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ST000091 Quantitative Metabolomics by 1H-NMR and LC-MS/MS Confirms Altered Metabolic Pathways in DiabetesList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abnormal metabolism in phenylketonuria (3)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of G protein gated Potassium channels (1)
REACT_75831
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Aflatoxin activation and detoxification (2)
REACT_228214
Amino acid synthesis and interconversion (transamination) (7)
REACT_238
Amino acid transport across the plasma membrane (18)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (16)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (16)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Branched-chain amino acid catabolism (4)
REACT_197
Carnitine synthesis (1)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Citric acid cycle (TCA cycle) (1)
REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (3)
REACT_18319
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (16)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic tRNA aminoacylation (16)
REACT_15306
Degradation of cysteine and homocysteine (1)
REACT_115654
Degradation of GABA (2)
REACT_23964
Endosomal/Vacuolar pathway (16)
REACT_111168
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (16)
REACT_111178
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
GABA A receptor activation (1)
REACT_24987
GABA A (rho) receptor activation (1)
REACT_25168
GABA B receptor activation (1)
REACT_25031
GABA synthesis (2)
REACT_24020
GABA synthesis, release, reuptake and degradation (1)
REACT_23947
G alpha (i) signalling events (2)
REACT_19231
G alpha (q) signalling events (2)
REACT_18283
Gluconeogenesis (3)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (16)
REACT_6960
Glycolysis (1)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
Heme biosynthesis (1)
REACT_9465
Histidine catabolism (2)
REACT_1249
HS-GAG degradation (1)
REACT_120752
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1)
REACT_25004
Ligand-gated ion channel transport (2)
REACT_25387
Lysine catabolism (1)
REACT_1298
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (1)
REACT_14820
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (16)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (16)
REACT_20506
Nicotinate metabolism (2)
REACT_11088
Organic anion transporters (1)
REACT_19372
Orphan transporters (1)
REACT_267716
Phenylalanine and tyrosine catabolism (3)
REACT_1786
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (16)
REACT_19328
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (2)
REACT_1023
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Reuptake of GABA (2)
REACT_23910
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfur amino acid metabolism (3)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Thyroxine biosynthesis (2)
REACT_15292
Transport of inorganic cations/anions and amino acids/oligopeptides (4)
REACT_19397
Tryptophan catabolism (3)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (3)
REACT_847
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