ST000054 Metabolic Microenvironments in Normal Breast and Breast Cancer (MS analysis)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABCA transporters in lipid homeostasis (1) REACT_111158
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (1) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (7) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (8) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (4) REACT_197
Carnitine synthesis (1) REACT_2125
Cell surface interactions at the vascular wall (1) REACT_12051
Cholesterol biosynthesis (1) REACT_9405
Chylomicron-mediated lipid transport (1) REACT_6841
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (1) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (8) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (8) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (3) REACT_23964
Digestion of dietary lipid (3) REACT_9518
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (8) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (8) REACT_111178
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (4) REACT_19193
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
Free fatty acid receptors (6) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (6) REACT_18283
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (9) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (1) REACT_16925
HDL-mediated lipid transport (1) REACT_13621
HDMs demethylate histones (1) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Histidine catabolism (1) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2) REACT_494
HS-GAG degradation (1) REACT_120752
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
LDL-mediated lipid transport (1) REACT_6934
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Mitochondrial tRNA aminoacylation (8) REACT_15302
Na+/Cl- dependent neurotransmitter transporters (6) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinate metabolism (1) REACT_11088
Organic anion transport (1) REACT_22310
Organic anion transporters (2) REACT_19372
Orphan transporters (3) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
Passive transport by Aquaporins (2) REACT_23826
Phenylalanine and tyrosine catabolism (2) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
Platelet sensitization by LDL (1) REACT_23879
PPARA activates gene expression (2) REACT_116145
Pregnenolone biosynthesis (1) REACT_11038
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (8) REACT_19328
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Pyrimidine biosynthesis (2) REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (4) REACT_24968
REV-ERBA represses gene expression (2) REACT_118789
RORA activates circadian gene expression (2) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Scavenging by Class H Receptors (1) REACT_164002
Scavenging of heme from plasma (1) REACT_160163
Serine biosynthesis (3) REACT_115789
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PG (1) REACT_121280
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (4) REACT_23824
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Trafficking of dietary sterols (1) REACT_13781
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (6) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (2) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (3) REACT_847
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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