ST000421 ms3076 T1D poor glycemic control and control samples
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (3) REACT_121117
Acetylation (3) REACT_6732
Agmatine biosynthesis (2) REACT_14800
Alpha-oxidation of phytanate (1) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (14) REACT_13796
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (10) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (10) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Branched-chain amino acid catabolism (3) REACT_197
Carnitine synthesis (1) REACT_2125
Citric acid cycle (TCA cycle) (2) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Creatine metabolism (4) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (10) REACT_111056
CYP2E1 reactions (2) REACT_13797
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (6) REACT_6913
Cytosolic tRNA aminoacylation (10) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (1) REACT_23964
Digestion of dietary lipid (1) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (3) REACT_13812
Endosomal/Vacuolar pathway (10) REACT_111168
eNOS activation (1) REACT_12477
ER-Phagosome pathway (10) REACT_111178
Estrogen biosynthesis (1) REACT_11037
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
FMO oxidises nucleophiles (1) REACT_13653
Free fatty acid receptors (1) REACT_21268
Fructose catabolism (1) REACT_1571
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (3) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (1) REACT_1520
Glucuronidation (2) REACT_6784
Glutathione synthesis and recycling (11) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme degradation (2) REACT_22297
Histidine catabolism (2) REACT_1249
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of polyamines (2) REACT_14805
Iron uptake and transport (2) REACT_25060
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (1) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (1) REACT_13425
Mitochondrial tRNA aminoacylation (10) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (12) REACT_20506
Nicotinamide salvaging (1) REACT_11213
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transport (3) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
Proline catabolism (1) REACT_1002
Proton-coupled monocarboxylate transport (3) REACT_20515
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (10) REACT_19328
Purine catabolism (3) REACT_2086
Purine salvage (2) REACT_1923
Pyrimidine catabolism (4) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (2) REACT_2071
Recycling of bile acids and salts (2) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Reuptake of GABA (1) REACT_23910
Scavenging by Class A Receptors (1) REACT_163699
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (3) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (2) REACT_115639
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of PA (1) REACT_120906
Synthesis of PE (1) REACT_120919
Synthesis of PI (1) REACT_121000
Synthesis of PS (1) REACT_120823
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5) REACT_1206
Transport of organic anions (2) REACT_23988
Tryptophan catabolism (4) REACT_916
Urea cycle (3) REACT_847
Utilization of Ketone Bodies (2) REACT_59
VEGFR2 mediated vascular permeability (1) REACT_228016
Xenobiotics (1) REACT_13543
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