ST000441 Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (4) REACT_850
Abacavir metabolism (8) REACT_121388
Abacavir transmembrane transport (1) REACT_120801
ABCA transporters in lipid homeostasis (1) REACT_111158
ABC-family proteins mediated transport (1) REACT_15480
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (3) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylation (1) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (2) REACT_15309
Acetylcholine regulates insulin secretion (3) REACT_18405
Activated point mutants of FGFR2 (1) REACT_120863
activated TAK1 mediates p38 MAPK activation (1) REACT_21399
Activation of ATR in response to replication stress (1) REACT_6769
Activation of BAD and translocation to mitochondria (1) REACT_549
Activation of CaMK IV (1) REACT_20652
Activation of caspases through apoptosome-mediated cleavage (1) REACT_607
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (1) REACT_25148
Activation of NF-kappaB in B cells (1) REACT_118656
Activation of NIMA Kinases NEK9, NEK6, NEK7 (1) REACT_160122
Activation of PKB (1) REACT_790
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of Rac (2) REACT_19226
Activation of RAS in B cells (3) REACT_118778
Activation of the AP-1 family of transcription factors (1) REACT_21326
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (1) REACT_1258
Activation of the phototransduction cascade (3) REACT_163932
Activation of the pre-replicative complex (1) REACT_1095
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (5) REACT_15312
Adenylate cyclase inhibitory pathway (2) REACT_15333
Adherens junctions interactions (1) REACT_19195
ADP signalling through P2Y purinoceptor 1 (3) REACT_19140
ADP signalling through P2Y purinoceptor 12 (2) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (2) REACT_18339
Aflatoxin activation and detoxification (3) REACT_228214
AKT-mediated inactivation of FOXO1A (1) REACT_13655
AKT phosphorylates targets in the cytosol (1) REACT_12564
AKT phosphorylates targets in the nucleus (1) REACT_12442
alpha-linolenic acid (ALA) metabolism (8) REACT_121147
Alpha-oxidation of phytanate (5) REACT_17003
Amino acid synthesis and interconversion (transamination) (10) REACT_238
Amino acid transport across the plasma membrane (2) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (4) REACT_11059
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (1) REACT_118700
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (3) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (2) REACT_75842
ARMS-mediated activation (3) REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Asymmetric localization of PCP proteins (1) REACT_172638
A tetrasaccharide linker sequence is required for GAG synthesis (2) REACT_121408
ATM mediated phosphorylation of repair proteins (1) REACT_1924
ATM mediated response to DNA double-strand break (1) REACT_204
ATP sensitive Potassium channels (1) REACT_75775
Attenuation phase (1) REACT_200624
Autodegradation of the E3 ubiquitin ligase COP1 (1) REACT_20549
Axonal growth inhibition (RHOA activation) (2) REACT_13815
Axonal growth stimulation (1) REACT_13779
Beta-catenin phosphorylation cascade (1) REACT_11065
betaKlotho-mediated ligand binding (1) REACT_111046
Beta oxidation of butanoyl-CoA to acetyl-CoA (3) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (4) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (4) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (4) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (4) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (4) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (4) REACT_2025
Beta-oxidation of pristanoyl-CoA (4) REACT_17017
Beta-oxidation of very long chain fatty acids (4) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (3) REACT_22433
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (6) REACT_197
Butyrate Response Factor 1 (BRF1) destabilizes mRNA (1) REACT_24915
Ca2+ pathway (4) REACT_172761
Calmodulin induced events (1) REACT_9000
