ST001844 Identification of unique metabolite networks between Latino and Caucasian patients with nonalcoholic fatty liver disease (NAFLD) (part III)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (5) REACT_121388
Abnormal metabolism in phenylketonuria (3) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2) REACT_15309
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (1) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (3) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (6) REACT_238
Amino acid transport across the plasma membrane (13) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (10) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (2) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (2) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (2) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (2) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (2) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (2) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (2) REACT_2025
Beta-oxidation of pristanoyl-CoA (2) REACT_17017
Beta-oxidation of very long chain fatty acids (2) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (4) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (3) REACT_15551
Cell redox homeostasis (2) REACT_121394
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (2) REACT_9405
Citric acid cycle (TCA cycle) (2) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (5) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (3) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (5) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (9) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cytosolic iron-sulfur cluster assembly (2) REACT_160176
Cytosolic sulfonation of small molecules (3) REACT_6913
Cytosolic tRNA aminoacylation (10) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (3) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (2) REACT_23964
Detoxification of Reactive Oxygen Species (2) REACT_172715
Digestion of dietary lipid (2) REACT_9518
DNA methylation (2) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endogenous sterols (2) REACT_13812
Endosomal/Vacuolar pathway (9) REACT_111168
eNOS activation (4) REACT_12477
Enzymatic degradation of dopamine by COMT (3) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (2) REACT_15511
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (9) REACT_111178
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (2) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
FCERI mediated NF-kB activation (1) REACT_163994
FMO oxidises nucleophiles (2) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
GABA synthesis (1) REACT_24020
Galactose catabolism (1) REACT_532
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (3) REACT_19327
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (3) REACT_1520
Glucuronidation (2) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (11) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (2) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Glyoxylate metabolism (2) REACT_16925
Heme biosynthesis (1) REACT_9465
Heme degradation (1) REACT_22297
Highly calcium permeable nicotinic acetylcholine receptors (1) REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1) REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1) REACT_22223
Histamine receptors (1) REACT_16903
Histidine catabolism (5) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
Hydrolysis of LPC (1) REACT_120977
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
Iron uptake and transport (1) REACT_25060
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (1) REACT_121120
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (4) REACT_1298
Lysosphingolipid and LPA receptors (1) REACT_18365
Meiotic recombination (2) REACT_27271
Metabolism of folate and pterines (1) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (2) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (6) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (2) REACT_160
Mitochondrial tRNA aminoacylation (10) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
mRNA Capping (3) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3) REACT_20518
Muscarinic acetylcholine receptors (1) REACT_16943
Na+/Cl- dependent neurotransmitter transporters (12) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (2) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinate metabolism (4) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (2) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
NOSIP mediated eNOS trafficking (2) REACT_12510
NOSTRIN mediated eNOS trafficking (2) REACT_12541
Organic anion transporters (1) REACT_19372
Organic cation transport (5) REACT_22357
Orphan transporters (3) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
PAOs oxidise polyamines to amines (1) REACT_505
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (4) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
Plasmalogen biosynthesis (1) REACT_1407
PRC2 methylates histones and DNA (2) REACT_200808
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (4) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (9) REACT_19328
Purine catabolism (10) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (6) REACT_1776
Purine salvage (9) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (2) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (4) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (3) REACT_70
Removal of the Flap Intermediate from the C-strand (3) REACT_7999
Respiratory electron transport (4) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Reuptake of GABA (2) REACT_23910
RMTs methylate histone arginines (2) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
Scavenging by Class A Receptors (2) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
snRNP Assembly (1) REACT_11066
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (8) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (7) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (2) REACT_120906
Synthesis of PC (4) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (2) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (7) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Transport of organic anions (2) REACT_23988
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (3) REACT_916
Ubiquinol biosynthesis (4) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (4) REACT_228016
Vitamin B1 (thiamin) metabolism (2) REACT_11117
Vitamin B2 (riboflavin) metabolism (3) REACT_11070
Vitamin C (ascorbate) metabolism (3) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (2) REACT_25012
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