)
REACT_18283
Gluconeogenesis (3)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (9)
REACT_6960
Glycolysis (2)
REACT_1383
Glyoxylate metabolism (3)
REACT_16925
HDMs demethylate histones (1)
REACT_228178
Heme biosynthesis (1)
REACT_9465
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histidine catabolism (1)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1)
REACT_494
HS-GAG biosynthesis (1)
REACT_121248
Hydrolysis of LPC (1)
REACT_120977
Hydroxycarboxylic acid-binding receptors (2)
REACT_163785
Ligand-gated ion channel transport (1)
REACT_25387
Lysine catabolism (2)
REACT_1298
Metabolism of folate and pterines (2)
REACT_11167
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (9)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (8)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
Nicotinate metabolism (2)
REACT_11088
NoRC negatively regulates rRNA expression (1)
REACT_200856
Organic anion transport (1)
REACT_22310
Organic anion transporters (4)
REACT_19372
Organic cation transport (2)
REACT_22357
Oxidative Stress Induced Senescence (1)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_120916
Passive transport by Aquaporins (1)
REACT_23826
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (1)
REACT_1002
Proton-coupled monocarboxylate transport (3)
REACT_20515
Proton-coupled neutral amino acid transporters (2)
REACT_19348
Proton/oligonucleotide cotransporters (9)
REACT_19328
Purine ribonucleoside monophosphate biosynthesis (3)
REACT_1776
Pyrimidine biosynthesis (2)
REACT_21376
Pyrimidine catabolism (2)
REACT_1023
Pyruvate metabolism (2)
REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Role of phospholipids in phagocytosis (1)
REACT_160158
Serine biosynthesis (1)
REACT_115789
Sialic acid metabolism (1)
REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
Sulfur amino acid metabolism (2)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1)
REACT_952
Synthesis of Ketone Bodies (1)
REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PG (2)
REACT_121280
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis, secretion, and deacylation of Ghrelin (1)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1)
REACT_24019
TET1,2,3 and TDG demethylate DNA (1)
REACT_200682
The fatty acid cycling model (1)
REACT_6258
Thyroxine biosynthesis (2)
REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2)
REACT_19397
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (3)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (1)
REACT_847
Utilization of Ketone Bodies (2)
REACT_59
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