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ST001937 Comprehensive plasma metabolomics and lipidomics based management of benign and malignant solitary pulmonary nodulesList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1)
REACT_850
Abacavir metabolism (1)
REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (5)
REACT_121117
Acetylation (1)
REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (1)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Adenylate cyclase activating pathway (2)
REACT_15312
Aflatoxin activation and detoxification (3)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
alpha-linolenic acid (ALA) metabolism (1)
REACT_121147
Alpha-oxidation of phytanate (3)
REACT_17003
Amino acid synthesis and interconversion (transamination) (11)
REACT_238
Amino acid transport across the plasma membrane (17)
REACT_13796
Androgen biosynthesis (1)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (14)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (15)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biotin transport and metabolism (2)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1)
REACT_111118
Branched-chain amino acid catabolism (4)
REACT_197
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (3)
REACT_2125
Catecholamine biosynthesis (2)
REACT_15551
Cholesterol biosynthesis (1)
REACT_9405
Circadian Clock (1)
REACT_24941
Citric acid cycle (TCA cycle) (5)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (6)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (1)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Coenzyme A biosynthesis (1)
REACT_11218
Collagen biosynthesis and modifying enzymes (3)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (4)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (4)
REACT_6812
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (1)
REACT_6867
Creatine metabolism (4)
REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (2)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (14)
REACT_111056
Cysteine formation from homocysteine (3)
REACT_115589
Cytosolic tRNA aminoacylation (15)
REACT_15306
DARPP-32 events (1)
REACT_15334
Degradation of cysteine and homocysteine (3)
REACT_115654
Degradation of GABA (5)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Digestion of dietary lipid (2)
REACT_9518
DNA replication initiation (1)
REACT_2244
Downstream TCR signaling (1)
REACT_12555
Endogenous sterols (2)
REACT_13812
Endosomal/Vacuolar pathway (14)
REACT_111168
eNOS activation (1)
REACT_12477
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (14)
REACT_111178
ER Quality Control Compartment (ERQC) (1)
REACT_25091
Ethanol oxidation (1)
REACT_34
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3)
REACT_19193
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
Formation of the active cofactor, UDP-glucuronate (1)
REACT_6737
Free fatty acid receptors (5)
REACT_21268
GABA synthesis (2)
REACT_24020
G alpha (i) signalling events (12)
REACT_19231
G alpha (q) signalling events (8)
REACT_18283
G alpha (s) signalling events (4)
REACT_19327
G alpha (z) signalling events (2)
REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (2)
REACT_18274
Glucocorticoid biosynthesis (1)
REACT_11036
Gluconeogenesis (7)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (16)
REACT_6960
Glycogen synthesis (1)
REACT_169208
Glycolysis (3)
REACT_1383
Glycosphingolipid metabolism (1)
REACT_116105
Glyoxylate metabolism (5)
REACT_16925
HCN channels (1)
REACT_75862
HDMs demethylate histones (2)
REACT_228178
Hedgehog 'off' state (2)
REACT_267634
Heme biosynthesis (2)
REACT_9465
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histidine catabolism (2)
REACT_1249
HIV Transcription Initiation (1)
REACT_6332
Hydroxycarboxylic acid-binding receptors (3)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (2)
REACT_163919
Inositol transporters (1)
REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2)
REACT_25367
Interconversion of polyamines (1)
REACT_14805
ISG15 antiviral mechanism (1)
REACT_115831
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysine catabolism (3)
REACT_1298
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of nucleotides (2)
REACT_1698
Metabolism of polyamines (2)
REACT_14820
Methionine salvage pathway (2)
REACT_75881
Methylation (2)
REACT_6946
Mineralocorticoid biosynthesis (1)
REACT_11047
Minus-strand DNA synthesis (2)
REACT_9055
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2)
REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (2)
REACT_150353
Mitochondrial tRNA aminoacylation (15)
REACT_15302
Molybdenum cofactor biosynthesis (4)
REACT_25073
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (15)
REACT_20506
