ST000270 Metabolomics in AML
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (3) REACT_121117
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (17) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (15) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (15) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (3) REACT_197
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (3) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COX reactions (1) REACT_1396
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (15) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (15) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (2) REACT_23964
Digestion of dietary lipid (1) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (15) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (15) REACT_111178
Fatty acids (1) REACT_13814
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
Free fatty acid receptors (1) REACT_21268
Fructose catabolism (1) REACT_1571
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (1) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (2) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (3) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (16) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme biosynthesis (2) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (3) REACT_1249
HS-GAG degradation (1) REACT_120752
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Ligand-gated ion channel transport (2) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Metabolism of folate and pterines (2) REACT_11167
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
Miscellaneous substrates (1) REACT_13425
Mitochondrial tRNA aminoacylation (15) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (18) REACT_20506
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
phospho-PLA2 pathway (1) REACT_15466
PPARA activates gene expression (2) REACT_116145
Proline catabolism (1) REACT_1002
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (15) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (3) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (3) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (3) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Retinoid metabolism and transport (1) REACT_24968
Reuptake of GABA (2) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (2) REACT_118659
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (3) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (1) REACT_15292
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6) REACT_1206
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (2) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (3) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated vascular permeability (2) REACT_228016
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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