ST001048 Pediatric Inner-City Environmental Exposures at School and Home and Asthma Study
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (3) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (3) REACT_121117
Acetylation (2) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of the phototransduction cascade (1) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (16) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (13) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (13) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (2) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (2) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (5) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
cGMP effects (1) REACT_23767
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (5) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged pyrimidine (3) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (6) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (13) REACT_111056
CYP2E1 reactions (2) REACT_13797
Cysteine formation from homocysteine (4) REACT_115589
Cytosolic sulfonation of small molecules (3) REACT_6913
Cytosolic tRNA aminoacylation (13) REACT_15306
DARPP-32 events (1) REACT_15334
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (4) REACT_115654
Degradation of GABA (2) REACT_23964
Digestion of dietary carbohydrate (2) REACT_9472
Digestion of dietary lipid (4) REACT_9518
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (2) REACT_13812
Endosomal/Vacuolar pathway (13) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (13) REACT_111178
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FMO oxidises nucleophiles (1) REACT_13653
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (1) REACT_21268
G alpha (i) signalling events (7) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (5) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (3) REACT_1520
Glucuronidation (2) REACT_6784
Glutathione synthesis and recycling (14) REACT_6960
Glycogen synthesis (1) REACT_169208
Glycolysis (1) REACT_1383
Glyoxylate metabolism (1) REACT_16925
HCN channels (1) REACT_75862
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (2) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
Hydrolysis of LPC (1) REACT_120977
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Keratan sulfate biosynthesis (1) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (3) REACT_1298
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (3) REACT_75881
Methylation (5) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (13) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
mRNA Capping (1) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (15) REACT_20506
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (3) REACT_11213
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (2) REACT_22310
Organic anion transporters (1) REACT_19372
Organic cation transport (4) REACT_22357
Orphan transporters (5) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Plasmalogen biosynthesis (2) REACT_1407
PPARA activates gene expression (2) REACT_116145
PRC2 methylates histones and DNA (1) REACT_200808
Proline catabolism (1) REACT_1002
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (13) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (6) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (7) REACT_1023
Pyrimidine salvage reactions (5) REACT_655
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (6) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (1) REACT_24968
REV-ERBA represses gene expression (1) REACT_118789
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (6) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (6) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (2) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Transport of organic anions (2) REACT_23988
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
  logo