CaMK IV-mediated phosphorylation of CREB (1) REACT_15502
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
CD28 co-stimulation (1) REACT_19183
CD28 dependent PI3K/Akt signaling (1) REACT_19358
CD28 dependent Vav1 pathway (3) REACT_19238
CDK-mediated phosphorylation and removal of Cdc6 (1) REACT_1221
CDO in myogenesis (2) REACT_21402
Cell-extracellular matrix interactions (1) REACT_20649
Cell redox homeostasis (5) REACT_121394
cGMP effects (1) REACT_23767
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (1) REACT_407
Cholesterol biosynthesis (8) REACT_9405
Chondroitin sulfate biosynthesis (2) REACT_120989
Citric acid cycle (TCA cycle) (11) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Clathrin derived vesicle budding (2) REACT_19187
Clearance of Nuclear Envelope Membranes from Chromatin (1) REACT_160251
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (8) REACT_163862
Coenzyme A biosynthesis (3) REACT_11218
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prometaphase Chromosomes (1) REACT_150260
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Constitutive PI3K/AKT Signaling in Cancer (1) REACT_147727
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (1) REACT_160254
Constitutive Signaling by NOTCH1 PEST Domain Mutants (1) REACT_160243
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (1) REACT_6867
COPII (Coat Protein 2) Mediated Vesicle Transport (2) REACT_12507
COPI Mediated Transport (2) REACT_11096
Creatine metabolism (3) REACT_813
CREB phosphorylation (1) REACT_12524
CREB phosphorylation through the activation of Adenylate Cyclase (3) REACT_20625
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
CREB phosphorylation through the activation of CaMKK (1) REACT_20661
CREB phosphorylation through the activation of Ras (2) REACT_20568
CRMPs in Sema3A signaling (1) REACT_19199
Cross-presentation of particulate exogenous antigens (phagosomes) (2) REACT_111174
c-src mediated regulation of Cx43 function and closure of gap junctions (1) REACT_11043
CTLA4 inhibitory signaling (1) REACT_19405
Cyclin A/B1 associated events during G2/M transition (1) REACT_1857
Cyclin A:Cdk2-associated events at S phase entry (1) REACT_9029
Cyclin B2 mediated events (1) REACT_2101
Cyclin D associated events in G1 (1) REACT_821
Cyclin E associated events during G1/S transition (1) REACT_1574
CYP2E1 reactions (2) REACT_13797
Cytosolic iron-sulfur cluster assembly (4) REACT_160176
Cytosolic tRNA aminoacylation (2) REACT_15306
DAG and IP3 signaling (1) REACT_111064
DAP12 signaling (3) REACT_147814
DARPP-32 events (2) REACT_15334
DCC mediated attractive signaling (3) REACT_22351
deactivation of the beta-catenin transactivating complex (1) REACT_200731
Defective B3GAT3 causes JDSSDHD (1) REACT_267659
Defective CHSY1 causes TPBS (1) REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1) REACT_267674
Defective EXT2 causes exostoses 2 (1) REACT_267654
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
Defective MMAB causes methylmalonic aciduria type cblB (1) REACT_169318
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC (1) REACT_169169
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (3) REACT_169439
Defective PAPSS2 causes SEMD-PA (1) REACT_267645
degradation of AXIN (1) REACT_200766
Degradation of beta-catenin by the destruction complex (1) REACT_11063
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (4) REACT_23964
Degradation of GLI1 by the proteasome (1) REACT_267605
Degradation of GLI2 by the proteasome (1) REACT_206597
Depolymerisation of the Nuclear Lamina (1) REACT_200828
Detoxification of Reactive Oxygen Species (4) REACT_172715
disassembly of the destruction complex and recruitment of AXIN to the membrane (1) REACT_200610
Disinhibition of SNARE formation (1) REACT_1178
DNA Damage/Telomere Stress Induced Senescence (1) REACT_169185
DNA methylation (1) REACT_267652
DNA replication initiation (3) REACT_2244
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Downregulation of ERBB2:ERBB3 signaling (1) REACT_115662
