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ST001235 Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part IList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (1)
REACT_121388
Abnormal metabolism in phenylketonuria (5)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of G protein gated Potassium channels (1)
REACT_75831
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Adenosine P1 receptors (1)
REACT_18288
Adenylate cyclase activating pathway (1)
REACT_15312
Adrenaline,noradrenaline inhibits insulin secretion (1)
REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1)
REACT_19180
Adrenoceptors (1)
REACT_16927
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
Amino acid synthesis and interconversion (transamination) (7)
REACT_238
Amino acid transport across the plasma membrane (23)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (4)
REACT_197
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (3)
REACT_15551
Cholesterol biosynthesis (1)
REACT_9405
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (1)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2)
REACT_163862
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (7)
REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic tRNA aminoacylation (19)
REACT_15306
DARPP-32 events (1)
REACT_15334
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (2)
REACT_23964
DNA methylation (1)
REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Endosomal/Vacuolar pathway (19)
REACT_111168
eNOS activation (2)
REACT_12477
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (19)
REACT_111178
FMO oxidises nucleophiles (1)
REACT_13653
formation of the beta-catenin:TCF transactivating complex (1)
REACT_200753
GABA A receptor activation (1)
REACT_24987
GABA A (rho) receptor activation (1)
REACT_25168
GABA B receptor activation (1)
REACT_25031
GABA synthesis (2)
REACT_24020
GABA synthesis, release, reuptake and degradation (1)
REACT_23947
G alpha (12/13) signalling events (1)
REACT_18407
G alpha (i) signalling events (8)
REACT_19231
G alpha (q) signalling events (7)
REACT_18283
G alpha (s) signalling events (5)
REACT_19327
G alpha (z) signalling events (2)
REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1)
REACT_18274
Gluconeogenesis (2)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (20)
REACT_6960
Glycolysis (1)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
HCN channels (1)
REACT_75862
Hedgehog 'off' state (1)
REACT_267634
Heme biosynthesis (2)
REACT_9465
Histamine receptors (1)
REACT_16903
Histidine catabolism (3)
REACT_1249
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1)
REACT_25004
Interconversion of polyamines (2)
REACT_14805
Ligand-gated ion channel transport (3)
REACT_25387
Lysine catabolism (2)
REACT_1298
Meiotic recombination (1)
REACT_27271
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (4)
REACT_14820
Metabolism of serotonin (2)
REACT_15532
Methionine salvage pathway (3)
REACT_75881
Methylation (3)
REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (19)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
mRNA Capping (1)
REACT_1470
Na+/Cl- dependent neurotransmitter transporters (24)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
NoRC negatively regulates rRNA expression (1)
REACT_200856
Organic anion transporters (1)
REACT_19372
Organic cation transport (6)
REACT_22357
Orphan transporters (1)
REACT_267716
Oxidative Stress Induced Senescence (1)
REACT_169436
PAOs oxidise polyamines to amines (2)
REACT_505
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (4)
REACT_1786
PKA activation (1)
REACT_15530
PKA activation in glucagon signalling (1)
REACT_1946
Platelet degranulation (1)
REACT_318
PRC2 methylates histones and DNA (1)
REACT_200808
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (19)
REACT_19328
Purine catabolism (3)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (4)
REACT_1923
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (6)
REACT_1023
Pyrimidine salvage reactions (3)
REACT_655
Rap1 signalling (1)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (2)
REACT_11042
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of insulin secretion (1)
REACT_18325
Regulation of thyroid hormone activity (1)
REACT_15297
Reuptake of GABA (3)
REACT_23910
RMTs methylate histone arginines (1)
REACT_228108
Role of phospholipids in phagocytosis (1)
REACT_160158
Senescence-Associated Secretory Phenotype (SASP) (1)
REACT_169168
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (4)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
SIRT1 negatively regulates rRNA Expression (2)
REACT_200827
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfur amino acid metabolism (7)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PG (1)
REACT_121280
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Thyroxine biosynthesis (3)
REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (4)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9)
REACT_1206
Transport of organic anions (1)
REACT_23988
Tryptophan catabolism (7)
REACT_916
Ubiquinol biosynthesis (1)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Uptake and function of anthrax toxins (1)
REACT_228255
Urea cycle (6)
REACT_847
Vasopressin regulates renal water homeostasis via Aquaporins (1)
REACT_24023
VEGFR2 mediated vascular permeability (2)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
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