ST000422 Type 1 Diabetes good glycemic control and controls samples
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylation (4) REACT_6732
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (14) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (12) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (12) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (4) REACT_197
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Cell redox homeostasis (1) REACT_121394
Cholesterol biosynthesis (1) REACT_9405
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (3) REACT_6933
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (12) REACT_111056
CYP2E1 reactions (2) REACT_13797
Cytosolic sulfonation of small molecules (4) REACT_6913
Cytosolic tRNA aminoacylation (12) REACT_15306
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (2) REACT_23964
Digestion of dietary lipid (1) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (3) REACT_13812
Endosomal/Vacuolar pathway (12) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (12) REACT_111178
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (1) REACT_34
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
FMO oxidises nucleophiles (2) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
Free fatty acid receptors (1) REACT_21268
Fructose catabolism (1) REACT_1571
G alpha (i) signalling events (5) REACT_19231
G alpha (q) signalling events (4) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (3) REACT_1520
Glucuronidation (2) REACT_6784
Glutathione synthesis and recycling (13) REACT_6960
Glycolysis (2) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Glyoxylate metabolism (3) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme biosynthesis (1) REACT_9465
Heme degradation (2) REACT_22297
Histidine catabolism (2) REACT_1249
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (2) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of polyamines (2) REACT_14805
Iron uptake and transport (1) REACT_25060
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (3) REACT_6946
Mineralocorticoid biosynthesis (3) REACT_11047
Miscellaneous substrates (2) REACT_13425
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial tRNA aminoacylation (12) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (14) REACT_20506
Nicotinamide salvaging (1) REACT_11213
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transport (4) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
Proline catabolism (2) REACT_1002
Prostanoid ligand receptors (1) REACT_18425
Proton-coupled monocarboxylate transport (3) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (12) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine catabolism (4) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (3) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (3) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (2) REACT_12528
Respiratory electron transport (1) REACT_22393
Reuptake of GABA (1) REACT_23910
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (3) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (3) REACT_115639
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (4) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2) REACT_150417
Synthesis of Ketone Bodies (2) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (2) REACT_120906
Synthesis of PE (1) REACT_120919
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (1) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (7) REACT_1206
Transport of organic anions (3) REACT_23988
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (4) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (2) REACT_847
Utilization of Ketone Bodies (3) REACT_59
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (2) REACT_25012
Xenobiotics (1) REACT_13543
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