ST000718 Targeted Metabolomics in Pediatric US Population Exposed to Low-Level Heavy Metals
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (3) REACT_121388
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Aflatoxin activation and detoxification (3) REACT_228214
alpha-linolenic acid (ALA) metabolism (4) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (10) REACT_238
Amino acid transport across the plasma membrane (18) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (2) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (2) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (2) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (2) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (2) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (2) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (2) REACT_2025
Beta-oxidation of pristanoyl-CoA (2) REACT_17017
Beta-oxidation of very long chain fatty acids (2) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (2) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (6) REACT_197
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Cell redox homeostasis (3) REACT_121394
Cholesterol biosynthesis (3) REACT_9405
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (3) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (4) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of particulate exogenous antigens (phagosomes) (1) REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (18) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic iron-sulfur cluster assembly (2) REACT_160176
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (19) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (2) REACT_23964
Detoxification of Reactive Oxygen Species (2) REACT_172715
Digestion of dietary lipid (1) REACT_9518
Eicosanoids (1) REACT_13645
Electron transport from NADPH to Ferredoxin (2) REACT_150128
Endogenous sterols (5) REACT_13812
Endosomal/Vacuolar pathway (18) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (18) REACT_111178
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (2) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
FMO oxidises nucleophiles (2) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
Free fatty acid receptors (2) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (1) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Glucocorticoid biosynthesis (5) REACT_11036
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (18) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycolysis (3) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Glyoxylate metabolism (4) REACT_16925
Heme biosynthesis (2) REACT_9465
Heme degradation (1) REACT_22297
Histidine catabolism (2) REACT_1249
HS-GAG degradation (1) REACT_120752
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
Iron uptake and transport (1) REACT_25060
ISG15 antiviral mechanism (1) REACT_115831
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (5) REACT_1298
Metabolism of folate and pterines (4) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (1) REACT_75881
Methylation (3) REACT_6946
Mineralocorticoid biosynthesis (4) REACT_11047
Miscellaneous substrates (1) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (2) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (19) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Mtb iron assimilation by chelation (1) REACT_121118
Na+/Cl- dependent neurotransmitter transporters (16) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinate metabolism (4) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
NOSIP mediated eNOS trafficking (1) REACT_12510
NOSTRIN mediated eNOS trafficking (1) REACT_12541
Organic anion transporters (1) REACT_19372
Orphan transporters (2) REACT_267716
PAOs oxidise polyamines to amines (1) REACT_505
PDE3B signalling (1) REACT_1451
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
Plasmalogen biosynthesis (3) REACT_1407
PPARA activates gene expression (1) REACT_116145
Pregnenolone biosynthesis (1) REACT_11038
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (4) REACT_1002
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (18) REACT_19328
Purine catabolism (4) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (3) REACT_1023
Pyruvate metabolism (2) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (2) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Regulation of thyroid hormone activity (1) REACT_15297
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Respiratory electron transport (3) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
REV-ERBA represses gene expression (1) REACT_118789
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sphingolipid de novo biosynthesis (3) REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (1) REACT_13438
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (4) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (5) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (3) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of Lipoxins (LX) (2) REACT_150320
Synthesis of PA (1) REACT_120906
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (3) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (4) REACT_160156
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Thyroxine biosynthesis (3) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (2) REACT_23892
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (6) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFA-VEGFR2 Pathway (2) REACT_228166
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamin D (calciferol) metabolism (1) REACT_13523
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
Xenobiotics (1) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
  logo