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ST000313 Muscle Clock knock out mice metabolic changes (iMSBmal1-Exp1)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2)
REACT_850
Abacavir metabolism (5)
REACT_121388
Abacavir transmembrane transport (2)
REACT_120801
ABCA transporters in lipid homeostasis (2)
REACT_111158
ABC-family proteins mediated transport (2)
REACT_15480
ABH2 mediated Reversal of Alkylation Damage (1)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (1)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (2)
REACT_160183
Abnormal metabolism in phenylketonuria (4)
REACT_121117
Acetylation (1)
REACT_6732
Acetylcholine Neurotransmitter Release Cycle (3)
REACT_15309
Acetylcholine regulates insulin secretion (2)
REACT_18405
Activated point mutants of FGFR2 (2)
REACT_120863
activated TAK1 mediates p38 MAPK activation (2)
REACT_21399
Activation of ATR in response to replication stress (2)
REACT_6769
Activation of BAD and translocation to mitochondria (2)
REACT_549
Activation of CaMK IV (2)
REACT_20652
Activation of caspases through apoptosome-mediated cleavage (2)
REACT_607
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (2)
REACT_25148
Activation of NF-kappaB in B cells (2)
REACT_118656
Activation of NIMA Kinases NEK9, NEK6, NEK7 (2)
REACT_160122
Activation of PKB (2)
REACT_790
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (3)
REACT_200686
Activation of RAS in B cells (2)
REACT_118778
Activation of the AP-1 family of transcription factors (2)
REACT_21326
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (2)
REACT_1258
Activation of the pre-replicative complex (2)
REACT_1095
Adenylate cyclase activating pathway (1)
REACT_15312
Adherens junctions interactions (1)
REACT_19195
ADP signalling through P2Y purinoceptor 1 (2)
REACT_19140
ADP signalling through P2Y purinoceptor 12 (1)
REACT_20653
Aflatoxin activation and detoxification (2)
REACT_228214
AKT-mediated inactivation of FOXO1A (2)
REACT_13655
AKT phosphorylates targets in the cytosol (2)
REACT_12564
AKT phosphorylates targets in the nucleus (2)
REACT_12442
alpha-linolenic acid (ALA) metabolism (8)
REACT_121147
Alpha-oxidation of phytanate (5)
REACT_17003
Amino acid synthesis and interconversion (transamination) (8)
REACT_238
AMPK inhibits chREBP transcriptional activation activity (3)
REACT_1988
Androgen biosynthesis (3)
REACT_11059
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (2)
REACT_118700
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (2)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (2)
REACT_75842
ARMS-mediated activation (2)
REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Association of TriC/CCT with target proteins during biosynthesis (1)
REACT_16907
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Asymmetric localization of PCP proteins (2)
REACT_172638
ATM mediated phosphorylation of repair proteins (2)
REACT_1924
ATM mediated response to DNA double-strand break (2)
REACT_204
ATP sensitive Potassium channels (1)
REACT_75775
Attenuation phase (1)
REACT_200624
Autodegradation of the E3 ubiquitin ligase COP1 (2)
REACT_20549
Beta-catenin phosphorylation cascade (2)
REACT_11065
betaKlotho-mediated ligand binding (2)
REACT_111046
Beta oxidation of butanoyl-CoA to acetyl-CoA (3)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (4)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (4)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (4)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (4)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (4)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (4)
