ST000899 Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
ABCA transporters in lipid homeostasis (1) REACT_111158
ABC-family proteins mediated transport (1) REACT_15480
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylation (2) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (4) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Advanced glycosylation endproduct receptor signaling (1) REACT_25195
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (9) REACT_238
Amino acid transport across the plasma membrane (24) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (20) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (20) REACT_75842
Arachidonate production from DAG (2) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of A2E, implicated in retinal degradation (1) REACT_160194
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (4) REACT_111118
Branched-chain amino acid catabolism (6) REACT_197
Carnitine synthesis (5) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Cell surface interactions at the vascular wall (1) REACT_12051
Cholesterol biosynthesis (1) REACT_9405
Chylomicron-mediated lipid transport (1) REACT_6841
Circadian Clock (4) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (7) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (7) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (3) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (3) REACT_6812
COX reactions (1) REACT_1396
Creatine metabolism (7) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (20) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (4) REACT_115589
Cytosolic sulfonation of small molecules (6) REACT_6913
Cytosolic tRNA aminoacylation (20) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (6) REACT_115654
Degradation of GABA (3) REACT_23964
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (1) REACT_163773
Digestion of dietary carbohydrate (2) REACT_9472
Digestion of dietary lipid (9) REACT_9518
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (4) REACT_13812
Endosomal/Vacuolar pathway (20) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (20) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Fatty acids (3) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (4) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FMO oxidises nucleophiles (1) REACT_13653
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (12) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (10) REACT_19231
G alpha (q) signalling events (9) REACT_18283
G alpha (s) signalling events (5) REACT_19327
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (5) REACT_1520
Glucuronidation (3) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (21) REACT_6960
Glycolysis (2) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (4) REACT_16925
HDL-mediated lipid transport (1) REACT_13621
HDMs demethylate histones (2) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Heme biosynthesis (1) REACT_9465
Heme degradation (2) REACT_22297
Histidine catabolism (3) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2) REACT_494
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (3) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
Iron uptake and transport (1) REACT_25060
LDL-mediated lipid transport (1) REACT_6934
Ligand-gated ion channel transport (2) REACT_25387
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (3) REACT_1298
Lysosphingolipid and LPA receptors (1) REACT_18365
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (3) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (3) REACT_6946
Miscellaneous substrates (1) REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (20) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (1) REACT_1470
Na+/Cl- dependent neurotransmitter transporters (22) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (5) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (6) REACT_22357
Orphan transporters (12) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (2) REACT_23826
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (7) REACT_1786
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (1) REACT_1407
Platelet degranulation (1) REACT_318
Platelet sensitization by LDL (1) REACT_23879
PPARA activates gene expression (6) REACT_116145
PRC2 methylates histones and DNA (1) REACT_200808
Pregnenolone biosynthesis (1) REACT_11038
Presynaptic function of Kainate receptors (1) REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (20) REACT_19328
Purine catabolism (6) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (9) REACT_1023
Pyrimidine salvage reactions (4) REACT_655
Pyruvate metabolism (2) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recycling of bile acids and salts (9) REACT_11042
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (4) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of thyroid hormone activity (1) REACT_15297
Retinoid cycle disease events (3) REACT_160130
Retinoid metabolism and transport (6) REACT_24968
Reuptake of GABA (2) REACT_23910
REV-ERBA represses gene expression (4) REACT_118789
RIP-mediated NFkB activation via ZBP1 (1) REACT_118563
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (2) REACT_160158
RORA activates circadian gene expression (4) REACT_118659
Scavenging by Class A Receptors (3) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Scavenging by Class H Receptors (2) REACT_164002
Scavenging of heme from plasma (1) REACT_160163
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serine biosynthesis (3) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (6) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (8) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (3) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (3) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (10) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of PA (2) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (3) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (13) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (5) REACT_23824
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (1) REACT_21281
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (5) REACT_160156
The retinoid cycle in cones (daylight vision) (3) REACT_160083
Thyroxine biosynthesis (3) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
TRAF6 mediated NF-kB activation (1) REACT_24969
Trafficking of dietary sterols (1) REACT_13781
Transcriptional activation of mitochondrial biogenesis (4) REACT_200608
Transcriptional regulation of white adipocyte differentiation (4) REACT_27161
Transport of fatty acids (7) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9) REACT_1206
Transport of organic anions (7) REACT_23988
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (8) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (7) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated cell proliferation (2) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (4) REACT_118713
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