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ST001658 Control of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle MetabolitesList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (1)
REACT_121388
Abnormal metabolism in phenylketonuria (2)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of G protein gated Potassium channels (1)
REACT_75831
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (3)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
Amino acid synthesis and interconversion (transamination) (7)
REACT_238
Amino acid transport across the plasma membrane (15)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (11)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (11)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Branched-chain amino acid catabolism (1)
REACT_197
Carnitine synthesis (1)
REACT_2125
Citric acid cycle (TCA cycle) (1)
REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (2)
REACT_6812
Creatine metabolism (3)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (11)
REACT_111056
CYP2E1 reactions (1)
REACT_13797
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (11)
REACT_15306
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (1)
REACT_115654
Degradation of GABA (2)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Endosomal/Vacuolar pathway (11)
REACT_111168
eNOS activation (1)
REACT_12477
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (11)
REACT_111178
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
Fructose catabolism (1)
REACT_1571
GABA A receptor activation (1)
REACT_24987
GABA A (rho) receptor activation (1)
REACT_25168
GABA B receptor activation (1)
REACT_25031
GABA synthesis (2)
REACT_24020
GABA synthesis, release, reuptake and degradation (1)
REACT_23947
G alpha (i) signalling events (4)
REACT_19231
G alpha (q) signalling events (4)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
Gluconeogenesis (4)
REACT_1520
Glucuronidation (1)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (13)
REACT_6960
Glycolysis (2)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
Heme biosynthesis (2)
REACT_9465
Histamine receptors (1)
REACT_16903
Histidine catabolism (3)
REACT_1249
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1)
REACT_25004
Insulin effects increased synthesis of Xylulose-5-Phosphate (1)
REACT_939
Ligand-gated ion channel transport (2)
REACT_25387
Lysine catabolism (1)
REACT_1298
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (1)
REACT_14820
Methylation (1)
REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (11)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (13)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
Organic anion transporters (1)
REACT_19372
Organic cation transport (3)
REACT_22357
Orphan transporters (1)
REACT_267716
Pentose phosphate pathway (hexose monophosphate shunt) (1)
REACT_1859
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (3)
REACT_1786
PPARA activates gene expression (1)
REACT_116145
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (11)
REACT_19328
Purine catabolism (3)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (2)
REACT_1923
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (3)
REACT_1023
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Reuptake of GABA (3)
REACT_23910
Role of phospholipids in phagocytosis (1)
REACT_160158
Serine biosynthesis (2)
REACT_115789
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (5)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (3)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (1)
REACT_121238
Synthesis of PG (1)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Thyroxine biosynthesis (1)
REACT_15292
Transcriptional regulation of white adipocyte differentiation (1)
REACT_27161
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (4)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2)
REACT_1206
Tryptophan catabolism (2)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (5)
REACT_847
VEGFR2 mediated vascular permeability (1)
REACT_228016
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (1)
REACT_25012
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