REACT_2025
Beta-oxidation of pristanoyl-CoA (4)
REACT_17017
Beta-oxidation of very long chain fatty acids (4)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biotin transport and metabolism (2)
REACT_11153
Branched-chain amino acid catabolism (7)
REACT_197
Butyrate Response Factor 1 (BRF1) destabilizes mRNA (2)
REACT_24915
Ca2+ pathway (2)
REACT_172761
Calmodulin induced events (2)
REACT_9000
CaMK IV-mediated phosphorylation of CREB (2)
REACT_15502
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (3)
REACT_2125
CD28 co-stimulation (2)
REACT_19183
CD28 dependent PI3K/Akt signaling (2)
REACT_19358
CD28 dependent Vav1 pathway (2)
REACT_19238
CDK-mediated phosphorylation and removal of Cdc6 (2)
REACT_1221
CDO in myogenesis (2)
REACT_21402
Cell-extracellular matrix interactions (1)
REACT_20649
Cell redox homeostasis (4)
REACT_121394
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (2)
REACT_407
CHL1 interactions (1)
REACT_22292
Cholesterol biosynthesis (7)
REACT_9405
Citric acid cycle (TCA cycle) (9)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Clearance of Nuclear Envelope Membranes from Chromatin (2)
REACT_160251
Cobalamin (Cbl, vitamin B12) transport and metabolism (6)
REACT_163862
Coenzyme A biosynthesis (3)
REACT_11218
Collagen biosynthesis and modifying enzymes (1)
REACT_121139
Condensation of Prometaphase Chromosomes (2)
REACT_150260
Condensation of Prophase Chromosomes (3)
REACT_172744
Conjugation of benzoate with glycine (2)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (2)
REACT_6812
Constitutive PI3K/AKT Signaling in Cancer (2)
REACT_147727
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (2)
REACT_160254
Constitutive Signaling by NOTCH1 PEST Domain Mutants (2)
REACT_160243
Creatine metabolism (2)
REACT_813
CREB phosphorylation (2)
REACT_12524
CREB phosphorylation through the activation of Adenylate Cyclase (2)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
CREB phosphorylation through the activation of CaMKK (2)
REACT_20661
CREB phosphorylation through the activation of Ras (2)
REACT_20568
CRMPs in Sema3A signaling (2)
REACT_19199
Cross-presentation of particulate exogenous antigens (phagosomes) (1)
REACT_111174
c-src mediated regulation of Cx43 function and closure of gap junctions (2)
REACT_11043
CTLA4 inhibitory signaling (2)
REACT_19405
Cyclin A/B1 associated events during G2/M transition (2)
REACT_1857
Cyclin A:Cdk2-associated events at S phase entry (2)
REACT_9029
Cyclin B2 mediated events (2)
REACT_2101
Cyclin D associated events in G1 (2)
REACT_821
Cyclin E associated events during G1/S transition (2)
REACT_1574
CYP2E1 reactions (1)
REACT_13797
Cytosolic iron-sulfur cluster assembly (2)
REACT_160176
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (2)
REACT_15306
DAG and IP3 signaling (2)
REACT_111064
DAP12 signaling (2)
REACT_147814
DARPP-32 events (3)
REACT_15334
DCC mediated attractive signaling (2)
REACT_22351
deactivation of the beta-catenin transactivating complex (2)
REACT_200731
Deadenylation of mRNA (1)
REACT_20514
Defective HLCS causes multiple carboxylase deficiency (1)
REACT_169312
Defective MMAB causes methylmalonic aciduria type cblB (1)
REACT_169318
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
Defective PAPSS2 causes SEMD-PA (1)
REACT_267645
degradation of AXIN (1)
REACT_200766
Degradation of beta-catenin by the destruction complex (2)
REACT_11063
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (3)