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Downstream signal transduction (3) REACT_17025
Downstream TCR signaling (2) REACT_12555
DSCAM interactions (2) REACT_25299
Effects of PIP2 hydrolysis (1) REACT_2202
EGFR downregulation (2) REACT_12484
EGFR interacts with phospholipase C-gamma (1) REACT_12478
EGFR Transactivation by Gastrin (2) REACT_121096
Eicosanoids (2) REACT_13645
Electron transport from NADPH to Ferredoxin (3) REACT_150128
Elevation of cytosolic Ca2+ levels (1) REACT_162
Endogenous sterols (2) REACT_13812
Endosomal Sorting Complex Required For Transport (ESCRT) (1) REACT_27258
eNOS activation (5) REACT_12477
Enzymatic degradation of dopamine by COMT (2) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHA-mediated growth cone collapse (3) REACT_228063
EPHB-mediated forward signaling (3) REACT_228085
EPH-ephrin mediated repulsion of cells (3) REACT_228189
EPH-Ephrin signaling (1) REACT_228170
Ephrin signaling (3) REACT_228226
ERK1 activation (1) REACT_1391
ERK2 activation (1) REACT_1183
ERK/MAPK targets (1) REACT_12599
ER-Phagosome pathway (1) REACT_111178
Establishment of Sister Chromatid Cohesion (1) REACT_150266
Estrogen biosynthesis (2) REACT_11037
Ethanol oxidation (5) REACT_34
Eukaryotic Translation Elongation (2) REACT_1477
Eukaryotic Translation Termination (2) REACT_1986
Factors involved in megakaryocyte development and platelet production (3) REACT_24970
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (2) REACT_22279
Fatty Acyl-CoA Biosynthesis (4) REACT_1319
Fc epsilon receptor (FCERI) signaling (1) REACT_163936
FCERI mediated Ca+2 mobilization (1) REACT_163834
FCERI mediated MAPK activation (3) REACT_163701
FCERI mediated NF-kB activation (2) REACT_163994
FCGR activation (1) REACT_160274
FGFR1b ligand binding and activation (1) REACT_9400
FGFR1c and Klotho ligand binding and activation (1) REACT_9484
FGFR1c ligand binding and activation (1) REACT_9515
FGFR2b ligand binding and activation (1) REACT_9416
FGFR2c ligand binding and activation (1) REACT_9413
FGFR3b ligand binding and activation (1) REACT_9508
FGFR3c ligand binding and activation (1) REACT_9510
FGFR4 ligand binding and activation (1) REACT_9452
FMO oxidises nucleophiles (3) REACT_13653
Folding of actin by CCT/TriC (1) REACT_17050
Formation of apoptosome (1) REACT_89
Formation of ATP by chemiosmotic coupling (1) REACT_6759
Formation of HIV-1 elongation complex containing HIV-1 Tat (1) REACT_6346
Formation of the active cofactor, UDP-glucuronate (5) REACT_6737
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
Formation of the ternary complex, and subsequently, the 43S complex (1) REACT_1079
Formation of tubulin folding intermediates by CCT/TriC (2) REACT_16956
Frs2-mediated activation (3) REACT_12076
FRS2-mediated cascade (3) REACT_21247
Fructose catabolism (1) REACT_1571
G0 and Early G1 (1) REACT_111214
G2/M DNA damage checkpoint (1) REACT_897
G2/M DNA replication checkpoint (1) REACT_1846
G2 Phase (1) REACT_1915
GAB1 signalosome (1) REACT_12578
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (1) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
Galactose catabolism (2) REACT_532
G alpha (12/13) signalling events (2) REACT_18407
G alpha (i) signalling events (11) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (6) REACT_19327
G alpha (z) signalling events (5) REACT_19333
Gap junction assembly (2) REACT_9509
Gastrin-CREB signalling pathway via PKC and MAPK (1) REACT_120966
G beta:gamma signalling through PI3Kgamma (1) REACT_19290
Generation of second messenger molecules (1) REACT_12623
GLI3 is processed to GLI3R by the proteasome (1) REACT_231645
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (5) REACT_18274
Glucagon signaling in metabolic regulation (2) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Glucocorticoid biosynthesis (4) REACT_11036
Gluconeogenesis (9) REACT_1520
Glucose transport (1) REACT_212
Glucuronidation (2) REACT_6784
Glutathione synthesis and recycling (2) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (4) REACT_169208
