ST000307 Targeting CRBN to alter CD8 T cell metabolism
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (2) REACT_121117
Activation of the phototransduction cascade (1) REACT_163932
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (1) REACT_238
Amino acid transport across the plasma membrane (4) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (4) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (4) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Ca2+ pathway (1) REACT_172761
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
cGMP effects (1) REACT_23767
Citric acid cycle (TCA cycle) (1) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (1) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (4) REACT_111056
Cytosolic tRNA aminoacylation (4) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (1) REACT_23964
Endosomal/Vacuolar pathway (4) REACT_111168
ER-Phagosome pathway (4) REACT_111178
G alpha (i) signalling events (2) REACT_19231
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (4) REACT_6960
Glyoxylate metabolism (1) REACT_16925
HDMs demethylate histones (1) REACT_228178
Histidine catabolism (1) REACT_1249
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Methionine salvage pathway (2) REACT_75881
Methylation (1) REACT_6946
Mitochondrial tRNA aminoacylation (4) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
mRNA Capping (1) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (4) REACT_20506
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (1) REACT_11088
Organic anion transport (1) REACT_22310
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
Phenylalanine and tyrosine catabolism (2) REACT_1786
Proton/oligonucleotide cotransporters (4) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (1) REACT_21376
Pyrimidine catabolism (3) REACT_1023
Pyrimidine salvage reactions (3) REACT_655
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Scavenging by Class A Receptors (1) REACT_163699
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (1) REACT_15292
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Tryptophan catabolism (1) REACT_916
Urea cycle (1) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
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