REACT_23964
Degradation of GLI1 by the proteasome (2)
REACT_267605
Degradation of GLI2 by the proteasome (2)
REACT_206597
Depolymerisation of the Nuclear Lamina (2)
REACT_200828
Detoxification of Reactive Oxygen Species (4)
REACT_172715
disassembly of the destruction complex and recruitment of AXIN to the membrane (2)
REACT_200610
Disinhibition of SNARE formation (2)
REACT_1178
DNA Damage/Telomere Stress Induced Senescence (2)
REACT_169185
Dopamine Neurotransmitter Release Cycle (2)
REACT_15293
Downregulation of ERBB2:ERBB3 signaling (2)
REACT_115662
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Downstream signal transduction (2)
REACT_17025
Downstream TCR signaling (2)
REACT_12555
DSCAM interactions (2)
REACT_25299
Effects of PIP2 hydrolysis (2)
REACT_2202
EGFR downregulation (2)
REACT_12484
EGFR interacts with phospholipase C-gamma (2)
REACT_12478
Eicosanoids (1)
REACT_13645
Electron transport from NADPH to Ferredoxin (2)
REACT_150128
Elevation of cytosolic Ca2+ levels (1)
REACT_162
Endogenous sterols (1)
REACT_13812
Endosomal Sorting Complex Required For Transport (ESCRT) (2)
REACT_27258
eNOS activation (4)
REACT_12477
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHA-mediated growth cone collapse (2)
REACT_228063
EPHB-mediated forward signaling (2)
REACT_228085
EPH-ephrin mediated repulsion of cells (2)
REACT_228189
EPH-Ephrin signaling (2)
REACT_228170
Ephrin signaling (2)
REACT_228226
ERK1 activation (2)
REACT_1391
ERK2 activation (2)
REACT_1183
ERK/MAPK targets (2)
REACT_12599
ER-Phagosome pathway (2)
REACT_111178
Establishment of Sister Chromatid Cohesion (1)
REACT_150266
Estrogen biosynthesis (1)
REACT_11037
Ethanol oxidation (5)
REACT_34
Factors involved in megakaryocyte development and platelet production (3)
REACT_24970
Fatty acids (1)
REACT_13814
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (4)
REACT_1319
Fc epsilon receptor (FCERI) signaling (2)
REACT_163936
FCERI mediated Ca+2 mobilization (2)
REACT_163834
FCERI mediated MAPK activation (2)
REACT_163701
FCERI mediated NF-kB activation (3)
REACT_163994
FCGR activation (2)
REACT_160274
FGFR1b ligand binding and activation (2)
REACT_9400
FGFR1c and Klotho ligand binding and activation (2)
REACT_9484
FGFR1c ligand binding and activation (2)
REACT_9515
FGFR2b ligand binding and activation (2)
REACT_9416
FGFR2c ligand binding and activation (2)
REACT_9413
FGFR3b ligand binding and activation (2)
REACT_9508
FGFR3c ligand binding and activation (2)
REACT_9510
FGFR4 ligand binding and activation (2)
REACT_9452
FMO oxidises nucleophiles (2)
REACT_13653
Folding of actin by CCT/TriC (2)
REACT_17050
Formation of apoptosome (2)
REACT_89
Formation of ATP by chemiosmotic coupling (2)
REACT_6759
Formation of HIV-1 elongation complex containing HIV-1 Tat (2)
REACT_6346
Formation of the active cofactor, UDP-glucuronate (2)
REACT_6737
formation of the beta-catenin:TCF transactivating complex (1)
REACT_200753
Formation of tubulin folding intermediates by CCT/TriC (2)
REACT_16956
Frs2-mediated activation (2)
REACT_12076
FRS2-mediated cascade (2)
REACT_21247
Fructose catabolism (2)
REACT_1571
G0 and Early G1 (2)
REACT_111214
G2/M DNA damage checkpoint (2)
REACT_897
G2/M DNA replication checkpoint (2)
REACT_1846
G2 Phase (2)
REACT_1915
GAB1 signalosome (2)
REACT_12578
Galactose catabolism (3)
REACT_532
G alpha (i) signalling events (3)
REACT_19231
G alpha (q) signalling events (2)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
G alpha (z) signalling events (1)