Glycolysis (7) REACT_1383
Glycosphingolipid metabolism (4) REACT_116105
Glyoxylate metabolism (5) REACT_16925
Golgi Associated Vesicle Biogenesis (3) REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (2) REACT_1100
G-protein activation (2) REACT_15457
GPVI-mediated activation cascade (3) REACT_1695
GRB2 events in EGFR signaling (2) REACT_12606
GRB2 events in ERBB2 signaling (2) REACT_115854
GRB2:SOS provides linkage to MAPK signaling for Integrins (1) REACT_15443
Growth hormone receptor signaling (1) REACT_111133
GTP hydrolysis and joining of the 60S ribosomal subunit (2) REACT_2085
HATs acetylate histones (1) REACT_172610
HCN channels (1) REACT_75862
HDL-mediated lipid transport (1) REACT_13621
HDMs demethylate histones (1) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Hedgehog 'off' state (5) REACT_267634
Heme biosynthesis (2) REACT_9465
Heme degradation (4) REACT_22297
Hh ligand biogenesis disease (1) REACT_228209
Histidine catabolism (1) REACT_1249
HIV Transcription Initiation (1) REACT_6332
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HSF1-dependent transactivation (1) REACT_200775
HS-GAG biosynthesis (3) REACT_121248
HS-GAG degradation (1) REACT_120752
HuR stabilizes mRNA (1) REACT_25218
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Hypusine synthesis from eIF5A-lysine (2) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (2) REACT_11082
Inactivation of Cdc42 and Rac (2) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (4) REACT_163919
Inhibition of TSC complex formation by PKB (1) REACT_6743
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Inositol transporters (1) REACT_19188
Integrin alphaIIb beta3 signaling (3) REACT_15523
Interaction between L1 and Ankyrins (1) REACT_22266
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (2) REACT_14805
Interferon alpha/beta signaling (1) REACT_25162
Interferon gamma signaling (1) REACT_25078
Interleukin-1 signaling (1) REACT_22442
Interleukin-2 signaling (1) REACT_27283
Interleukin-3, 5 and GM-CSF signaling (1) REACT_23837
Interleukin-6 signaling (1) REACT_27307
Interleukin-7 signaling (1) REACT_115529
Interleukin receptor SHC signaling (3) REACT_23891
Ion transport by P-type ATPases (1) REACT_25149
IRAK1 recruits IKK complex (1) REACT_24918
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (1) REACT_25354
IRAK2 mediated activation of TAK1 complex (1) REACT_25380
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (1) REACT_25018
IRE1alpha activates chaperones (1) REACT_18368
IRF3 mediated activation of type 1 IFN (1) REACT_118811
IRF3-mediated induction of type I IFN (1) REACT_163993
Iron uptake and transport (3) REACT_25060
IRS activation (1) REACT_570
IRS-related events triggered by IGF1R (1) REACT_150203
ISG15 antiviral mechanism (2) REACT_115831
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (1) REACT_21368
Keratan sulfate biosynthesis (3) REACT_121120
Kinesins (3) REACT_25201
KSRP destabilizes mRNA (1) REACT_25042
L13a-mediated translational silencing of Ceruloplasmin expression (1) REACT_79
L1CAM interactions (1) REACT_22205
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (6) REACT_121100
Loss of Nlp from mitotic centrosomes (1) REACT_15364
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (1) REACT_163743
Lysine catabolism (6) REACT_1298
Lysosome Vesicle Biogenesis (3) REACT_19287
MASTL Facilitates Mitotic Progression (1) REACT_150182
Meiotic recombination (1) REACT_27271
Meiotic synapsis (1) REACT_75792
MEK activation (1) REACT_962
Metabolism of folate and pterines (3) REACT_11167
Metabolism of nucleotides (6) REACT_1698
Metabolism of polyamines (2) REACT_14820
Metabolism of serotonin (3) REACT_15532
Methionine salvage pathway (1) REACT_75881
Methylation (9) REACT_6946
MHC class II antigen presentation (3) REACT_121399
MicroRNA (miRNA) biogenesis (2) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (2) REACT_11039
Mineralocorticoid biosynthesis (4) REACT_11047
Minus-strand DNA synthesis (4) REACT_9055
