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ST000757 Tubuloglomerular feedback and salt-sensitive hypertensionList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1)
REACT_850
Abacavir metabolism (1)
REACT_121388
Abnormal metabolism in phenylketonuria (2)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Activation of the phototransduction cascade (1)
REACT_163932
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
alpha-linolenic acid (ALA) metabolism (1)
REACT_121147
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (2)
REACT_238
Amino acid transport across the plasma membrane (6)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Androgen biosynthesis (1)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (6)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (7)
REACT_75842
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (1)
REACT_197
Ca2+ pathway (1)
REACT_172761
Cam-PDE 1 activation (1)
REACT_15408
Catecholamine biosynthesis (2)
REACT_15551
cGMP effects (1)
REACT_23767
Cholesterol biosynthesis (1)
REACT_9405
Citric acid cycle (TCA cycle) (1)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (3)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (1)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Coenzyme A biosynthesis (1)
REACT_11218
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (2)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (2)
REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (6)
REACT_111056
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (7)
REACT_15306
DARPP-32 events (1)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Digestion of dietary lipid (2)
REACT_9518
DNA methylation (1)
REACT_267652
Endogenous sterols (3)
REACT_13812
Endosomal/Vacuolar pathway (6)
REACT_111168
eNOS activation (2)
REACT_12477
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
ER-Phagosome pathway (6)
REACT_111178
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2)
REACT_19193
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
formation of the beta-catenin:TCF transactivating complex (1)
REACT_200753
Free fatty acid receptors (2)
REACT_21268
G alpha (q) signalling events (3)
REACT_18283
G alpha (s) signalling events (4)
REACT_19327
Gluconeogenesis (2)
REACT_1520
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (8)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycolysis (1)
REACT_1383
Heme biosynthesis (2)
REACT_9465
Heme degradation (1)
REACT_22297
Hydrolysis of LPC (1)
REACT_120977
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Interconversion of polyamines (1)
REACT_14805
Iron uptake and transport (1)
REACT_25060
ISG15 antiviral mechanism (1)
REACT_115831
Linoleic acid (LA) metabolism (1)
REACT_121100
Meiotic recombination (1)
REACT_27271
Metabolism of polyamines (2)
REACT_14820
Metabolism of serotonin (1)
REACT_15532
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Mineralocorticoid biosynthesis (1)
REACT_11047
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
Mitochondrial tRNA aminoacylation (7)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (6)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
Nicotinate metabolism (1)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
NoRC negatively regulates rRNA expression (1)
REACT_200856
Organic anion transport (1)
REACT_22310
Organic anion transporters (1)
REACT_19372
Organic cation transport (2)
REACT_22357
Orphan transporters (4)
REACT_267716
Oxidative Stress Induced Senescence (1)
REACT_169436
PAOs oxidise polyamines to amines (1)
REACT_505
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (3)
REACT_121256
Phenylalanine and tyrosine catabolism (3)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
PPARA activates gene expression (2)
REACT_116145
PRC2 methylates histones and DNA (1)
REACT_200808
Proline catabolism (1)
REACT_1002
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (6)
REACT_19328
Purine catabolism (7)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2)
REACT_1776
Purine salvage (5)
REACT_1923
Pyrimidine catabolism (5)
REACT_1023
Pyrimidine salvage reactions (5)
REACT_655
Recycling of bile acids and salts (5)
REACT_11042
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (2)
REACT_70
Removal of the Flap Intermediate from the C-strand (2)
REACT_7999
Respiratory electron transport (1)
REACT_22393
Retinoid metabolism and transport (1)
REACT_24968
RMTs methylate histone arginines (1)
REACT_228108
Role of phospholipids in phagocytosis (1)
REACT_160158
Scavenging by Class A Receptors (1)
REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1)
REACT_169168
Serotonin and melatonin biosynthesis (2)
REACT_15439
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Sperm Motility And Taxes (1)
REACT_163875
Stimuli-sensing channels (2)
REACT_160189
Sulfide oxidation to sulfate (2)
REACT_116010
Sulfur amino acid metabolism (1)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (3)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts (2)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PG (1)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1)
REACT_150149
Synthesis of PS (1)
REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2)
REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1)
REACT_160156
Thyroxine biosynthesis (1)
REACT_15292
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (2)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6)
REACT_1206
Transport of nucleotide sugars (1)
REACT_22151
Transport of organic anions (2)
REACT_23988
Tryptophan catabolism (3)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Urea cycle (3)
REACT_847
VEGFR2 mediated vascular permeability (2)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (2)
REACT_11070
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Vitamins (1)
REACT_13450
Vitamins B6 activation to pyridoxal phosphate (1)
REACT_25012
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