ST001275 Metabolomics-based profiling of the mode of action of Pathogen Box compounds in Trypanosoma brucei (part-II)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Activation of gene expression by SREBF (SREBP) (4) REACT_147904
Androgen biosynthesis (1) REACT_11059
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
BMAL1:CLOCK,NPAS2 activates circadian gene expression (4) REACT_111118
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (4) REACT_24941
COX reactions (1) REACT_1396
Cytosolic sulfonation of small molecules (3) REACT_6913
Digestion of dietary lipid (1) REACT_9518
Endogenous sterols (2) REACT_13812
eNOS activation (2) REACT_12477
Estrogen biosynthesis (1) REACT_11037
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (8) REACT_21268
G alpha (q) signalling events (2) REACT_18283
Glucocorticoid biosynthesis (1) REACT_11036
Glycosphingolipid metabolism (1) REACT_116105
Hedgehog ligand biogenesis (1) REACT_228111
Import of palmitoyl-CoA into the mitochondrial matrix (3) REACT_11082
Linoleic acid (LA) metabolism (1) REACT_121100
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (2) REACT_13425
Orphan transporters (4) REACT_267716
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (2) REACT_1407
PPARA activates gene expression (4) REACT_116145
Pregnenolone biosynthesis (1) REACT_11038
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (4) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
REV-ERBA represses gene expression (4) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (4) REACT_118659
Sphingolipid de novo biosynthesis (6) REACT_115810
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of very long-chain fatty acyl-CoAs (3) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (9) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Transcriptional activation of mitochondrial biogenesis (4) REACT_200608
Transcriptional regulation of white adipocyte differentiation (4) REACT_27161
Transport of fatty acids (5) REACT_23892
VEGFR2 mediated cell proliferation (1) REACT_228024
Vitamin D (calciferol) metabolism (2) REACT_13523
Vitamins (2) REACT_13450
YAP1- and WWTR1 (TAZ)-stimulated gene expression (4) REACT_118713
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