ST001240 Global Metabolic Analysis Trisomy 21 - Cohort 2
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Circadian Clock (2) REACT_24941
COX reactions (1) REACT_1396
Cysteine formation from homocysteine (1) REACT_115589
Digestion of dietary lipid (2) REACT_9518
Fatty acids (1) REACT_13814
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
Free fatty acid receptors (3) REACT_21268
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (1) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Gluconeogenesis (1) REACT_1520
Glutathione synthesis and recycling (1) REACT_6960
Glycogen synthesis (1) REACT_169208
Glycolysis (1) REACT_1383
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Linoleic acid (LA) metabolism (1) REACT_121100
Lysosphingolipid and LPA receptors (1) REACT_18365
Miscellaneous substrates (1) REACT_13425
Orphan transporters (5) REACT_267716
P2Y receptors (1) REACT_18289
phospho-PLA2 pathway (1) REACT_15466
PPARA activates gene expression (2) REACT_116145
Prostanoid ligand receptors (1) REACT_18425
Pyrimidine biosynthesis (1) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Recycling of bile acids and salts (3) REACT_11042
Regulation by TREX1 (1) REACT_163652
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Retinoid metabolism and transport (1) REACT_24968
REV-ERBA represses gene expression (2) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (2) REACT_118659
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3) REACT_24019
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Transport of organic anions (4) REACT_23988
VEGFR2 mediated cell proliferation (1) REACT_228024
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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