ST000241 Cyclobutene- and cyclobutane-functionalized fatty acids as novel biochemical probes of structure and function in HepG2 cells
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
ABC-family proteins mediated transport (1) REACT_15480
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Adenosine P1 receptors (1) REACT_18288
Biosynthesis of A2E, implicated in retinal degradation (1) REACT_160194
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (1) REACT_24941
Cytosolic sulfonation of small molecules (1) REACT_6913
Digestion of dietary lipid (2) REACT_9518
Endogenous sterols (1) REACT_13812
eNOS activation (1) REACT_12477
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (4) REACT_21268
G alpha (i) signalling events (1) REACT_19231
G alpha (q) signalling events (3) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Gluconeogenesis (1) REACT_1520
Glutathione synthesis and recycling (1) REACT_6960
Glycolysis (1) REACT_1383
Heme biosynthesis (1) REACT_9465
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
IPs transport between cytosol and ER lumen (1) REACT_150204
IPs transport between ER lumen and cytosol (1) REACT_150405
IPs transport between ER lumen and nucleus (1) REACT_150164
IPs transport between nucleus and cytosol (1) REACT_150458
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (1) REACT_14820
Methylation (1) REACT_6946
Miscellaneous substrates (1) REACT_13425
NGF-independant TRKA activation (1) REACT_11046
Orphan transporters (2) REACT_267716
Plasmalogen biosynthesis (1) REACT_1407
PPARA activates gene expression (1) REACT_116145
Prostanoid ligand receptors (1) REACT_18425
Purine catabolism (1) REACT_2086
Purine salvage (1) REACT_1923
Pyrimidine biosynthesis (1) REACT_21376
Pyrimidine catabolism (1) REACT_1023
Recycling of bile acids and salts (1) REACT_11042
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid cycle disease events (2) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
REV-ERBA represses gene expression (1) REACT_118789
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Serine biosynthesis (1) REACT_115789
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (2) REACT_115639
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of IPs in the ER lumen (1) REACT_150253
Synthesis of IPs in the nucleus (1) REACT_150275
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of pyrophosphates in the cytosol (1) REACT_150188
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (4) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (3) REACT_23892
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Transport of organic anions (2) REACT_23988
Vitamin D (calciferol) metabolism (1) REACT_13523
Vitamins (1) REACT_13450
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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