REACT_19333
Gastrin-CREB signalling pathway via PKC and MAPK (2)
REACT_120966
G beta:gamma signalling through PI3Kgamma (2)
REACT_19290
Generation of second messenger molecules (2)
REACT_12623
GLI3 is processed to GLI3R by the proteasome (2)
REACT_231645
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1)
REACT_18274
Glucocorticoid biosynthesis (3)
REACT_11036
Gluconeogenesis (9)
REACT_1520
Glucose transport (2)
REACT_212
Glutathione synthesis and recycling (2)
REACT_6960
Glycogen breakdown (glycogenolysis) (3)
REACT_1008
Glycolysis (8)
REACT_1383
Glycosphingolipid metabolism (4)
REACT_116105
Glyoxylate metabolism (3)
REACT_16925
Golgi Associated Vesicle Biogenesis (2)
REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (2)
REACT_1100
GPVI-mediated activation cascade (2)
REACT_1695
Growth hormone receptor signaling (2)
REACT_111133
HATs acetylate histones (1)
REACT_172610
HDL-mediated lipid transport (2)
REACT_13621
HDMs demethylate histones (1)
REACT_228178
Hedgehog ligand biogenesis (2)
REACT_228111
Hedgehog 'off' state (1)
REACT_267634
Heme biosynthesis (1)
REACT_9465
Heme degradation (1)
REACT_22297
Hh ligand biogenesis disease (2)
REACT_228209
Histidine catabolism (1)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2)
REACT_494
HSF1-dependent transactivation (2)
REACT_200775
HS-GAG degradation (1)
REACT_120752
HuR stabilizes mRNA (2)
REACT_25218
Hypusine synthesis from eIF5A-lysine (2)
REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (3)
REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (2)
REACT_163919
Inhibition of TSC complex formation by PKB (2)
REACT_6743
Integrin alphaIIb beta3 signaling (2)
REACT_15523
Interaction between L1 and Ankyrins (2)
REACT_22266
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2)
REACT_25367
Interconversion of polyamines (2)
REACT_14805
Interferon alpha/beta signaling (2)
REACT_25162
Interferon gamma signaling (2)
REACT_25078
Interleukin-1 signaling (2)
REACT_22442
Interleukin-2 signaling (2)
REACT_27283
Interleukin-3, 5 and GM-CSF signaling (2)
REACT_23837
Interleukin-6 signaling (2)
REACT_27307
Interleukin-7 signaling (2)
REACT_115529
Interleukin receptor SHC signaling (2)
REACT_23891
Ion transport by P-type ATPases (2)
REACT_25149
IRAK1 recruits IKK complex (2)
REACT_24918
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (2)
REACT_25354
IRAK2 mediated activation of TAK1 complex (2)
REACT_25380
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (2)
REACT_25018
IRE1alpha activates chaperones (2)
REACT_18368
IRF3 mediated activation of type 1 IFN (2)
REACT_118811
IRF3-mediated induction of type I IFN (2)
REACT_163993
Iron uptake and transport (3)
REACT_25060
IRS activation (2)
REACT_570
IRS-related events triggered by IGF1R (2)
REACT_150203
ISG15 antiviral mechanism (2)
REACT_115831
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (2)
REACT_21368
Kinesins (2)
REACT_25201
KSRP destabilizes mRNA (2)
REACT_25042
L1CAM interactions (2)
REACT_22205
Linoleic acid (LA) metabolism (6)
REACT_121100
Loss of Nlp from mitotic centrosomes (2)
REACT_15364
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (2)
REACT_163743
Lysine catabolism (5)
REACT_1298
Lysosome Vesicle Biogenesis (2)
REACT_19287
MASTL Facilitates Mitotic Progression (2)
REACT_150182
Meiotic synapsis (2)
REACT_75792
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of nucleotides (1)
REACT_1698
Metabolism of serotonin (3)
REACT_15532
Methylation (4)
REACT_6946
MHC class II antigen presentation (2)
REACT_121399