Miscellaneous substrates (3) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (5) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (5) REACT_228145
Mitochondrial ABC transporters (1) REACT_111108
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (4) REACT_160
Mitochondrial protein import (1) REACT_118595
Mitochondrial translation elongation (2) REACT_267677
Mitochondrial translation initiation (2) REACT_267680
Mitochondrial translation termination (2) REACT_267602
Mitochondrial tRNA aminoacylation (2) REACT_15302
Mitotic Prometaphase (2) REACT_682
Molybdenum cofactor biosynthesis (3) REACT_25073
MPS IIIC - Sanfilippo syndrome C (1) REACT_147860
mRNA 3'-end processing (1) REACT_1849
mRNA Capping (4) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3) REACT_20518
Mtb iron assimilation by chelation (2) REACT_121118
mTOR signalling (2) REACT_6838
MyD88 cascade initiated on plasma membrane (1) REACT_27215
MyD88 dependent cascade initiated on endosome (1) REACT_25222
MyD88:Mal cascade initiated on plasma membrane (1) REACT_6788
Na+/Cl- dependent neurotransmitter transporters (1) REACT_20506
NADPH regeneration (3) REACT_16904
NCAM1 interactions (1) REACT_18312
NCAM signaling for neurite out-growth (3) REACT_18334
Negative regulation of FGFR signaling (1) REACT_111184
Negative regulators of RIG-I/MDA5 signaling (1) REACT_25271
Nephrin interactions (1) REACT_23832
NEP/NS2 Interacts with the Cellular Export Machinery (2) REACT_6179
Netrin-1 signaling (1) REACT_22237
Netrin mediated repulsion signals (1) REACT_22384
Neurofascin interactions (1) REACT_22312
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (1) REACT_25039
NF-kB is activated and signals survival (1) REACT_13696
NGF-independant TRKA activation (1) REACT_11046
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (3) REACT_11213
Nicotinate metabolism (5) REACT_11088
Nitric oxide stimulates guanylate cyclase (4) REACT_23862
NOD1/2 Signaling Pathway (1) REACT_75776
Nonhomologous End-joining (NHEJ) (1) REACT_1022
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (2) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
NoRC negatively regulates rRNA expression (1) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (2) REACT_15418
NOSIP mediated eNOS trafficking (2) REACT_12510
NOSTRIN mediated eNOS trafficking (2) REACT_12541
NOTCH1 Intracellular Domain Regulates Transcription (1) REACT_118780
NRAGE signals death through JNK (3) REACT_13638
NRIF signals cell death from the nucleus (1) REACT_13643
Nuclear import of Rev protein (2) REACT_9395
Nuclear Pore Complex (NPC) Disassembly (1) REACT_163931
O-linked glycosylation of mucins (1) REACT_115606
Oncogene Induced Senescence (1) REACT_169325
Orc1 removal from chromatin (1) REACT_1156
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Orphan transporters (5) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
p130Cas linkage to MAPK signaling for integrins (2) REACT_15381
P2Y receptors (3) REACT_18289
p38MAPK events (3) REACT_12065
p53-Independent DNA Damage Response (1) REACT_2160
p75NTR recruits signalling complexes (1) REACT_13415
PAOs oxidise polyamines to amines (1) REACT_505
PCP/CE pathway (2) REACT_172581
PD-1 signaling (2) REACT_19324
PDE3B signalling (2) REACT_1451
PECAM1 interactions (1) REACT_12519
Pentose phosphate pathway (hexose monophosphate shunt) (2) REACT_1859
Peptide chain elongation (2) REACT_1404
PERK regulates gene expression (1) REACT_18277
Peroxisomal lipid metabolism (1) REACT_16957
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
Phospholipase C-mediated cascade (1) REACT_21310
phospho-PLA2 pathway (1) REACT_15466
Phosphorylation of CD3 and TCR zeta chains (1) REACT_12582
Phosphorylation of Emi1 (1) REACT_6875
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (1) REACT_308
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes (1) REACT_6362
PI3K/AKT activation (1) REACT_12464
PI-3K cascade (1) REACT_21270
PI3K Cascade (1) REACT_976
PI3K events in ERBB2 signaling (1) REACT_116008
