ST000113 SIRM Analysis of human P493 cells under hypoxia in [U-13C/15N] labeled Glutamine medium (Positive ion mode FTMS)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (19) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (5) REACT_197
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Citric acid cycle (TCA cycle) (5) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic tRNA aminoacylation (19) REACT_15306
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (3) REACT_23964
Endosomal/Vacuolar pathway (19) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (19) REACT_111178
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (4) REACT_18283
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (19) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (2) REACT_228178
Heme biosynthesis (1) REACT_9465
Histidine catabolism (2) REACT_1249
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (1) REACT_14820
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (19) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (17) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transport (2) REACT_22310
Organic anion transporters (3) REACT_19372
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (1) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (19) REACT_19328
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (1) REACT_1023
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Serine biosynthesis (3) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PG (1) REACT_121280
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
Thyroxine biosynthesis (2) REACT_15292
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (5) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin C (ascorbate) metabolism (1) REACT_11202
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