Mineralocorticoid biosynthesis (3)
REACT_11047
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (3)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (3)
REACT_228145
Mitochondrial ABC transporters (2)
REACT_111108
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (4)
REACT_160
Mitochondrial protein import (2)
REACT_118595
Mitochondrial tRNA aminoacylation (2)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
MPS IIIC - Sanfilippo syndrome C (1)
REACT_147860
mRNA 3'-end processing (1)
REACT_1849
mRNA decay by 3' to 5' exoribonuclease (1)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1)
REACT_20518
Mtb iron assimilation by chelation (1)
REACT_121118
MyD88 cascade initiated on plasma membrane (2)
REACT_27215
MyD88 dependent cascade initiated on endosome (2)
REACT_25222
MyD88:Mal cascade initiated on plasma membrane (2)
REACT_6788
NADPH regeneration (2)
REACT_16904
NCAM1 interactions (1)
REACT_18312
NCAM signaling for neurite out-growth (2)
REACT_18334
Negative regulation of FGFR signaling (2)
REACT_111184
Negative regulators of RIG-I/MDA5 signaling (1)
REACT_25271
Nephrin interactions (2)
REACT_23832
Netrin-1 signaling (2)
REACT_22237
Netrin mediated repulsion signals (2)
REACT_22384
Neurofascin interactions (2)
REACT_22312
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (1)
REACT_25039
NF-kB is activated and signals survival (2)
REACT_13696
Nicotinate metabolism (5)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
NOD1/2 Signaling Pathway (2)
REACT_75776
Nonhomologous End-joining (NHEJ) (2)
REACT_1022
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (2)
REACT_75822
Norepinephrine Neurotransmitter Release Cycle (3)
REACT_15418
NOSIP mediated eNOS trafficking (1)
REACT_12510
NOSTRIN mediated eNOS trafficking (1)
REACT_12541
NOTCH1 Intracellular Domain Regulates Transcription (2)
REACT_118780
NRAGE signals death through JNK (2)
REACT_13638
NRIF signals cell death from the nucleus (2)
REACT_13643
Nuclear Pore Complex (NPC) Disassembly (2)
REACT_163931
Oncogene Induced Senescence (2)
REACT_169325
Orc1 removal from chromatin (2)
REACT_1156
Organic anion transport (1)
REACT_22310
Organic anion transporters (1)
REACT_19372
Orphan transporters (3)
REACT_267716
Oxidative Stress Induced Senescence (3)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_120916
p130Cas linkage to MAPK signaling for integrins (2)
REACT_15381
P2Y receptors (2)
REACT_18289
p38MAPK events (2)
REACT_12065
p53-Independent DNA Damage Response (2)
REACT_2160
p75NTR recruits signalling complexes (2)
REACT_13415
PAOs oxidise polyamines to amines (1)
REACT_505
PCP/CE pathway (2)
REACT_172581
PD-1 signaling (2)
REACT_19324
PDE3B signalling (3)
REACT_1451
PECAM1 interactions (2)
REACT_12519
Pentose phosphate pathway (hexose monophosphate shunt) (1)
REACT_1859
PERK regulates gene expression (2)
REACT_18277
Peroxisomal lipid metabolism (1)
REACT_16957
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
Phospholipase C-mediated cascade (2)
REACT_21310
phospho-PLA2 pathway (2)
REACT_15466
Phosphorylation of CD3 and TCR zeta chains (2)
REACT_12582
Phosphorylation of Emi1 (2)
REACT_6875
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (2)
REACT_308
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes (2)
REACT_6362
PI3K/AKT activation (2)
REACT_12464
PI-3K cascade (2)
REACT_21270
PI3K Cascade (2)
REACT_976
PI3K events in ERBB2 signaling (2)
REACT_116008
PI3K events in ERBB4 signaling (2)
REACT_115961
PIP3 activates AKT signaling (2)
REACT_75829
PKA activation (1)
