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ST000748 Placental cells (BeWo) phthalate exposure metabolomicsList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1)
REACT_850
Abacavir metabolism (3)
REACT_121388
ABCA transporters in lipid homeostasis (1)
REACT_111158
Abnormal metabolism in phenylketonuria (5)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of gene expression by SREBF (SREBP) (4)
REACT_147904
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
alpha-linolenic acid (ALA) metabolism (3)
REACT_121147
Alpha-oxidation of phytanate (2)
REACT_17003
Amino acid synthesis and interconversion (transamination) (6)
REACT_238
Amino acid transport across the plasma membrane (13)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Androgen biosynthesis (2)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (12)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (13)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (1)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1)
REACT_2025
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1)
REACT_22433
Biotin transport and metabolism (3)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (4)
REACT_111118
Branched-chain amino acid catabolism (3)
REACT_197
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (1)
REACT_2125
Catecholamine biosynthesis (3)
REACT_15551
Cell redox homeostasis (1)
REACT_121394
Cell surface interactions at the vascular wall (1)
REACT_12051
Cholesterol biosynthesis (2)
REACT_9405
Chondroitin sulfate biosynthesis (1)
REACT_120989
Chylomicron-mediated lipid transport (1)
REACT_6841
Circadian Clock (4)
REACT_24941
Citric acid cycle (TCA cycle) (4)
REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (3)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (4)
REACT_163862
Coenzyme A biosynthesis (1)
REACT_11218
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (3)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (3)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (7)
REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (12)
REACT_111056
Cytosolic sulfonation of small molecules (3)
REACT_6913
Cytosolic tRNA aminoacylation (13)
REACT_15306
DARPP-32 events (1)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Defective CHSY1 causes TPBS (1)
REACT_267682
Defective HLCS causes multiple carboxylase deficiency (1)
REACT_169312
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
degradation of AXIN (2)
REACT_200766
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (1)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Digestion of dietary lipid (5)
REACT_9518
DNA methylation (2)
REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (2)
REACT_121111
Endogenous sterols (3)
REACT_13812
Endosomal/Vacuolar pathway (12)
REACT_111168
eNOS activation (2)
REACT_12477
Enzymatic degradation of dopamine by COMT (2)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
ER-Phagosome pathway (12)
REACT_111178
Ethanol oxidation (2)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acids (2)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3)
REACT_19193
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
Formation of the active cofactor, UDP-glucuronate (1)
REACT_6737
formation of the beta-catenin:TCF transactivating complex (2)
REACT_200753
Free fatty acid receptors (7)
REACT_21268
Galactose catabolism (1)
REACT_532
G alpha (i) signalling events (2)
REACT_19231
G alpha (q) signalling events (7)
REACT_18283
G alpha (s) signalling events (3)
REACT_19327
Glucocorticoid biosynthesis (1)
REACT_11036
Gluconeogenesis (6)
REACT_1520
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (15)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycolysis (3)
REACT_1383
Glycosphingolipid metabolism (1)
REACT_116105
HDL-mediated lipid transport (1)
REACT_13621
Hedgehog ligand biogenesis (1)
REACT_228111
Heme degradation (1)
REACT_22297
Histidine catabolism (2)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1)
REACT_494
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hypusine synthesis from eIF5A-lysine (2)
REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Interconversion of polyamines (1)
REACT_14805
Iron uptake and transport (1)
REACT_25060
ISG15 antiviral mechanism (1)
REACT_115831
LDL-mediated lipid transport (1)
REACT_6934
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (3)
REACT_121100
Lysine catabolism (2)
REACT_1298
Meiotic recombination (2)
REACT_27271
Metabolism of folate and pterines (1)
REACT_11167
Metabolism of polyamines (4)
REACT_14820
Metabolism of serotonin (3)
REACT_15532
Methionine salvage pathway (2)
REACT_75881
Methylation (5)
REACT_6946
Mineralocorticoid biosynthesis (2)
REACT_11047
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1)
REACT_160
Mitochondrial tRNA aminoacylation (13)
REACT_15302
Molybdenum cofactor biosynthesis (3)
REACT_25073
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (13)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (3)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
