ST000753 Comparison of the metabolome and lipidome of wild type and mdx/mTR mice
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (4) REACT_121388
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (2) REACT_163932
Adenylate cyclase activating pathway (1) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Amino acid synthesis and interconversion (transamination) (6) REACT_238
Amino acid transport across the plasma membrane (16) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (17) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (16) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
ARMS-mediated activation (1) REACT_12002
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (2) REACT_121408
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Axonal growth stimulation (1) REACT_13779
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (3) REACT_22433
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (2) REACT_197
Ca2+ pathway (2) REACT_172761
Catecholamine biosynthesis (1) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
cGMP effects (1) REACT_23767
Chondroitin sulfate biosynthesis (2) REACT_120989
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (1) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Class II GLUTs (1) REACT_19281
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Conjugation of phenylacetate with glutamine (1) REACT_6800
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
COX reactions (1) REACT_1396
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (16) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic tRNA aminoacylation (16) REACT_15306
DAP12 signaling (1) REACT_147814
DCC mediated attractive signaling (1) REACT_22351
Defective B3GAT3 causes JDSSDHD (1) REACT_267659
Defective CHSY1 causes TPBS (1) REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1) REACT_267674
Defective EXT2 causes exostoses 2 (1) REACT_267654
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (1) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary lipid (1) REACT_9518
Downstream signal transduction (1) REACT_17025
EGFR Transactivation by Gastrin (1) REACT_121096
Endosomal/Vacuolar pathway (16) REACT_111168
eNOS activation (3) REACT_12477
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (2) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (16) REACT_111178
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FCERI mediated MAPK activation (1) REACT_163701
Formation of the active cofactor, UDP-glucuronate (2) REACT_6737
Free fatty acid receptors (2) REACT_21268
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
GABA synthesis (1) REACT_24020
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (7) REACT_18283
G alpha (s) signalling events (1) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Gluconeogenesis (4) REACT_1520
Glucuronidation (2) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (17) REACT_6960
Glycogen synthesis (3) REACT_169208
Glycolysis (1) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Glyoxylate metabolism (1) REACT_16925
Golgi Associated Vesicle Biogenesis (1) REACT_19400
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
Hedgehog 'off' state (1) REACT_267634
Heme degradation (2) REACT_22297
Histidine catabolism (2) REACT_1249
HS-GAG biosynthesis (3) REACT_121248
HS-GAG degradation (1) REACT_120752
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interleukin receptor SHC signaling (1) REACT_23891
Keratan sulfate biosynthesis (2) REACT_121120
Kinesins (1) REACT_25201
Lysine catabolism (2) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (3) REACT_1698
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Miscellaneous substrates (1) REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (16) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (2) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
mTOR signalling (1) REACT_6838
Na+/Cl- dependent neurotransmitter transporters (15) REACT_20506
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Orphan transporters (2) REACT_267716
P2Y receptors (2) REACT_18289
p38MAPK events (1) REACT_12065
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (1) REACT_1407
Platelet degranulation (1) REACT_318
PLC beta mediated events (1) REACT_15426
PPARA activates gene expression (2) REACT_116145
Pre-NOTCH Processing in Golgi (1) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (2) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (16) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (6) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (1) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Retrograde neurotrophin signalling (1) REACT_12435
REV-ERBA represses gene expression (2) REACT_118789
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (2) REACT_118659
Scavenging by Class A Receptors (2) REACT_163699
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Sialic acid metabolism (1) REACT_200874
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (8) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The proton buffering model (1) REACT_6196
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (2) REACT_15292
Tie2 Signaling (1) REACT_12621
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (3) REACT_23892
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2) REACT_1206
Transport of nucleotide sugars (3) REACT_22151
Tryptophan catabolism (4) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (4) REACT_847
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin C (ascorbate) metabolism (1) REACT_11202
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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