PI3K events in ERBB4 signaling (1) REACT_115961
PIP3 activates AKT signaling (1) REACT_75829
PKA activation (3) REACT_15530
PKA activation in glucagon signalling (4) REACT_1946
PKA-mediated phosphorylation of CREB (1) REACT_15497
PKA-mediated phosphorylation of key metabolic factors (1) REACT_1525
Plasmalogen biosynthesis (3) REACT_1407
Platelet degranulation (4) REACT_318
Platelet homeostasis (1) REACT_23876
Platelet sensitization by LDL (1) REACT_23879
PLC beta mediated events (2) REACT_15426
PLCG1 events in ERBB2 signaling (1) REACT_115720
Polo-like kinase mediated events (1) REACT_1006
Polymerase switching (1) REACT_1792
Polymerase switching on the C-strand of the telomere (1) REACT_7987
Post-chaperonin tubulin folding pathway (1) REACT_16967
PRC2 methylates histones and DNA (1) REACT_200808
Pregnenolone biosynthesis (2) REACT_11038
Pre-NOTCH Processing in Golgi (2) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (2) REACT_118722
Processive synthesis on the C-strand of the telomere (3) REACT_8027
Prolactin receptor signaling (1) REACT_115697
Proline catabolism (3) REACT_1002
Propionyl-CoA catabolism (1) REACT_993
Prostacyclin signalling through prostacyclin receptor (2) REACT_23946
Proton-coupled monocarboxylate transport (2) REACT_20515
Purine catabolism (13) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (10) REACT_1776
Purine salvage (15) REACT_1923
Pyrimidine biosynthesis (10) REACT_21376
Pyrimidine catabolism (14) REACT_1023
Pyrimidine salvage reactions (10) REACT_655
Pyruvate metabolism (6) REACT_2071
RAF activation (2) REACT_2077
RAF phosphorylates MEK (2) REACT_614
Rap1 signalling (5) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (3) REACT_15510
Recycling of bile acids and salts (2) REACT_11042
Recycling of eIF2:GDP (2) REACT_1815
Recycling pathway of L1 (3) REACT_22365
Regulation by TREX1 (4) REACT_163652
Regulation of actin dynamics for phagocytic cup formation (3) REACT_160086
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of APC/C activators between G1/S and early anaphase (1) REACT_6837
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of HSF1-mediated heat shock response (2) REACT_200780
Regulation of insulin secretion (3) REACT_18325
Regulation of KIT signaling (1) REACT_111225
Regulation of PLK1 Activity at G2/M Transition (2) REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (5) REACT_12528
Regulation of Rheb GTPase activity by AMPK (3) REACT_21393
Regulation of signaling by CBL (1) REACT_23787
Regulation of thyroid hormone activity (2) REACT_15297
Release of eIF4E (2) REACT_6836
Removal of DNA patch containing abasic residue (1) REACT_2192
Removal of the Flap Intermediate (3) REACT_70
Removal of the Flap Intermediate from the C-strand (3) REACT_7999
Resolution of AP sites via the single-nucleotide replacement pathway (1) REACT_933
Resolution of Sister Chromatid Cohesion (4) REACT_150425
Respiratory electron transport (4) REACT_22393
Retinoid cycle disease events (3) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Retrograde neurotrophin signalling (2) REACT_12435
Reuptake of GABA (1) REACT_23910
Rev-mediated nuclear export of HIV RNA (2) REACT_6190
Rho GTPase cycle (2) REACT_11051
Ribosomal scanning and start codon recognition (2) REACT_931
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways (1) REACT_25359
RIP-mediated NFkB activation via ZBP1 (1) REACT_118563
RMTs methylate histone arginines (2) REACT_228108
RNA Polymerase II HIV Promoter Escape (1) REACT_6253
RNA Polymerase II Promoter Escape (1) REACT_2089
RNA Polymerase II Transcription Initiation (1) REACT_1851
RNA Polymerase II Transcription Initiation And Promoter Clearance (1) REACT_834
RNA Polymerase I Promoter Opening (1) REACT_2232
RNA Polymerase I Transcription Initiation (1) REACT_953
Role of Abl in Robo-Slit signaling (1) REACT_19230
Role of DCC in regulating apoptosis (1) REACT_22128
Role of LAT2/NTAL/LAB on calcium mobilization (1) REACT_163769
Role of phospholipids in phagocytosis (1) REACT_160158
