ST001809 The Metabolic Benefits of Short Cycles of Very Low Caloric Intake are Dependent on Diet Composition in Middle-Aged Mice
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (5) REACT_121388
ABCA transporters in lipid homeostasis (1) REACT_111158
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (5) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (3) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Aflatoxin activation and detoxification (3) REACT_228214
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (4) REACT_17003
Amino acid synthesis and interconversion (transamination) (11) REACT_238
Amino acid transport across the plasma membrane (22) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (21) REACT_75842
Arachidonate production from DAG (2) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1) REACT_121408
Biotin transport and metabolism (3) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (3) REACT_111118
Branched-chain amino acid catabolism (5) REACT_197
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Cell surface interactions at the vascular wall (1) REACT_12051
Cholesterol biosynthesis (3) REACT_9405
Chondroitin sulfate biosynthesis (1) REACT_120989
Chylomicron-mediated lipid transport (1) REACT_6841
Circadian Clock (3) REACT_24941
Citric acid cycle (TCA cycle) (5) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (3) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (4) REACT_6933
Conjugation of phenylacetate with glutamine (3) REACT_6800
Conjugation of salicylate with glycine (3) REACT_6812
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (1) REACT_6867
COX reactions (1) REACT_1396
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19) REACT_111056
Cysteine formation from homocysteine (3) REACT_115589
Cytosolic sulfonation of small molecules (2) REACT_6913
Cytosolic tRNA aminoacylation (21) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective B3GAT3 causes JDSSDHD (1) REACT_267659
Defective CHSY1 causes TPBS (1) REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1) REACT_267674
Defective EXT2 causes exostoses 2 (1) REACT_267654
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (4) REACT_115654
Degradation of GABA (3) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary carbohydrate (2) REACT_9472
Digestion of dietary lipid (3) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Downstream TCR signaling (1) REACT_12555
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (19) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (19) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Ethanol oxidation (2) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
FCERI mediated NF-kB activation (2) REACT_163994
Formation of the active cofactor, UDP-glucuronate (2) REACT_6737
Free fatty acid receptors (5) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (8) REACT_19231
G alpha (q) signalling events (7) REACT_18283
G alpha (s) signalling events (3) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Gluconeogenesis (8) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (21) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (4) REACT_1383
Glyoxylate metabolism (5) REACT_16925
HDL-mediated lipid transport (1) REACT_13621
HDMs demethylate histones (2) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Heme degradation (1) REACT_22297
Highly calcium permeable nicotinic acetylcholine receptors (1) REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1) REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1) REACT_22223
Histidine catabolism (3) REACT_1249
HIV Transcription Initiation (1) REACT_6332
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2) REACT_494
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (2) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
ISG15 antiviral mechanism (2) REACT_115831
Keratan sulfate biosynthesis (1) REACT_121120
LDL-mediated lipid transport (1) REACT_6934
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Metabolism of nucleotides (2) REACT_1698
Metabolism of polyamines (3) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (3) REACT_6946
Minus-strand DNA synthesis (1) REACT_9055
Miscellaneous substrates (1) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2) REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (21) REACT_15302
Molybdenum cofactor biosynthesis (5) REACT_25073
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
Muscarinic acetylcholine receptors (1) REACT_16943
Na+/Cl- dependent neurotransmitter transporters (19) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (4) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transport (3) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (2) REACT_23826
PD-1 signaling (1) REACT_19324
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (7) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (3) REACT_150237
phospho-PLA2 pathway (1) REACT_15466
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Plasmalogen biosynthesis (1) REACT_1407
Platelet degranulation (1) REACT_318
Platelet sensitization by LDL (1) REACT_23879
PPARA activates gene expression (3) REACT_116145
Pregnenolone biosynthesis (1) REACT_11038
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (19) REACT_19328
Purine catabolism (10) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7) REACT_1776
Purine salvage (8) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (7) REACT_1023
Pyrimidine salvage reactions (4) REACT_655
Pyruvate metabolism (2) REACT_2071
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recycling of bile acids and salts (4) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (3) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of DNA patch containing abasic residue (1) REACT_2192
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Resolution of AP sites via the single-nucleotide replacement pathway (1) REACT_933
Respiratory electron transport (1) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (4) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (3) REACT_118789
RNA Polymerase II HIV Promoter Escape (1) REACT_6253
RNA Polymerase II Promoter Escape (1) REACT_2089
RNA Polymerase II Transcription Initiation (1) REACT_1851
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (3) REACT_118659
Scavenging by Class A Receptors (4) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Scavenging by Class H Receptors (1) REACT_164002
Scavenging of heme from plasma (1) REACT_160163
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (3) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (3) REACT_160189
STING mediated induction of host immune responses (1) REACT_147841
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (6) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (2) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (5) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (3) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (3) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (4) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (3) REACT_121238
Synthesis of PE (4) REACT_120919
Synthesis of PG (4) REACT_121280
Synthesis of PI (3) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (4) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (2) REACT_15292
Trafficking of dietary sterols (1) REACT_13781
Transcriptional activation of mitochondrial biogenesis (3) REACT_200608
Transcriptional regulation of white adipocyte differentiation (3) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport and synthesis of PAPS (1) REACT_6840
Transport of fatty acids (7) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (8) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (6) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (8) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin C (ascorbate) metabolism (2) REACT_11202
YAP1- and WWTR1 (TAZ)-stimulated gene expression (3) REACT_118713
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