REACT_15530
PKA activation in glucagon signalling (1)
REACT_1946
PKA-mediated phosphorylation of CREB (2)
REACT_15497
PKA-mediated phosphorylation of key metabolic factors (2)
REACT_1525
Plasmalogen biosynthesis (2)
REACT_1407
Platelet degranulation (2)
REACT_318
Platelet homeostasis (1)
REACT_23876
Platelet sensitization by LDL (2)
REACT_23879
PLCG1 events in ERBB2 signaling (2)
REACT_115720
Polo-like kinase mediated events (2)
REACT_1006
Polymerase switching (2)
REACT_1792
Polymerase switching on the C-strand of the telomere (2)
REACT_7987
Prefoldin mediated transfer of substrate to CCT/TriC (1)
REACT_16936
Pregnenolone biosynthesis (1)
REACT_11038
Prolactin receptor signaling (2)
REACT_115697
Proline catabolism (3)
REACT_1002
Propionyl-CoA catabolism (2)
REACT_993
Proton-coupled monocarboxylate transport (1)
REACT_20515
Purine catabolism (3)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5)
REACT_1776
Purine salvage (4)
REACT_1923
Pyrimidine biosynthesis (2)
REACT_21376
Pyrimidine catabolism (4)
REACT_1023
Pyrimidine salvage reactions (2)
REACT_655
Pyruvate metabolism (5)
REACT_2071
RAF activation (2)
REACT_2077
RAF phosphorylates MEK (2)
REACT_614
Rap1 signalling (2)
REACT_23898
Recruitment of NuMA to mitotic centrosomes (2)
REACT_15510
Recycling of bile acids and salts (3)
REACT_11042
Recycling pathway of L1 (2)
REACT_22365
Regulation of actin dynamics for phagocytic cup formation (2)
REACT_160086
Regulation of AMPK activity via LKB1 (3)
REACT_21285
Regulation of APC/C activators between G1/S and early anaphase (2)
REACT_6837
Regulation of HSF1-mediated heat shock response (3)
REACT_200780
Regulation of insulin secretion (2)
REACT_18325
Regulation of KIT signaling (2)
REACT_111225
Regulation of PLK1 Activity at G2/M Transition (2)
REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (6)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (3)
REACT_21393
Regulation of signaling by CBL (2)
REACT_23787
Regulation of thyroid hormone activity (1)
REACT_15297
Release of eIF4E (2)
REACT_6836
Removal of the Flap Intermediate (1)
REACT_70
Removal of the Flap Intermediate from the C-strand (1)
REACT_7999
Resolution of Sister Chromatid Cohesion (3)
REACT_150425
Respiratory electron transport (4)
REACT_22393
Retinoid cycle disease events (2)
REACT_160130
Retinoid metabolism and transport (1)
REACT_24968
Ribosomal scanning and start codon recognition (2)
REACT_931
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways (1)
REACT_25359
RIP-mediated NFkB activation via ZBP1 (2)
REACT_118563
RMTs methylate histone arginines (2)
REACT_228108
RNA Polymerase II Transcription Initiation And Promoter Clearance (2)
REACT_834
RNA Polymerase I Promoter Opening (1)
REACT_2232
RNA Polymerase I Transcription Initiation (1)
REACT_953
Role of Abl in Robo-Slit signaling (2)
REACT_19230
Role of DCC in regulating apoptosis (2)
REACT_22128
Role of LAT2/NTAL/LAB on calcium mobilization (2)
REACT_163769
Role of phospholipids in phagocytosis (2)
REACT_160158
Role of second messengers in netrin-1 signaling (2)
REACT_22228
RSK activation (2)
REACT_20510
S33 mutants of beta-catenin aren't phosphorylated (1)
REACT_228159
S37 mutants of beta-catenin aren't phosphorylated (1)
REACT_228251
S45 mutants of beta-catenin aren't phosphorylated (1)
REACT_228137
S6K1-mediated signalling (2)
REACT_6754
S6K1 signalling (2)
REACT_6772
SCF(Skp2)-mediated degradation of p27/p21 (2)
REACT_9003
Sema3A PAK dependent Axon repulsion (2)
REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (2)