Role of second messengers in netrin-1 signaling (1) REACT_22228
RSK activation (1) REACT_20510
S33 mutants of beta-catenin aren't phosphorylated (1) REACT_228159
S37 mutants of beta-catenin aren't phosphorylated (1) REACT_228251
S45 mutants of beta-catenin aren't phosphorylated (1) REACT_228137
S6K1-mediated signalling (2) REACT_6754
S6K1 signalling (1) REACT_6772
Scavenging by Class A Receptors (2) REACT_163699
SCF(Skp2)-mediated degradation of p27/p21 (1) REACT_9003
Sema3A PAK dependent Axon repulsion (2) REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (3) REACT_19279
Sema4D induced cell migration and growth-cone collapse (3) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (3) REACT_19266
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Separation of Sister Chromatids (3) REACT_150471
Serine biosynthesis (5) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
SHC1 events in EGFR signaling (3) REACT_12579
SHC1 events in ERBB2 signaling (3) REACT_115993
SHC1 events in ERBB4 signaling (3) REACT_116005
SHC activation (1) REACT_1661
SHC-mediated cascade (3) REACT_21374
SHC-mediated signalling (2) REACT_661
SHC-related events triggered by IGF1R (1) REACT_150139
Sialic acid metabolism (6) REACT_200874
Signal attenuation (1) REACT_508
Signaling by activated point mutants of FGFR1 (1) REACT_121153
Signaling by activated point mutants of FGFR3 (1) REACT_121337
Signaling by Activin (1) REACT_150238
Signaling by BMP (1) REACT_12034
Signaling by constitutively active EGFR (3) REACT_115852
Signaling by EGFR (1) REACT_9417
Signaling by ERBB2 (1) REACT_115755
Signaling by ERBB4 (1) REACT_115596
Signaling by FGFR (1) REACT_9470
Signaling by FGFR1 amplification mutants (1) REACT_120827
Signaling by FGFR1 fusion mutants (1) REACT_121141
Signaling by FGFR2 amplification mutants (1) REACT_121255
Signaling by FGFR4 mutants (1) REACT_121286
Signaling by FGFR mutants (3) REACT_121398
Signaling by Hippo (1) REACT_118607
Signaling by Insulin receptor (1) REACT_498
Signaling by Leptin (1) REACT_169118
Signaling by NODAL (1) REACT_111057
Signaling by PDGF (1) REACT_16888
Signaling by SCF-KIT (3) REACT_111040
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (1) REACT_150359
Signalling to ERK5 (1) REACT_12020
Signalling to p38 via RIT and RIN (2) REACT_12077
Signalling to RAS (2) REACT_12033
Signalling to STAT3 (1) REACT_12049
Signal regulatory protein (SIRP) family interactions (1) REACT_23916
Signal transduction by L1 (3) REACT_22272
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
SMAD2/3 MH2 Domain Mutants in Cancer (1) REACT_169165
SMAD2/3 Phosphorylation Motif Mutants in Cancer (1) REACT_169103
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (1) REACT_120734
Smooth Muscle Contraction (1) REACT_20558
SOS-mediated signalling (2) REACT_524
Sphingolipid de novo biosynthesis (5) REACT_115810
Spry regulation of FGF signaling (1) REACT_111080
Stabilization of p53 (1) REACT_309
STAT6-mediated induction of chemokines (1) REACT_163734
Sterols are 12-hydroxylated by CYP8B1 (2) REACT_13438
Stimulation of the cell death response by PAK-2p34 (1) REACT_13532
Stimuli-sensing channels (2) REACT_160189
STING mediated induction of host immune responses (3) REACT_147841
Striated Muscle Contraction (1) REACT_16969
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (7) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (2) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (24) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (4) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (2) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts (2) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (6) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (4) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (6) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2) REACT_150417
Synthesis of GDP-mannose (2) REACT_22423
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (2) REACT_150352
Synthesis of IP3 and IP4 in the cytosol (1) REACT_150312
Synthesis of IPs in the nucleus (1) REACT_150275
