ST001835 Use of Integrated Metabolomics, Transcriptomics, and Signal Protein Profile to Characterize the Effector Function and Associated Metabotype of Polarized Macrophage Phenotypes
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (8) REACT_121388
ABCA transporters in lipid homeostasis (1) REACT_111158
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (9) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (2) REACT_163932
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (2) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (3) REACT_14800
alpha-linolenic acid (ALA) metabolism (5) REACT_121147
Alpha-oxidation of phytanate (5) REACT_17003
Amino acid synthesis and interconversion (transamination) (13) REACT_238
Amino acid transport across the plasma membrane (24) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (21) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (21) REACT_75842
Arachidonate production from DAG (1) REACT_19308
ARMS-mediated activation (1) REACT_12002
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (3) REACT_121408
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Axonal growth stimulation (1) REACT_13779
Beta oxidation of butanoyl-CoA to acetyl-CoA (3) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (3) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (3) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (3) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (3) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (3) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (3) REACT_2025
Beta-oxidation of pristanoyl-CoA (3) REACT_17017
Beta-oxidation of very long chain fatty acids (3) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (3) REACT_22433
Biotin transport and metabolism (3) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (9) REACT_197
Ca2+ pathway (2) REACT_172761
Cam-PDE 1 activation (2) REACT_15408
Carnitine synthesis (7) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
Cell redox homeostasis (3) REACT_121394
Cell surface interactions at the vascular wall (1) REACT_12051
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (4) REACT_9405
Chondroitin sulfate biosynthesis (2) REACT_120989
Chylomicron-mediated lipid transport (1) REACT_6841
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (8) REACT_1785
Class A/1 (Rhodopsin-like receptors) (4) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Class II GLUTs (1) REACT_19281
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (5) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Collagen biosynthesis and modifying enzymes (4) REACT_121139
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (4) REACT_6933
Conjugation of phenylacetate with glutamine (3) REACT_6800
Conjugation of salicylate with glycine (4) REACT_6812
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
Creatine metabolism (8) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (20) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic sulfonation of small molecules (7) REACT_6913
Cytosolic tRNA aminoacylation (21) REACT_15306
DAP12 signaling (1) REACT_147814
DARPP-32 events (2) REACT_15334
DCC mediated attractive signaling (1) REACT_22351
Deadenylation of mRNA (1) REACT_20514
Defective B3GAT3 causes JDSSDHD (1) REACT_267659
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (1) REACT_267635
Defective B4GALT7 causes EDS, progeroid type (1) REACT_267711
Defective CHSY1 causes TPBS (1) REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1) REACT_267674
Defective EXT2 causes exostoses 2 (1) REACT_267654
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (2) REACT_200766
Degradation of cysteine and homocysteine (6) REACT_115654
Degradation of GABA (5) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (4) REACT_9518
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (2) REACT_121111
Downstream signal transduction (1) REACT_17025
EGFR Transactivation by Gastrin (1) REACT_121096
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endogenous sterols (2) REACT_13812
Endosomal/Vacuolar pathway (20) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (2) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (3) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (20) REACT_111178
Ethanol oxidation (3) REACT_34
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (2) REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (2) REACT_22279
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FCERI mediated MAPK activation (1) REACT_163701
FCERI mediated NF-kB activation (1) REACT_163994
FMO oxidises nucleophiles (2) REACT_13653
Formation of the active cofactor, UDP-glucuronate (4) REACT_6737
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (3) REACT_21268
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
GABA synthesis (1) REACT_24020
Galactose catabolism (2) REACT_532
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (11) REACT_19231
G alpha (q) signalling events (8) REACT_18283
G alpha (s) signalling events (6) REACT_19327
G alpha (z) signalling events (2) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (2) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (11) REACT_1520
Glucuronidation (5) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (21) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (3) REACT_169208
Glycolysis (7) REACT_1383
Glycosphingolipid metabolism (5) REACT_116105
Glyoxylate metabolism (4) REACT_16925
Golgi Associated Vesicle Biogenesis (1) REACT_19400
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
HCN channels (1) REACT_75862
HDL-mediated lipid transport (1) REACT_13621
HDMs demethylate histones (2) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Hedgehog 'off' state (2) REACT_267634
Heme biosynthesis (2) REACT_9465
Heme degradation (3) REACT_22297
Histidine catabolism (3) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2) REACT_494
HS-GAG biosynthesis (3) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (3) REACT_163785
Hypusine synthesis from eIF5A-lysine (3) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (6) REACT_14805
Interleukin receptor SHC signaling (1) REACT_23891
