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ST001131 Presentation of different serum metabolites in trauma patients versus healthy volunteers.List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (2)
REACT_121388
ABCA transporters in lipid homeostasis (1)
REACT_111158
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (5)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (3)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Acyl chain remodeling of DAG and TAG (1)
REACT_121122
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
Alpha-oxidation of phytanate (2)
REACT_17003
Amino acid synthesis and interconversion (transamination) (9)
REACT_238
Amino acid transport across the plasma membrane (21)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18)
REACT_75842
Arachidonate production from DAG (2)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1)
REACT_121408
Biotin transport and metabolism (1)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (3)
REACT_111118
Branched-chain amino acid catabolism (5)
REACT_197
Carnitine synthesis (3)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Cell surface interactions at the vascular wall (1)
REACT_12051
Cholesterol biosynthesis (2)
REACT_9405
Chondroitin sulfate biosynthesis (1)
REACT_120989
Chylomicron-mediated lipid transport (1)
REACT_6841
Circadian Clock (3)
REACT_24941
Citric acid cycle (TCA cycle) (5)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (3)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Collagen biosynthesis and modifying enzymes (2)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (2)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (2)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (3)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (18)
REACT_111056
CYP2E1 reactions (1)
REACT_13797
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (18)
REACT_15306
Defective B3GAT3 causes JDSSDHD (1)
REACT_267659
Defective CHSY1 causes TPBS (1)
REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1)
REACT_267674
Defective EXT2 causes exostoses 2 (1)
REACT_267654
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (3)
REACT_23964
Digestion of dietary carbohydrate (3)
REACT_9472
Digestion of dietary lipid (3)
REACT_9518
Endogenous sterols (1)
REACT_13812
Endosomal/Vacuolar pathway (18)
REACT_111168
eNOS activation (2)
REACT_12477
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (18)
REACT_111178
ER Quality Control Compartment (ERQC) (1)
REACT_25091
Fatty acids (2)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
Formation of the active cofactor, UDP-glucuronate (1)
REACT_6737
Free fatty acid receptors (5)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (5)
REACT_19231
G alpha (q) signalling events (6)
REACT_18283
Gluconeogenesis (6)
REACT_1520
Glucuronidation (2)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (19)
REACT_6960
Glycolysis (2)
REACT_1383
Glyoxylate metabolism (4)
REACT_16925
HDL-mediated lipid transport (1)
REACT_13621
HDMs demethylate histones (2)
REACT_228178
Hedgehog ligand biogenesis (1)
REACT_228111
Heme biosynthesis (1)
REACT_9465
Heme degradation (1)
REACT_22297
Histidine catabolism (2)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2)
REACT_494
HS-GAG biosynthesis (1)
REACT_121248
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (2)
REACT_120785
Hydroxycarboxylic acid-binding receptors (2)
REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Inositol transporters (1)
REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1)
REACT_25367
LDL-mediated lipid transport (1)
REACT_6934
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysine catabolism (3)
REACT_1298
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (1)
REACT_14820
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Miscellaneous substrates (1)
REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (18)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (18)
REACT_20506
Na+-dependent glucose transporters (1)
REACT_19165
NADPH regeneration (1)
REACT_16904
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
Organic anion transport (3)
REACT_22310
Organic anion transporters (4)
REACT_19372
Organic cation transport (1)
REACT_22357
Orphan transporters (4)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
Passive transport by Aquaporins (2)
REACT_23826
Phagosomal maturation (early endosomal stage) (1)
REACT_121256
Phenylalanine and tyrosine catabolism (6)
REACT_1786
phospho-PLA2 pathway (1)
REACT_15466
Plasmalogen biosynthesis (1)
REACT_1407
Platelet sensitization by LDL (1)
REACT_23879
PPARA activates gene expression (3)
REACT_116145
Pregnenolone biosynthesis (1)
REACT_11038
Presynaptic function of Kainate receptors (1)
REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1)
REACT_25396
Proline catabolism (2)
REACT_1002
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (18)
REACT_19328
Purine catabolism (3)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (2)
REACT_1923
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (4)
REACT_1023
Pyrimidine salvage reactions (1)
REACT_655
Pyruvate metabolism (2)
REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1)
REACT_25302
Recycling of bile acids and salts (2)
REACT_11042
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1)
REACT_147797
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (3)
REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (4)
REACT_24968
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (3)
REACT_118789
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (3)
REACT_118659
Scavenging by Class A Receptors (3)
REACT_163699
Scavenging by Class B Receptors (1)
REACT_163679
Scavenging by Class F Receptors (1)
REACT_163813
Scavenging by Class H Receptors (1)
REACT_164002
Scavenging of heme from plasma (1)
REACT_160163
Serine biosynthesis (3)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Sialic acid metabolism (1)
REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
Sphingolipid de novo biosynthesis (1)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (3)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts (1)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3)
REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PE (1)
REACT_120919
Synthesis of PG (2)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (5)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3)
REACT_23824
TET1,2,3 and TDG demethylate DNA (2)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (2)
REACT_15292
Trafficking of dietary sterols (1)
REACT_13781
Transcriptional activation of mitochondrial biogenesis (3)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (3)
REACT_27161
Transport of fatty acids (8)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3)
REACT_1206
Transport of nucleotide sugars (1)
REACT_22151
Triglyceride Biosynthesis (2)
REACT_1190
Tryptophan catabolism (6)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (6)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
VEGFR2 mediated vascular permeability (1)
REACT_228016
YAP1- and WWTR1 (TAZ)-stimulated gene expression (3)
REACT_118713
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