ST001091 Aspirin Metabolomics in Colorectal Cancer Chemoprevention (part 1 - Colon)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acetylcholine regulates insulin secretion (2) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (2) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Aflatoxin activation and detoxification (1) REACT_228214
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (13) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (12) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (11) REACT_75842
ARMS-mediated activation (1) REACT_12002
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Axonal growth stimulation (1) REACT_13779
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (2) REACT_22433
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (3) REACT_197
Ca2+ pathway (2) REACT_172761
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
Cell redox homeostasis (1) REACT_121394
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (2) REACT_9405
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Class II GLUTs (1) REACT_19281
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of phenylacetate with glutamine (1) REACT_6800
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (11) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (11) REACT_15306
DAP12 signaling (1) REACT_147814
DCC mediated attractive signaling (1) REACT_22351
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
Degradation of cysteine and homocysteine (4) REACT_115654
Degradation of GABA (2) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary lipid (2) REACT_9518
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Downstream signal transduction (1) REACT_17025
EGFR Transactivation by Gastrin (1) REACT_121096
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endosomal/Vacuolar pathway (11) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (2) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (2) REACT_15511
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (2) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (11) REACT_111178
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FCERI mediated MAPK activation (1) REACT_163701
FMO oxidises nucleophiles (1) REACT_13653
Free fatty acid receptors (3) REACT_21268
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
GABA synthesis (1) REACT_24020
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (5) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Gluconeogenesis (7) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (11) REACT_6960
Glycolysis (2) REACT_1383
Glyoxylate metabolism (3) REACT_16925
Golgi Associated Vesicle Biogenesis (1) REACT_19400
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
HDMs demethylate histones (1) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Highly calcium permeable nicotinic acetylcholine receptors (1) REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1) REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1) REACT_22223
Histidine catabolism (3) REACT_1249
HS-GAG degradation (1) REACT_120752
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (1) REACT_14805
Interleukin receptor SHC signaling (1) REACT_23891
Kinesins (1) REACT_25201
Lysine catabolism (4) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (3) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Miscellaneous substrates (2) REACT_13425
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (11) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (1) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
mTOR signalling (1) REACT_6838
Muscarinic acetylcholine receptors (1) REACT_16943
Na+/Cl- dependent neurotransmitter transporters (11) REACT_20506
NADPH regeneration (1) REACT_16904
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
Norepinephrine Neurotransmitter Release Cycle (2) REACT_15418
NOSIP mediated eNOS trafficking (1) REACT_12510
NOSTRIN mediated eNOS trafficking (1) REACT_12541
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
Organic anion transport (2) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
p38MAPK events (1) REACT_12065
PAOs oxidise polyamines to amines (1) REACT_505
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
Platelet degranulation (1) REACT_318
PLC beta mediated events (1) REACT_15426
Pre-NOTCH Processing in the Endoplasmic Reticulum (1) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (3) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (11) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (2) REACT_2071
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (3) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of pyruvate dehydrogenase (PDH) complex (3) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Respiratory electron transport (1) REACT_22393
Retrograde neurotrophin signalling (1) REACT_12435
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
Scavenging by Class A Receptors (1) REACT_163699
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Sialic acid metabolism (2) REACT_200874
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (6) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (4) REACT_11041
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of dolichyl-phosphate mannose (1) REACT_2032
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PC (2) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (4) REACT_24019
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The proton buffering model (1) REACT_6196
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (1) REACT_15292
Tie2 Signaling (1) REACT_12621
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (7) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Transport of organic anions (2) REACT_23988
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (5) REACT_847
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFA-VEGFR2 Pathway (2) REACT_228166
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
  logo