ST000925 MuRF1-Related Metabolomic Changes in Stretched and Unloaded HL-1 Cells
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABCA transporters in lipid homeostasis (1) REACT_111158
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (5) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (9) REACT_238
Amino acid transport across the plasma membrane (19) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (5) REACT_197
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Cell surface interactions at the vascular wall (1) REACT_12051
Cholesterol biosynthesis (1) REACT_9405
Chylomicron-mediated lipid transport (1) REACT_6841
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (18) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (18) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (3) REACT_23964
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (2) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (18) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (18) REACT_111178
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (1) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (4) REACT_18283
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (18) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (4) REACT_16925
HDL-mediated lipid transport (1) REACT_13621
HDMs demethylate histones (2) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Heme biosynthesis (1) REACT_9465
Histidine catabolism (2) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2) REACT_494
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (2) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (2) REACT_14805
LDL-mediated lipid transport (1) REACT_6934
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (3) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (1) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (18) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (17) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transport (3) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
Passive transport by Aquaporins (2) REACT_23826
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (6) REACT_1786
Platelet sensitization by LDL (1) REACT_23879
Pregnenolone biosynthesis (1) REACT_11038
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (18) REACT_19328
Purine catabolism (3) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (2) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (2) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid metabolism and transport (1) REACT_24968
Reuptake of GABA (1) REACT_23910
Scavenging by Class A Receptors (1) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Scavenging by Class H Receptors (1) REACT_164002
Scavenging of heme from plasma (1) REACT_160163
Serine biosynthesis (3) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (3) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PE (1) REACT_120919
Synthesis of PG (2) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (2) REACT_15292
Trafficking of dietary sterols (1) REACT_13781
Transport of fatty acids (3) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3) REACT_1206
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (6) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (5) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
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