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ST001935 Metabolomic profiling of spontaneous macaque model for diabetes mellitusList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (2)
REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (5)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (1)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Adenosine P1 receptors (1)
REACT_18288
Adenylate cyclase activating pathway (1)
REACT_15312
Adrenaline,noradrenaline inhibits insulin secretion (1)
REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1)
REACT_19180
Adrenoceptors (1)
REACT_16927
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
Alpha-oxidation of phytanate (2)
REACT_17003
Amino acid synthesis and interconversion (transamination) (8)
REACT_238
Amino acid transport across the plasma membrane (22)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1)
REACT_22433
Biotin transport and metabolism (2)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1)
REACT_111118
Branched-chain amino acid catabolism (4)
REACT_197
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (3)
REACT_2125
Catecholamine biosynthesis (2)
REACT_15551
Circadian Clock (1)
REACT_24941
Citric acid cycle (TCA cycle) (4)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (6)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (3)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2)
REACT_163862
Coenzyme A biosynthesis (2)
REACT_11218
Collagen biosynthesis and modifying enzymes (2)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (3)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (2)
REACT_6812
Creatine metabolism (7)
REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (18)
REACT_111056
Cysteine formation from homocysteine (3)
REACT_115589
Cytosolic iron-sulfur cluster assembly (1)
REACT_160176
Cytosolic sulfonation of small molecules (3)
REACT_6913
Cytosolic tRNA aminoacylation (18)
REACT_15306
DARPP-32 events (1)
REACT_15334
Defective HLCS causes multiple carboxylase deficiency (1)
REACT_169312
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (4)
REACT_115654
Degradation of GABA (3)
REACT_23964
Digestion of dietary carbohydrate (2)
REACT_9472
Digestion of dietary lipid (6)
REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Endogenous sterols (5)
REACT_13812
Endosomal/Vacuolar pathway (18)
REACT_111168
eNOS activation (4)
REACT_12477
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (18)
REACT_111178
ER Quality Control Compartment (ERQC) (1)
REACT_25091
Estrogen biosynthesis (1)
REACT_11037
Fatty acids (4)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (2)
REACT_1319
FMO oxidises nucleophiles (1)
REACT_13653
Formation of the active cofactor, UDP-glucuronate (1)
REACT_6737
Free fatty acid receptors (6)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (12/13) signalling events (1)
REACT_18407
G alpha (i) signalling events (11)
REACT_19231
G alpha (q) signalling events (11)
REACT_18283
G alpha (s) signalling events (6)
REACT_19327
G alpha (z) signalling events (2)
REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1)
REACT_18274
Glucocorticoid biosynthesis (1)
REACT_11036
Gluconeogenesis (5)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (19)
REACT_6960
Glycogen synthesis (2)
REACT_169208
Glycolysis (1)
REACT_1383
Glyoxylate metabolism (3)
REACT_16925
HCN channels (1)
REACT_75862
HDMs demethylate histones (2)
REACT_228178
Hedgehog 'off' state (1)
REACT_267634
Heme biosynthesis (2)
REACT_9465
Heme degradation (1)
REACT_22297
Histidine catabolism (2)
REACT_1249
HS-GAG biosynthesis (1)
REACT_121248
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (2)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (3)
REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Inositol transporters (1)
REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1)
REACT_25367
Interconversion of polyamines (1)
REACT_14805
Iron uptake and transport (2)
REACT_25060
Keratan sulfate biosynthesis (1)
REACT_121120
Ligand-gated ion channel transport (1)
REACT_25387
Lysine catabolism (3)
REACT_1298
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (2)
REACT_14820
Metabolism of serotonin (1)
REACT_15532
Methionine salvage pathway (3)
REACT_75881
Methylation (4)
REACT_6946
Mineralocorticoid biosynthesis (1)
REACT_11047
Miscellaneous substrates (2)
REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (2)
REACT_150353
Mitochondrial tRNA aminoacylation (18)
REACT_15302
Molybdenum cofactor biosynthesis (3)
REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (20)
REACT_20506
Na+-dependent glucose transporters (1)
REACT_19165
NADPH regeneration (1)
REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (2)
REACT_11213
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
NOSIP mediated eNOS trafficking (1)
REACT_12510
NOSTRIN mediated eNOS trafficking (1)
REACT_12541
Organic anion transport (4)
REACT_22310
Organic anion transporters (3)
REACT_19372
Organic cation transport (3)
REACT_22357
Orphan transporters (7)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
P2Y receptors (1)
REACT_18289
PAOs oxidise polyamines to amines (1)
REACT_505
Passive transport by Aquaporins (1)
REACT_23826
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (6)
REACT_1786
PKA activation (1)
REACT_15530
PKA activation in glucagon signalling (1)
REACT_1946
Plasmalogen biosynthesis (1)
REACT_1407
PPARA activates gene expression (3)
REACT_116145
Presynaptic function of Kainate receptors (1)
REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1)
REACT_25396
Proline catabolism (2)
REACT_1002
Prostanoid ligand receptors (2)
REACT_18425
Proton-coupled monocarboxylate transport (1)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (18)
REACT_19328
Purine catabolism (10)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (9)
REACT_1923
Pyrimidine biosynthesis (6)
REACT_21376
Pyrimidine catabolism (11)
REACT_1023
Pyrimidine salvage reactions (5)
REACT_655
Pyruvate metabolism (1)
REACT_2071
Rap1 signalling (1)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1)
REACT_25302
Recycling of bile acids and salts (7)
REACT_11042
Regulation by TREX1 (1)
REACT_163652
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of insulin secretion (1)
REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1)
REACT_19241
Regulation of thyroid hormone activity (1)
REACT_15297
Removal of the Flap Intermediate (1)
REACT_70
Removal of the Flap Intermediate from the C-strand (1)
REACT_7999
Respiratory electron transport (2)
REACT_22393
Retinoid cycle disease events (3)
REACT_160130
Retinoid metabolism and transport (2)
REACT_24968
Reuptake of GABA (2)
REACT_23910
REV-ERBA represses gene expression (1)
REACT_118789
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (1)
REACT_118659
Scavenging by Class A Receptors (2)
REACT_163699
Serine biosynthesis (4)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (1)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (8)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (6)
REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (2)
REACT_150422
Synthesis of bile acids and bile salts (2)
REACT_11054
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7)
REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of Lipoxins (LX) (1)
REACT_150320
Synthesis of PA (2)
REACT_120906
Synthesis of PC (1)
REACT_121238
Synthesis of PG (2)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (5)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3)
REACT_23824
TET1,2,3 and TDG demethylate DNA (2)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (3)
REACT_160083
Thyroxine biosynthesis (4)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (1)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (1)
REACT_27161
Transport of fatty acids (4)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (10)
REACT_1206
Transport of nucleotide sugars (1)
REACT_22151
Transport of organic anions (7)
REACT_23988
Transport of vitamins, nucleosides, and related molecules (1)
REACT_22285
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (8)
REACT_916
Ubiquinol biosynthesis (1)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Uptake and function of anthrax toxins (1)
REACT_228255
Urea cycle (7)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1)
REACT_24023
VEGFR2 mediated vascular permeability (3)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (1)
REACT_11070
Vitamin D (calciferol) metabolism (1)
REACT_13523
Vitamins (1)
REACT_13450
Vitamins B6 activation to pyridoxal phosphate (2)
REACT_25012
Xenobiotics (1)
REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1)
REACT_118713
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