REACT_19279
Sema4D induced cell migration and growth-cone collapse (2)
REACT_19277
Sema4D mediated inhibition of cell attachment and migration (2)
REACT_19266
Senescence-Associated Secretory Phenotype (SASP) (2)
REACT_169168
Separation of Sister Chromatids (1)
REACT_150471
Serine biosynthesis (4)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Serotonin Neurotransmitter Release Cycle (2)
REACT_15425
SHC1 events in EGFR signaling (2)
REACT_12579
SHC1 events in ERBB2 signaling (2)
REACT_115993
SHC1 events in ERBB4 signaling (2)
REACT_116005
SHC activation (2)
REACT_1661
SHC-mediated cascade (2)
REACT_21374
SHC-related events triggered by IGF1R (2)
REACT_150139
Sialic acid metabolism (3)
REACT_200874
Signal attenuation (2)
REACT_508
Signaling by activated point mutants of FGFR1 (2)
REACT_121153
Signaling by activated point mutants of FGFR3 (2)
REACT_121337
Signaling by Activin (2)
REACT_150238
Signaling by BMP (2)
REACT_12034
Signaling by constitutively active EGFR (2)
REACT_115852
Signaling by EGFR (2)
REACT_9417
Signaling by ERBB2 (2)
REACT_115755
Signaling by ERBB4 (2)
REACT_115596
Signaling by FGFR (2)
REACT_9470
Signaling by FGFR1 amplification mutants (2)
REACT_120827
Signaling by FGFR1 fusion mutants (2)
REACT_121141
Signaling by FGFR2 amplification mutants (2)
REACT_121255
Signaling by FGFR4 mutants (2)
REACT_121286
Signaling by FGFR mutants (2)
REACT_121398
Signaling by Hippo (2)
REACT_118607
Signaling by Insulin receptor (2)
REACT_498
Signaling by Leptin (2)
REACT_169118
Signaling by NODAL (2)
REACT_111057
Signaling by PDGF (2)
REACT_16888
Signaling by SCF-KIT (2)
REACT_111040
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (2)
REACT_150359
Signalling to ERK5 (2)
REACT_12020
Signalling to STAT3 (2)
REACT_12049
Signal regulatory protein (SIRP) family interactions (2)
REACT_23916
Signal transduction by L1 (2)
REACT_22272
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
SMAD2/3 MH2 Domain Mutants in Cancer (2)
REACT_169165
SMAD2/3 Phosphorylation Motif Mutants in Cancer (1)
REACT_169103
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (2)
REACT_120734
Smooth Muscle Contraction (2)
REACT_20558
Sphingolipid de novo biosynthesis (5)
REACT_115810
Spry regulation of FGF signaling (2)
REACT_111080
Stabilization of p53 (2)
REACT_309
STAT6-mediated induction of chemokines (2)
REACT_163734
Sterols are 12-hydroxylated by CYP8B1 (1)
REACT_13438
Stimulation of the cell death response by PAK-2p34 (2)
REACT_13532
Stimuli-sensing channels (2)
REACT_160189
STING mediated induction of host immune responses (1)
REACT_147841
Striated Muscle Contraction (2)
REACT_16969
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (4)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (2)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (5)
REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (3)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts (1)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (5)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (3)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7)
REACT_11041
Synthesis of Dolichyl-phosphate (3)
REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of IP2, IP, and Ins in the cytosol (2)
REACT_150352
Synthesis of IP3 and IP4 in the cytosol (2)
REACT_150312
Synthesis of IPs in the nucleus (2)
REACT_150275
Synthesis of Ketone Bodies (3)
REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of Lipoxins (LX) (3)
REACT_150320
Synthesis of PA (2)
REACT_120906
Synthesis of PC (3)
