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ST001240 Global Metabolic Analysis Trisomy 21 - Cohort 2List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Activation of gene expression by SREBF (SREBP) (2)
REACT_147904
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2)
REACT_111118
Circadian Clock (2)
REACT_24941
COX reactions (1)
REACT_1396
Cysteine formation from homocysteine (1)
REACT_115589
Digestion of dietary lipid (2)
REACT_9518
Fatty acids (1)
REACT_13814
Formation of the active cofactor, UDP-glucuronate (1)
REACT_6737
Free fatty acid receptors (3)
REACT_21268
G alpha (i) signalling events (3)
REACT_19231
G alpha (q) signalling events (1)
REACT_18283
G alpha (s) signalling events (1)
REACT_19327
Gluconeogenesis (1)
REACT_1520
Glutathione synthesis and recycling (1)
REACT_6960
Glycogen synthesis (1)
REACT_169208
Glycolysis (1)
REACT_1383
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysosphingolipid and LPA receptors (1)
REACT_18365
Miscellaneous substrates (1)
REACT_13425
Orphan transporters (5)
REACT_267716
P2Y receptors (1)
REACT_18289
phospho-PLA2 pathway (1)
REACT_15466
PPARA activates gene expression (2)
REACT_116145
Prostanoid ligand receptors (1)
REACT_18425
Pyrimidine biosynthesis (1)
REACT_21376
Pyrimidine catabolism (2)
REACT_1023
Pyrimidine salvage reactions (2)
REACT_655
Recycling of bile acids and salts (3)
REACT_11042
Regulation by TREX1 (1)
REACT_163652
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2)
REACT_19241
Retinoid metabolism and transport (1)
REACT_24968
REV-ERBA represses gene expression (2)
REACT_118789
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (2)
REACT_118659
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfur amino acid metabolism (1)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3)
REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3)
REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3)
REACT_24019
The canonical retinoid cycle in rods (twilight vision) (1)
REACT_160156
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Transport of fatty acids (1)
REACT_23892
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1)
REACT_1206
Transport of organic anions (4)
REACT_23988
VEGFR2 mediated cell proliferation (1)
REACT_228024
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2)
REACT_118713
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