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (4) REACT_121120
Kinesins (1) REACT_25201
LDL-mediated lipid transport (1) REACT_6934
Ligand-gated ion channel transport (2) REACT_25387
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (7) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (4) REACT_11167
Metabolism of nucleotides (5) REACT_1698
Metabolism of polyamines (5) REACT_14820
Metabolism of serotonin (4) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (5) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Mineralocorticoid biosynthesis (2) REACT_11047
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (3) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (21) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (4) REACT_25073
mRNA Capping (3) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4) REACT_20518
mTOR signalling (1) REACT_6838
Na+/Cl- dependent neurotransmitter transporters (22) REACT_20506
NADPH regeneration (1) REACT_16904
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
N-Glycan antennae elongation (1) REACT_25085
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (4) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
NoRC negatively regulates rRNA expression (1) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
NOSIP mediated eNOS trafficking (1) REACT_12510
NOSTRIN mediated eNOS trafficking (1) REACT_12541
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
O-linked glycosylation of mucins (2) REACT_115606
Organic anion transport (4) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (7) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
P2Y receptors (2) REACT_18289
p38MAPK events (1) REACT_12065
PAOs oxidise polyamines to amines (6) REACT_505
Passive transport by Aquaporins (2) REACT_23826
PDE3B signalling (2) REACT_1451
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (9) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Plasmalogen biosynthesis (2) REACT_1407
Platelet degranulation (2) REACT_318
Platelet sensitization by LDL (1) REACT_23879
PLC beta mediated events (1) REACT_15426
PPARA activates gene expression (2) REACT_116145
PRC2 methylates histones and DNA (1) REACT_200808
Pregnenolone biosynthesis (1) REACT_11038
Pre-NOTCH Processing in Golgi (3) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (2) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (5) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (20) REACT_19328
Purine catabolism (11) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (12) REACT_1776
Purine salvage (9) REACT_1923
Pyrimidine biosynthesis (5) REACT_21376
Pyrimidine catabolism (12) REACT_1023
Pyrimidine salvage reactions (5) REACT_655
Pyruvate metabolism (5) REACT_2071
Rap1 signalling (2) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (3) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (5) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of HSF1-mediated heat shock response (2) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (3) REACT_12528
Regulation of Rheb GTPase activity by AMPK (2) REACT_21393
Removal of the Flap Intermediate (4) REACT_70
Removal of the Flap Intermediate from the C-strand (4) REACT_7999
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Respiratory electron transport (4) REACT_22393
Retinoid cycle disease events (2) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Retrograde neurotrophin signalling (1) REACT_12435
Reuptake of GABA (2) REACT_23910
REV-ERBA represses gene expression (1) REACT_118789
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (3) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Scavenging by Class H Receptors (1) REACT_164002
Scavenging of heme from plasma (1) REACT_160163
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (6) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Sialic acid metabolism (4) REACT_200874
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (6) REACT_115810
Stimuli-sensing channels (2) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (10) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (12) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of bile acids and bile salts (2) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (4) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (4) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (9) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (2) REACT_22230
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (2) REACT_150352
Synthesis of Ketone Bodies (2) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Lipoxins (LX) (2) REACT_150320
Synthesis of PA (5) REACT_120906
Synthesis of PC (4) REACT_121238
Synthesis of PE (4) REACT_120919
Synthesis of PG (5) REACT_121280
Synthesis of PI (3) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (4) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The activation of arylsulfatases (2) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The proton buffering model (1) REACT_6196
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (2) REACT_15292
Tie2 Signaling (1) REACT_12621
Tolerance by Mtb to nitric oxide produced by macrophages (2) REACT_120983
Trafficking of dietary sterols (1) REACT_13781
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Translocation of GLUT4 to the plasma membrane (2) REACT_147867
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (11) REACT_1206
Transport of nucleotide sugars (5) REACT_22151
Transport of organic anions (1) REACT_23988
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (4) REACT_1190
Tryptophan catabolism (10) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (9) REACT_847
Utilization of Ketone Bodies (3) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (2) REACT_24023
VEGFA-VEGFR2 Pathway (2) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (3) REACT_228016
Vitamin B1 (thiamin) metabolism (2) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin C (ascorbate) metabolism (3) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (5) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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