REACT_121238
Synthesis of PE (2)
REACT_120919
Synthesis of PIPs at the early endosome membrane (2)
REACT_120756
Synthesis of PIPs at the ER membrane (2)
REACT_121168
Synthesis of PIPs at the Golgi membrane (2)
REACT_120836
Synthesis of PIPs at the late endosome membrane (2)
REACT_120918
Synthesis of PIPs at the plasma membrane (2)
REACT_121025
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3)
REACT_150149
Synthesis of pyrophosphates in the cytosol (2)
REACT_150188
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3)
REACT_380
t(4;14) translocations of FGFR3 (2)
REACT_121011
T41 mutants of beta-catenin aren't phosphorylated (1)
REACT_228261
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (2)
REACT_21281
TET1,2,3 and TDG demethylate DNA (1)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (4)
REACT_111176
TGF-beta receptor signaling activates SMADs (2)
REACT_120850
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (2)
REACT_120726
TGFBR1 KD Mutants in Cancer (2)
REACT_169263
TGFBR2 Kinase Domain Mutants in Cancer (1)
REACT_169440
The activation of arylsulfatases (2)
REACT_121036
The canonical retinoid cycle in rods (twilight vision) (5)
REACT_160156
The NLRP1 inflammasome (1)
REACT_75927
The NLRP3 inflammasome (1)
REACT_75808
The proton buffering model (2)
REACT_6196
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (1)
REACT_15292
Tie2 Signaling (2)
REACT_12621
Tolerance by Mtb to nitric oxide produced by macrophages (2)
REACT_120983
TRAF3-dependent IRF activation pathway (2)
REACT_25026
TRAF6 mediated induction of TAK1 complex (2)
REACT_25351
TRAF6 mediated IRF7 activation (2)
REACT_24938
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (2)
REACT_25120
TRAF6 mediated NF-kB activation (2)
REACT_24969
Trafficking and processing of endosomal TLR (2)
REACT_118632
Trafficking of AMPA receptors (2)
REACT_18307
Trafficking of dietary sterols (2)
REACT_13781
Trafficking of GluR2-containing AMPA receptors (2)
REACT_18422
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcription of the HIV genome (2)
REACT_6233
Transferrin endocytosis and recycling (2)
REACT_25283
Translocation of GLUT4 to the plasma membrane (3)
REACT_147867
Translocation of ZAP-70 to Immunological synapse (2)
REACT_12596
Transport and synthesis of PAPS (2)
REACT_6840
Transport of vitamins, nucleosides, and related molecules (1)
REACT_22285
Triglyceride Biosynthesis (4)
REACT_1190
Tristetraprolin (TTP) destabilizes mRNA (2)
REACT_25064
TRKA activation by NGF (2)
REACT_11060
Tryptophan catabolism (5)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Ubiquitin-dependent degradation of Cyclin D1 (2)
REACT_4
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (2)
REACT_1614
Uptake and function of anthrax toxins (1)
REACT_228255
Urea cycle (4)
REACT_847
Utilization of Ketone Bodies (3)
REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1)
REACT_24023
VEGFA-VEGFR2 Pathway (4)
REACT_228166
VEGFR2 mediated cell proliferation (2)
REACT_228024
VEGFR2 mediated vascular permeability (4)
REACT_228016
Vitamin B1 (thiamin) metabolism (3)
REACT_11117
Vitamin B2 (riboflavin) metabolism (4)
REACT_11070
Vitamin C (ascorbate) metabolism (3)
REACT_11202
Vitamin D (calciferol) metabolism (1)
REACT_13523
Vitamins (1)
REACT_13450
Vitamins B6 activation to pyridoxal phosphate (3)
REACT_25012
WNT5A-dependent internalization of FZD4 (2)
REACT_172599
WNT mediated activation of DVL (2)
REACT_200668
Xenobiotics (1)
REACT_13543
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