ST000757 Tubuloglomerular feedback and salt-sensitive hypertension
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (2) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (1) REACT_163932
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (2) REACT_238
Amino acid transport across the plasma membrane (6) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (6) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (7) REACT_75842
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (1) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Catecholamine biosynthesis (2) REACT_15551
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (1) REACT_9405
Citric acid cycle (TCA cycle) (1) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (1) REACT_18319
Class II GLUTs (1) REACT_19281
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (2) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (6) REACT_111056
Cytosolic sulfonation of small molecules (2) REACT_6913
Cytosolic tRNA aminoacylation (7) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary lipid (2) REACT_9518
DNA methylation (1) REACT_267652
Endogenous sterols (3) REACT_13812
Endosomal/Vacuolar pathway (6) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
ER-Phagosome pathway (6) REACT_111178
Ethanol oxidation (1) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (2) REACT_21268
G alpha (q) signalling events (3) REACT_18283
G alpha (s) signalling events (4) REACT_19327
Gluconeogenesis (2) REACT_1520
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (8) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycolysis (1) REACT_1383
Heme biosynthesis (2) REACT_9465
Heme degradation (1) REACT_22297
Hydrolysis of LPC (1) REACT_120977
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Interconversion of polyamines (1) REACT_14805
Iron uptake and transport (1) REACT_25060
ISG15 antiviral mechanism (1) REACT_115831
Linoleic acid (LA) metabolism (1) REACT_121100
Meiotic recombination (1) REACT_27271
Metabolism of polyamines (2) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (1) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
Mitochondrial tRNA aminoacylation (7) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (6) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
PAOs oxidise polyamines to amines (1) REACT_505
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
PPARA activates gene expression (2) REACT_116145
PRC2 methylates histones and DNA (1) REACT_200808
Proline catabolism (1) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (6) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (5) REACT_655
Recycling of bile acids and salts (5) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Respiratory electron transport (1) REACT_22393
Retinoid metabolism and transport (1) REACT_24968
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
Scavenging by Class A Receptors (1) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serotonin and melatonin biosynthesis (2) REACT_15439
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sperm Motility And Taxes (1) REACT_163875
Stimuli-sensing channels (2) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (1) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (3) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (2) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (1) REACT_15292
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (2) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Transport of organic anions (2) REACT_23988
Tryptophan catabolism (3) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Urea cycle (3) REACT_847
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
  logo