ST001235 Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (5) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1) REACT_19180
Adrenoceptors (1) REACT_16927
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (23) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (4) REACT_197
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (3) REACT_15551
Cholesterol biosynthesis (1) REACT_9405
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (7) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic tRNA aminoacylation (19) REACT_15306
DARPP-32 events (1) REACT_15334
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (2) REACT_23964
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (19) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (19) REACT_111178
FMO oxidises nucleophiles (1) REACT_13653
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (8) REACT_19231
G alpha (q) signalling events (7) REACT_18283
G alpha (s) signalling events (5) REACT_19327
G alpha (z) signalling events (2) REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Gluconeogenesis (2) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (20) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HCN channels (1) REACT_75862
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (3) REACT_1249
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Interconversion of polyamines (2) REACT_14805
Ligand-gated ion channel transport (3) REACT_25387
Lysine catabolism (2) REACT_1298
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (4) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (3) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (19) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
mRNA Capping (1) REACT_1470
Na+/Cl- dependent neurotransmitter transporters (24) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transporters (1) REACT_19372
Organic cation transport (6) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
PAOs oxidise polyamines to amines (2) REACT_505
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Platelet degranulation (1) REACT_318
PRC2 methylates histones and DNA (1) REACT_200808
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (19) REACT_19328
Purine catabolism (3) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (4) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (6) REACT_1023
Pyrimidine salvage reactions (3) REACT_655
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of thyroid hormone activity (1) REACT_15297
Reuptake of GABA (3) REACT_23910
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (4) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (7) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (3) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (4) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9) REACT_1206
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (6) REACT_847
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
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