NoRC negatively regulates rRNA expression (2)
REACT_200856
O-linked glycosylation of mucins (1)
REACT_115606
Organic anion transporters (1)
REACT_19372
Organic cation transport (4)
REACT_22357
Orphan transporters (9)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
PAOs oxidise polyamines to amines (1)
REACT_505
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
phospho-PLA2 pathway (1)
REACT_15466
Plasmalogen biosynthesis (1)
REACT_1407
Platelet degranulation (1)
REACT_318
Platelet sensitization by LDL (1)
REACT_23879
PPARA activates gene expression (4)
REACT_116145
PRC2 methylates histones and DNA (2)
REACT_200808
Pregnenolone biosynthesis (1)
REACT_11038
Proline catabolism (2)
REACT_1002
Proton-coupled monocarboxylate transport (1)
REACT_20515
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (12)
REACT_19328
Purine catabolism (5)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (3)
REACT_1923
Pyrimidine biosynthesis (2)
REACT_21376
Pyrimidine catabolism (3)
REACT_1023
Pyrimidine salvage reactions (3)
REACT_655
Pyruvate metabolism (1)
REACT_2071
Recycling of bile acids and salts (5)
REACT_11042
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1)
REACT_147797
Regulation of HSF1-mediated heat shock response (2)
REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (4)
REACT_19241
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Regulation of thyroid hormone activity (1)
REACT_15297
Removal of the Flap Intermediate (1)
REACT_70
Removal of the Flap Intermediate from the C-strand (1)
REACT_7999
Respiratory electron transport (2)
REACT_22393
Retinoid cycle disease events (2)
REACT_160130
Retinoid metabolism and transport (4)
REACT_24968
REV-ERBA represses gene expression (4)
REACT_118789
RMTs methylate histone arginines (2)
REACT_228108
Role of phospholipids in phagocytosis (2)
REACT_160158
RORA activates circadian gene expression (4)
REACT_118659
Scavenging by Class A Receptors (1)
REACT_163699
Scavenging by Class B Receptors (1)
REACT_163679
Scavenging by Class F Receptors (1)
REACT_163813
Scavenging by Class H Receptors (1)
REACT_164002
Scavenging of heme from plasma (1)
REACT_160163
Senescence-Associated Secretory Phenotype (SASP) (2)
REACT_169168
Serine biosynthesis (1)
REACT_115789
Serotonin and melatonin biosynthesis (4)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
SIRT1 negatively regulates rRNA Expression (4)
REACT_200827
snRNP Assembly (1)
REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sperm Motility And Taxes (1)
REACT_163875
Sphingolipid de novo biosynthesis (1)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (2)
REACT_116010
Sulfur amino acid metabolism (6)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (3)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (3)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (2)
REACT_150209
Synthesis of bile acids and bile salts (2)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (3)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7)
REACT_11041
Synthesis of dolichyl-phosphate mannose (1)
REACT_2032
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of GDP-mannose (1)
REACT_22423
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Ketone Bodies (2)
REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of Lipoxins (LX) (1)
REACT_150320
Synthesis of PA (2)
REACT_120906
Synthesis of PC (3)
REACT_121238
Synthesis of PE (1)
REACT_120919
Synthesis of PG (1)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3)
REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (7)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3)
REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
The activation of arylsulfatases (1)
REACT_121036
The canonical retinoid cycle in rods (twilight vision) (4)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (2)
REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1)
REACT_120983
Trafficking of dietary sterols (1)
REACT_13781
Transcriptional activation of mitochondrial biogenesis (4)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (4)
REACT_27161
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (6)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5)
REACT_1206
Transport of nucleotide sugars (2)
REACT_22151
Transport of organic anions (3)
REACT_23988
Transport of vitamins, nucleosides, and related molecules (1)
REACT_22285
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (5)
REACT_916
Ubiquinol biosynthesis (3)
REACT_160111
Urea cycle (4)
REACT_847
Utilization of Ketone Bodies (2)
REACT_59
VEGFR2 mediated vascular permeability (1)
REACT_228016
Vitamin B1 (thiamin) metabolism (2)
REACT_11117
Vitamin B2 (riboflavin) metabolism (2)
REACT_11070
Vitamin C (ascorbate) metabolism (2)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (2)
REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (4)
REACT_118713
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