Synthesis of Ketone Bodies (3) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Lipoxins (LX) (4) REACT_150320
Synthesis of PA (3) REACT_120906
Synthesis of PC (6) REACT_121238
Synthesis of PE (5) REACT_120919
Synthesis of PG (4) REACT_121280
Synthesis of PI (4) REACT_121000
Synthesis of PIPs at the early endosome membrane (1) REACT_120756
Synthesis of PIPs at the ER membrane (1) REACT_121168
Synthesis of PIPs at the Golgi membrane (2) REACT_120836
Synthesis of PIPs at the late endosome membrane (1) REACT_120918
Synthesis of PIPs at the plasma membrane (1) REACT_121025
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (4) REACT_150149
Synthesis of pyrophosphates in the cytosol (1) REACT_150188
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (4) REACT_380
t(4;14) translocations of FGFR3 (1) REACT_121011
T41 mutants of beta-catenin aren't phosphorylated (1) REACT_228261
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (1) REACT_21281
Telomere C-strand synthesis initiation (3) REACT_7993
Telomere Extension By Telomerase (3) REACT_7974
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (6) REACT_111176
TGF-beta receptor signaling activates SMADs (1) REACT_120850
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (1) REACT_120726
TGFBR1 KD Mutants in Cancer (1) REACT_169263
TGFBR2 Kinase Domain Mutants in Cancer (1) REACT_169440
The activation of arylsulfatases (2) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (5) REACT_160156
The NLRP1 inflammasome (1) REACT_75927
The NLRP3 inflammasome (1) REACT_75808
The proton buffering model (3) REACT_6196
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (2) REACT_21384
Thromboxane signalling through TP receptor (2) REACT_20647
Thyroxine biosynthesis (3) REACT_15292
Tie2 Signaling (3) REACT_12621
Tolerance by Mtb to nitric oxide produced by macrophages (2) REACT_120983
TRAF3-dependent IRF activation pathway (1) REACT_25026
TRAF6 mediated induction of TAK1 complex (1) REACT_25351
TRAF6 mediated IRF7 activation (1) REACT_24938
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (1) REACT_25120
TRAF6 mediated NF-kB activation (1) REACT_24969
Trafficking and processing of endosomal TLR (1) REACT_118632
Trafficking of AMPA receptors (1) REACT_18307
Trafficking of dietary sterols (1) REACT_13781
Trafficking of GluR2-containing AMPA receptors (1) REACT_18422
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation by small RNAs (1) REACT_267668
Transcription of the HIV genome (1) REACT_6233
Transferrin endocytosis and recycling (1) REACT_25283
Translation initiation complex formation (1) REACT_1979
Translocation of GLUT4 to the plasma membrane (3) REACT_147867
Translocation of ZAP-70 to Immunological synapse (1) REACT_12596
Transport and synthesis of PAPS (2) REACT_6840
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9) REACT_1206
Transport of nucleotide sugars (4) REACT_22151
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (4) REACT_1190
Tristetraprolin (TTP) destabilizes mRNA (1) REACT_25064
TRKA activation by NGF (1) REACT_11060
Tryptophan catabolism (6) REACT_916
Ubiquinol biosynthesis (6) REACT_160111
Ubiquitin-dependent degradation of Cyclin D1 (1) REACT_4
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (1) REACT_1614
Uptake and function of anthrax toxins (3) REACT_228255
Urea cycle (5) REACT_847
Utilization of Ketone Bodies (3) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (5) REACT_24023
VEGFA-VEGFR2 Pathway (6) REACT_228166
VEGFR2 mediated cell proliferation (2) REACT_228024
VEGFR2 mediated vascular permeability (6) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (4) REACT_11070
Vitamin C (ascorbate) metabolism (3) REACT_11202
Vitamin D (calciferol) metabolism (2) REACT_13523
Vitamins (2) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (4) REACT_25012
WNT5A-dependent internalization of FZD4 (1) REACT_172599
WNT mediated activation of DVL (1) REACT_200668
Xenobiotics (2) REACT_13543
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