ST000150 Association of Metabolic Profile and Microbiome in Chronic Pressure Ulcer Wounds
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2) REACT_15309
Acetylcholine regulates insulin secretion (2) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (1) REACT_163932
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Aflatoxin activation and detoxification (3) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (8) REACT_238
Amino acid transport across the plasma membrane (17) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (17) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (16) REACT_75842
Arachidonate production from DAG (1) REACT_19308
ARMS-mediated activation (1) REACT_12002
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (5) REACT_197
Ca2+ pathway (1) REACT_172761
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
CDO in myogenesis (1) REACT_21402
Citric acid cycle (TCA cycle) (5) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
Creatine metabolism (6) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
CREB phosphorylation through the activation of Ras (1) REACT_20568
Cross-presentation of soluble exogenous antigens (endosomes) (16) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic tRNA aminoacylation (16) REACT_15306
DAP12 signaling (1) REACT_147814
DCC mediated attractive signaling (1) REACT_22351
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (3) REACT_23964
Downstream signal transduction (1) REACT_17025
DSCAM interactions (1) REACT_25299
EGFR downregulation (1) REACT_12484
EGFR Transactivation by Gastrin (1) REACT_121096
Endosomal/Vacuolar pathway (16) REACT_111168
eNOS activation (1) REACT_12477
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (3) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (16) REACT_111178
Ethanol oxidation (2) REACT_34
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated MAPK activation (1) REACT_163701
FMO oxidises nucleophiles (1) REACT_13653
Formation of the ternary complex, and subsequently, the 43S complex (1) REACT_1079
Formation of tubulin folding intermediates by CCT/TriC (1) REACT_16956
Free fatty acid receptors (3) REACT_21268
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
GABA synthesis (1) REACT_24020
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (7) REACT_19231
G alpha (q) signalling events (8) REACT_18283
G alpha (s) signalling events (2) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Gluconeogenesis (8) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (16) REACT_6960
Glycolysis (3) REACT_1383
Glyoxylate metabolism (4) REACT_16925
Golgi Associated Vesicle Biogenesis (1) REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (1) REACT_1100
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GRB2:SOS provides linkage to MAPK signaling for Integrins (1) REACT_15443
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Highly calcium permeable nicotinic acetylcholine receptors (1) REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1) REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1) REACT_22223
Histidine catabolism (1) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interleukin receptor SHC signaling (1) REACT_23891
Kinesins (1) REACT_25201
L13a-mediated translational silencing of Ceruloplasmin expression (1) REACT_79
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (3) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
MEK activation (1) REACT_962
Metabolism of folate and pterines (3) REACT_11167
Methionine salvage pathway (2) REACT_75881
Methylation (3) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (16) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (4) REACT_25073
mRNA Capping (1) REACT_1470
mTOR signalling (1) REACT_6838
Muscarinic acetylcholine receptors (1) REACT_16943
Na+/Cl- dependent neurotransmitter transporters (16) REACT_20506
NADPH regeneration (1) REACT_16904
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
Neurotransmitter Clearance In The Synaptic Cleft (2) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
Organic anion transport (2) REACT_22310
Organic anion transporters (7) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
p130Cas linkage to MAPK signaling for integrins (1) REACT_15381
p38MAPK events (1) REACT_12065
PCP/CE pathway (1) REACT_172581
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
PKA activation in glucagon signalling (1) REACT_1946
Platelet degranulation (1) REACT_318
PLC beta mediated events (1) REACT_15426
Post-chaperonin tubulin folding pathway (1) REACT_16967
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton-coupled monocarboxylate transport (3) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (16) REACT_19328
Purine catabolism (3) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (3) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (2) REACT_2071
RAF activation (1) REACT_2077
RAF phosphorylates MEK (1) REACT_614
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (3) REACT_20546
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (2) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of insulin secretion (1) REACT_18325
Regulation of PLK1 Activity at G2/M Transition (1) REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Release of eIF4E (1) REACT_6836
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Retrograde neurotrophin signalling (1) REACT_12435
Reuptake of GABA (1) REACT_23910
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
Ribosomal scanning and start codon recognition (1) REACT_931
Role of phospholipids in phagocytosis (1) REACT_160158
S6K1-mediated signalling (1) REACT_6754
Scavenging by Class A Receptors (1) REACT_163699
Sema3A PAK dependent Axon repulsion (1) REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (3) REACT_115789
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Sialic acid metabolism (1) REACT_200874
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (2) REACT_115810
STING mediated induction of host immune responses (1) REACT_147841
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (6) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (3) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of PIPs at the Golgi membrane (1) REACT_120836
Synthesis of PS (3) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The fatty acid cycling model (1) REACT_6258
The proton buffering model (1) REACT_6196
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (2) REACT_15292
Tie2 Signaling (1) REACT_12621
Transcriptional regulation by small RNAs (1) REACT_267668
Translation initiation complex formation (1) REACT_1979
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5) REACT_1206
Tryptophan catabolism (4) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (2) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (2) REACT_25012
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