ST000969 Impact of thiamine metabolites and spent medium from Chlorella sorokiniana on metabolism in the green algae Auxenochlorella prototheciodes (part II)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (1) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (5) REACT_121117
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Adenylate cyclase activating pathway (1) REACT_15312
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (4) REACT_17003
Amino acid synthesis and interconversion (transamination) (10) REACT_238
Amino acid transport across the plasma membrane (17) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (16) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biotin transport and metabolism (3) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (4) REACT_197
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Cholesterol biosynthesis (2) REACT_9405
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (5) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (4) REACT_6933
Conjugation of phenylacetate with glutamine (3) REACT_6800
Conjugation of salicylate with glycine (3) REACT_6812
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (1) REACT_6867
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (16) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (18) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (2) REACT_23964
Digestion of dietary carbohydrate (3) REACT_9472
Digestion of dietary lipid (1) REACT_9518
Downstream TCR signaling (1) REACT_12555
Endosomal/Vacuolar pathway (16) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (16) REACT_111178
Ethanol oxidation (2) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
FCERI mediated NF-kB activation (2) REACT_163994
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
Free fatty acid receptors (4) REACT_21268
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (2) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Gluconeogenesis (7) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (17) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (4) REACT_1383
Glyoxylate metabolism (5) REACT_16925
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
HIV Transcription Initiation (1) REACT_6332
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (2) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (2) REACT_14805
ISG15 antiviral mechanism (2) REACT_115831
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (3) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Minus-strand DNA synthesis (1) REACT_9055
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2) REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (18) REACT_15302
Molybdenum cofactor biosynthesis (4) REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (16) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transport (2) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
Passive transport by Aquaporins (1) REACT_23826
PD-1 signaling (1) REACT_19324
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Plasmalogen biosynthesis (1) REACT_1407
Platelet degranulation (1) REACT_318
PPARA activates gene expression (2) REACT_116145
Proline catabolism (1) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (16) REACT_19328
Purine catabolism (2) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (3) REACT_1023
Pyruvate metabolism (2) REACT_2071
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (3) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of DNA patch containing abasic residue (1) REACT_2192
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Resolution of AP sites via the single-nucleotide replacement pathway (1) REACT_933
Respiratory electron transport (1) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
RNA Polymerase II HIV Promoter Escape (1) REACT_6253
RNA Polymerase II Promoter Escape (1) REACT_2089
RNA Polymerase II Transcription Initiation (1) REACT_1851
RORA activates circadian gene expression (2) REACT_118659
Serine biosynthesis (3) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (2) REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (2) REACT_160189
STING mediated induction of host immune responses (1) REACT_147841
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (3) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (2) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3) REACT_11041
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of IP2, IP, and Ins in the cytosol (3) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PE (3) REACT_120919
Synthesis of PG (2) REACT_121280
Synthesis of PI (2) REACT_121000
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (4) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (2) REACT_15292
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport and synthesis of PAPS (1) REACT_6840
Transport of fatty acids (7) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2) REACT_1206
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (5) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (7) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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