ST000405 Metabolomic Profiling in Early Pregnancy using Pre-Diagnostic Sera from Women Who Developed Placental Abruption
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abnormal metabolism in phenylketonuria (5) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (20) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (4) REACT_197
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (3) REACT_15551
Citric acid cycle (TCA cycle) (1) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (19) REACT_15306
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (1) REACT_23964
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Endosomal/Vacuolar pathway (19) REACT_111168
eNOS activation (1) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (19) REACT_111178
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (1) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (7) REACT_18283
G alpha (s) signalling events (3) REACT_19327
Gluconeogenesis (3) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (19) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
Heme biosynthesis (1) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (3) REACT_1249
HS-GAG degradation (1) REACT_120752
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of polyamines (3) REACT_14805
Ligand-gated ion channel transport (2) REACT_25387
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (4) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (19) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (21) REACT_20506
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
Organic anion transporters (1) REACT_19372
Organic cation transport (6) REACT_22357
PAOs oxidise polyamines to amines (3) REACT_505
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Platelet degranulation (1) REACT_318
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (19) REACT_19328
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (1) REACT_1023
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Retinoid metabolism and transport (1) REACT_24968
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (3) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (2) REACT_15292
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2) REACT_1206
Tryptophan catabolism (5) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
VEGFR2 mediated vascular permeability (1) REACT_228016
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