ST000574 Effects of the Kinase Inhibitor Sorafenib on Serum Metabolism In Vivo using Non-targeted Metabolomics Analysis tissue).
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Activation of gene expression by SREBF (SREBP) (3) REACT_147904
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (1) REACT_228214
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (6) REACT_238
Amino acid transport across the plasma membrane (8) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (8) REACT_75842
Arachidonate production from DAG (2) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (3) REACT_111118
Branched-chain amino acid catabolism (2) REACT_197
Carnitine synthesis (2) REACT_2125
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (3) REACT_24941
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (1) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COX reactions (1) REACT_1396
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (8) REACT_111056
Cytosolic tRNA aminoacylation (8) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (1) REACT_23964
Digestion of dietary lipid (2) REACT_9518
Endosomal/Vacuolar pathway (8) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (8) REACT_111178
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
Free fatty acid receptors (3) REACT_21268
G alpha (i) signalling events (1) REACT_19231
G alpha (q) signalling events (3) REACT_18283
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (8) REACT_6960
Glycolysis (2) REACT_1383
Glyoxylate metabolism (3) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme biosynthesis (1) REACT_9465
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPE (1) REACT_120785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (1) REACT_14805
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (2) REACT_75881
Miscellaneous substrates (1) REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (8) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (8) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinate metabolism (1) REACT_11088
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (3) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Phenylalanine and tyrosine catabolism (4) REACT_1786
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (2) REACT_1407
PPARA activates gene expression (3) REACT_116145
Proline catabolism (1) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (8) REACT_19328
Purine catabolism (2) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (2) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (4) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (3) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
REV-ERBA represses gene expression (3) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (3) REACT_118659
Serine biosynthesis (2) REACT_115789
Sialic acid metabolism (1) REACT_200874
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PE (2) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Transcriptional activation of mitochondrial biogenesis (3) REACT_200608
Transcriptional regulation of white adipocyte differentiation (3) REACT_27161
Transport of fatty acids (4) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (4) REACT_1206
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (4) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (1) REACT_847
YAP1- and WWTR1 (TAZ)-stimulated gene expression (3) REACT_118713
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