ST001122 Identification of urine metabolites in patients with interstitial cystitis using untargeted metabolomics (part II)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylation (2) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Amino acid synthesis and interconversion (transamination) (6) REACT_238
Amino acid transport across the plasma membrane (19) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (14) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (14) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (2) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (1) REACT_197
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (4) REACT_15551
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (1) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (6) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (8) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (14) REACT_111056
Cysteine formation from homocysteine (3) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (14) REACT_15306
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (2) REACT_23964
Digestion of dietary carbohydrate (2) REACT_9472
DNA methylation (2) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Eicosanoids (1) REACT_13645
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (14) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (2) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (14) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FMO oxidises nucleophiles (1) REACT_13653
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (3) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (15) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
Heme biosynthesis (2) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (4) REACT_1249
Hydrolysis of LPC (1) REACT_120977
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Ligand-gated ion channel transport (3) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Meiotic recombination (2) REACT_27271
Metabolism of Angiotensinogen to Angiotensins (1) REACT_147707
Metabolism of folate and pterines (2) REACT_11167
Metabolism of polyamines (3) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (14) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (2) REACT_1470
Na+/Cl- dependent neurotransmitter transporters (19) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (2) REACT_200856
Organic cation transport (5) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Platelet degranulation (1) REACT_318
PPARA activates gene expression (1) REACT_116145
PRC2 methylates histones and DNA (2) REACT_200808
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (1) REACT_1002
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (14) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (1) REACT_21376
Pyrimidine catabolism (6) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recycling of bile acids and salts (2) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of ornithine decarboxylase (ODC) (1) REACT_13565
Retinoid metabolism and transport (1) REACT_24968
Reuptake of GABA (2) REACT_23910
REV-ERBA represses gene expression (1) REACT_118789
RMTs methylate histone arginines (2) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (5) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (3) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (2) REACT_15292
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (7) REACT_1206
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (5) REACT_847
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (4) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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