Na+-dependent glucose transporters (1)
REACT_19165
NADPH regeneration (1)
REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
Nicotinamide salvaging (2)
REACT_11213
Nicotinate metabolism (3)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
Organic anion transport (2)
REACT_22310
Organic anion transporters (4)
REACT_19372
Organic cation transport (1)
REACT_22357
Orphan transporters (2)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
PAOs oxidise polyamines to amines (1)
REACT_505
Passive transport by Aquaporins (1)
REACT_23826
PD-1 signaling (1)
REACT_19324
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (1)
REACT_121256
Phenylalanine and tyrosine catabolism (8)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2)
REACT_150237
PKA activation (2)
REACT_15530
PKA activation in glucagon signalling (2)
REACT_1946
Plasmalogen biosynthesis (2)
REACT_1407
Platelet degranulation (1)
REACT_318
PPARA activates gene expression (1)
REACT_116145
Presynaptic function of Kainate receptors (1)
REACT_21254
Processive synthesis on the C-strand of the telomere (1)
REACT_8027
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1)
REACT_25396
Proline catabolism (2)
REACT_1002
Prostanoid ligand receptors (1)
REACT_18425
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (14)
REACT_19328
Purine catabolism (7)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5)
REACT_1776
Purine salvage (6)
REACT_1923
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (7)
REACT_1023
Pyrimidine salvage reactions (2)
REACT_655
Pyruvate metabolism (2)
REACT_2071
Rap1 signalling (2)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1)
REACT_25302
Recycling of bile acids and salts (3)
REACT_11042
Regulation by TREX1 (1)
REACT_163652
Regulation of insulin secretion (1)
REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1)
REACT_19241
Regulation of ornithine decarboxylase (ODC) (1)
REACT_13565
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Removal of DNA patch containing abasic residue (1)
REACT_2192
Resolution of AP sites via the single-nucleotide replacement pathway (1)
REACT_933
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (1)
REACT_24968
Reuptake of GABA (2)
REACT_23910
REV-ERBA represses gene expression (1)
REACT_118789
RNA Polymerase II HIV Promoter Escape (1)
REACT_6253
RNA Polymerase II Promoter Escape (1)
REACT_2089
RNA Polymerase II Transcription Initiation (1)
REACT_1851
RORA activates circadian gene expression (1)
REACT_118659
Scavenging by Class A Receptors (3)
REACT_163699
Serine biosynthesis (5)
REACT_115789
Serotonin and melatonin biosynthesis (4)
REACT_15439
Sialic acid metabolism (2)
REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sperm Motility And Taxes (1)
REACT_163875
Sphingolipid de novo biosynthesis (4)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
STING mediated induction of host immune responses (1)
REACT_147841
Sulfide oxidation to sulfate (2)
REACT_116010
Sulfur amino acid metabolism (4)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (5)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3)
REACT_11041
Synthesis of Dolichyl-phosphate (1)
REACT_22230
Synthesis of GDP-mannose (1)
REACT_22423
Synthesis of IP2, IP, and Ins in the cytosol (2)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3)
REACT_150420
Synthesis of PC (2)
REACT_121238
Synthesis of PE (2)
REACT_120919
Synthesis of PG (1)
REACT_121280
Synthesis of PI (2)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3)
REACT_150149
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3)
REACT_23824
Telomere C-strand synthesis initiation (1)
REACT_7993
Telomere Extension By Telomerase (1)
REACT_7974
TET1,2,3 and TDG demethylate DNA (3)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (2)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (1)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (1)
REACT_27161
Transport and synthesis of PAPS (1)
REACT_6840
Transport of fatty acids (4)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (2)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5)
REACT_1206
Transport of organic anions (2)
REACT_23988
Tryptophan catabolism (6)
REACT_916
Ubiquinol biosynthesis (1)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Uptake and function of anthrax toxins (2)
REACT_228255
Urea cycle (4)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (2)
REACT_24023
VEGFR2 mediated cell proliferation (1)
REACT_228024
Vitamin B2 (riboflavin) metabolism (1)
REACT_11070
Vitamin C (ascorbate) metabolism (2)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (1)
REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1)
REACT_118713
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