ST001189 1H NMR spectroscopy-based metabolic profiling of Ophiocordyceps sinensis and Cordyceps militaris of water-boiled and 50% ethanol-soaked extracts
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (2) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (3) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (20) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (17) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (17) REACT_75842
Arachidonate production from DAG (2) REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (4) REACT_197
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Citric acid cycle (TCA cycle) (1) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (17) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic tRNA aminoacylation (17) REACT_15306
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (2) REACT_23964
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (1) REACT_9518
Endosomal/Vacuolar pathway (17) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (17) REACT_111178
Ethanol oxidation (1) REACT_34
FMO oxidises nucleophiles (2) REACT_13653
Free fatty acid receptors (1) REACT_21268
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (5) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Gluconeogenesis (2) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (18) REACT_6960
Glyoxylate metabolism (2) REACT_16925
Heme biosynthesis (1) REACT_9465
Histidine catabolism (1) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Interconversion of polyamines (1) REACT_14805
Ligand-gated ion channel transport (2) REACT_25387
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (2) REACT_14820
Methylation (1) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (17) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (18) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (1) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (1) REACT_267716
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (17) REACT_19328
Purine catabolism (4) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Reuptake of GABA (2) REACT_23910
Role of phospholipids in phagocytosis (1) REACT_160158
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (2) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (3) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The fatty acid cycling model (1) REACT_6258
Thyroxine biosynthesis (2) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (4) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5) REACT_1206
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (4) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
VEGFR2 mediated vascular permeability (1) REACT_228016
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