ST001855 The metabolomic resetting effect of FG4592 in AKI to CKD transition-day 21 (Part 1)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (4) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (2) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (2) REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1) REACT_19180
Adrenoceptors (1) REACT_16927
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (3) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (3) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (13) REACT_238
Amino acid transport across the plasma membrane (24) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19) REACT_75842
ARMS-mediated activation (1) REACT_12002
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (2) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (5) REACT_197
Ca2+ pathway (2) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (4) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
CDO in myogenesis (1) REACT_21402
cGMP effects (1) REACT_23767
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (5) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Class II GLUTs (1) REACT_19281
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (3) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3) REACT_163862
Coenzyme A biosynthesis (3) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
COX reactions (2) REACT_1396
Creatine metabolism (5) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
CREB phosphorylation through the activation of Ras (1) REACT_20568
Cross-presentation of soluble exogenous antigens (endosomes) (18) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (4) REACT_115589
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic sulfonation of small molecules (4) REACT_6913
Cytosolic tRNA aminoacylation (19) REACT_15306
DAP12 signaling (1) REACT_147814
DARPP-32 events (1) REACT_15334
DCC mediated attractive signaling (1) REACT_22351
Deadenylation of mRNA (1) REACT_20514
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (6) REACT_115654
Degradation of GABA (5) REACT_23964
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (2) REACT_9518
DNA methylation (1) REACT_267652
DNA replication initiation (1) REACT_2244
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Downstream signal transduction (1) REACT_17025
DSCAM interactions (1) REACT_25299
EGFR downregulation (1) REACT_12484
EGFR Transactivation by Gastrin (1) REACT_121096
Eicosanoid ligand-binding receptors (1) REACT_18352
Eicosanoids (2) REACT_13645
Endogenous sterols (2) REACT_13812
Endosomal/Vacuolar pathway (18) REACT_111168
eNOS activation (4) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (2) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (18) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Ethanol oxidation (1) REACT_34
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (2) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (4) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated MAPK activation (1) REACT_163701
FCERI mediated NF-kB activation (1) REACT_163994
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Formation of the ternary complex, and subsequently, the 43S complex (1) REACT_1079
Formation of tubulin folding intermediates by CCT/TriC (1) REACT_16956
Free fatty acid receptors (5) REACT_21268
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (3) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (12/13) signalling events (2) REACT_18407
G alpha (i) signalling events (10) REACT_19231
G alpha (q) signalling events (10) REACT_18283
G alpha (s) signalling events (9) REACT_19327
G alpha (z) signalling events (2) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Gluconeogenesis (9) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (20) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (4) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (3) REACT_16925
Golgi Associated Vesicle Biogenesis (1) REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (1) REACT_1100
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GRB2:SOS provides linkage to MAPK signaling for Integrins (1) REACT_15443
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (2) REACT_9465
Histidine catabolism (4) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Inositol transporters (1) REACT_19188
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (2) REACT_14805
Interleukin receptor SHC signaling (1) REACT_23891
Iron uptake and transport (1) REACT_25060
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (2) REACT_121120
Kinesins (1) REACT_25201
L13a-mediated translational silencing of Ceruloplasmin expression (1) REACT_79
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (4) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
Meiotic recombination (1) REACT_27271
MEK activation (1) REACT_962
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (3) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (4) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Minus-strand DNA synthesis (1) REACT_9055
Miscellaneous substrates (1) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2) REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (3) REACT_150353
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (19) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (6) REACT_25073
mRNA Capping (3) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4) REACT_20518
mTOR signalling (1) REACT_6838
Na+/Cl- dependent neurotransmitter transporters (22) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
NADPH regeneration (1) REACT_16904
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
Neurotransmitter Clearance In The Synaptic Cleft (2) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (6) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
NOSIP mediated eNOS trafficking (1) REACT_12510
NOSTRIN mediated eNOS trafficking (1) REACT_12541
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (7) REACT_22357
Orphan transporters (6) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
p130Cas linkage to MAPK signaling for integrins (1) REACT_15381
p38MAPK events (1) REACT_12065
PAOs oxidise polyamines to amines (2) REACT_505
PCP/CE pathway (1) REACT_172581
PDE3B signalling (1) REACT_1451
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (6) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
PKA activation in glucagon signalling (1) REACT_1946
Plasmalogen biosynthesis (1) REACT_1407
Platelet degranulation (1) REACT_318
PLC beta mediated events (1) REACT_15426
Post-chaperonin tubulin folding pathway (1) REACT_16967
PPARA activates gene expression (3) REACT_116145
PRC2 methylates histones and DNA (1) REACT_200808
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Processive synthesis on the C-strand of the telomere (1) REACT_8027
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (3) REACT_1002
Prostacyclin signalling through prostacyclin receptor (2) REACT_23946
Prostanoid ligand receptors (3) REACT_18425
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (18) REACT_19328
Purine catabolism (13) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7) REACT_1776
Purine salvage (12) REACT_1923
Pyrimidine biosynthesis (6) REACT_21376
Pyrimidine catabolism (13) REACT_1023
Pyrimidine salvage reactions (8) REACT_655
Pyruvate metabolism (1) REACT_2071
RAF activation (1) REACT_2077
RAF phosphorylates MEK (1) REACT_614
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (4) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation by TREX1 (2) REACT_163652
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of ornithine decarboxylase (ODC) (1) REACT_13565
Regulation of PLK1 Activity at G2/M Transition (1) REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (2) REACT_21393
Release of eIF4E (1) REACT_6836
Removal of the Flap Intermediate (4) REACT_70
Removal of the Flap Intermediate from the C-strand (4) REACT_7999
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Respiratory electron transport (2) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Retrograde neurotrophin signalling (1) REACT_12435
Reuptake of GABA (4) REACT_23910
REV-ERBA represses gene expression (1) REACT_118789
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
Ribosomal scanning and start codon recognition (1) REACT_931
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (1) REACT_118659
S6K1-mediated signalling (1) REACT_6754
Scavenging by Class A Receptors (4) REACT_163699
Sema3A PAK dependent Axon repulsion (1) REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (6) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Sialic acid metabolism (2) REACT_200874
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (3) REACT_115810
Stimuli-sensing channels (2) REACT_160189
STING mediated induction of host immune responses (1) REACT_147841
Sulfur amino acid metabolism (8) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (10) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (2) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (4) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (2) REACT_120906
Synthesis of PC (3) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (3) REACT_121280
Synthesis of PI (2) REACT_121000
Synthesis of PIPs at the Golgi membrane (1) REACT_120836
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (9) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (4) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (5) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
Telomere C-strand synthesis initiation (1) REACT_7993
Telomere Extension By Telomerase (1) REACT_7974
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (4) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The proton buffering model (1) REACT_6196
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (3) REACT_15292
Tie2 Signaling (1) REACT_12621
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation by small RNAs (1) REACT_267668
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Translation initiation complex formation (1) REACT_1979
Translocation of GLUT4 to the plasma membrane (2) REACT_147867
Transport of fatty acids (4) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (13) REACT_1206
Transport of nucleotide sugars (3) REACT_22151
Transport of organic anions (3) REACT_23988
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (8) REACT_847
Utilization of Ketone Bodies (2) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (2) REACT_228024
VEGFR2 mediated vascular permeability (4) REACT_228016
Vitamin B1 (thiamin) metabolism (2) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
Xenobiotics (1) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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