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ST000496 Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory statusList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (1)
REACT_1662
Abnormal metabolism in phenylketonuria (5)
REACT_121117
Acetylation (1)
REACT_6732
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (7)
REACT_238
Amino acid transport across the plasma membrane (17)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (16)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (16)
REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (4)
REACT_197
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Citric acid cycle (TCA cycle) (3)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (1)
REACT_2156
Collagen biosynthesis and modifying enzymes (1)
REACT_121139
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (3)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (16)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic tRNA aminoacylation (16)
REACT_15306
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (2)
REACT_23964
Digestion of dietary carbohydrate (1)
REACT_9472
Endosomal/Vacuolar pathway (16)
REACT_111168
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (16)
REACT_111178
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1)
REACT_19193
Fatty Acyl-CoA Biosynthesis (2)
REACT_1319
Free fatty acid receptors (1)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (3)
REACT_19231
G alpha (q) signalling events (4)
REACT_18283
Gluconeogenesis (4)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (17)
REACT_6960
Glycolysis (1)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
HDMs demethylate histones (1)
REACT_228178
Heme biosynthesis (1)
REACT_9465
Histidine catabolism (2)
REACT_1249
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPE (1)
REACT_120785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Inositol transporters (1)
REACT_19188
Interconversion of polyamines (2)
REACT_14805
Ligand-gated ion channel transport (1)
REACT_25387
Lysine catabolism (2)
REACT_1298
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (3)
REACT_14820
Methionine salvage pathway (1)
REACT_75881
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (16)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (15)
REACT_20506
Nicotinate metabolism (2)
REACT_11088
Organic anion transport (1)
REACT_22310
Organic anion transporters (1)
REACT_19372
Organic cation transport (2)
REACT_22357
Oxidative Stress Induced Senescence (1)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_120916
PAOs oxidise polyamines to amines (2)
REACT_505
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (16)
REACT_19328
Purine catabolism (3)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (2)
REACT_1923
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (3)
REACT_1023
Pyrimidine salvage reactions (1)
REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Reuptake of GABA (1)
REACT_23910
Scavenging by Class A Receptors (1)
REACT_163699
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
Sphingolipid de novo biosynthesis (2)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfur amino acid metabolism (2)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PE (2)
REACT_120919
Synthesis of PI (1)
REACT_121000
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1)
REACT_23824
TET1,2,3 and TDG demethylate DNA (1)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Thyroxine biosynthesis (2)
REACT_15292
Transport of fatty acids (1)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3)
REACT_1206
Tryptophan catabolism (4)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (3)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
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