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ST002003 A case-control study on plasma metabolomics analysis in Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Part 4)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (1)
REACT_121388
Abnormal metabolism in phenylketonuria (3)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (3)
REACT_14800
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (15)
REACT_13796
Androgen biosynthesis (1)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (12)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (12)
REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (2)
REACT_197
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Class C/3 (Metabotropic glutamate/pheromone receptors) (5)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Creatine metabolism (4)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (12)
REACT_111056
Cytosolic tRNA aminoacylation (12)
REACT_15306
Degradation of GABA (1)
REACT_23964
Digestion of dietary lipid (1)
REACT_9518
Endosomal/Vacuolar pathway (12)
REACT_111168
eNOS activation (2)
REACT_12477
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (12)
REACT_111178
Estrogen biosynthesis (1)
REACT_11037
FMO oxidises nucleophiles (1)
REACT_13653
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (5)
REACT_19231
G alpha (q) signalling events (5)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
Gluconeogenesis (1)
REACT_1520
Glucuronidation (1)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (12)
REACT_6960
Histidine catabolism (3)
REACT_1249
Hydrolysis of LPC (1)
REACT_120977
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Ligand-gated ion channel transport (1)
REACT_25387
Lysine catabolism (2)
REACT_1298
Lysosphingolipid and LPA receptors (1)
REACT_18365
Metabolism of folate and pterines (1)
REACT_11167
Metabolism of polyamines (2)
REACT_14820
Metabolism of serotonin (1)
REACT_15532
Methionine salvage pathway (2)
REACT_75881
Methylation (2)
REACT_6946
Miscellaneous substrates (2)
REACT_13425
Mitochondrial tRNA aminoacylation (12)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (13)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
Organic anion transport (1)
REACT_22310
Organic anion transporters (1)
REACT_19372
Organic cation transport (6)
REACT_22357
Orphan transporters (1)
REACT_267716
Passive transport by Aquaporins (1)
REACT_23826
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (3)
REACT_1786
Platelet degranulation (1)
REACT_318
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (12)
REACT_19328
Purine catabolism (3)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2)
REACT_1776
Purine salvage (3)
REACT_1923
Pyrimidine biosynthesis (2)
REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Reuptake of GABA (1)
REACT_23910
Role of phospholipids in phagocytosis (1)
REACT_160158
Serine biosynthesis (1)
REACT_115789
Serotonin and melatonin biosynthesis (2)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfur amino acid metabolism (4)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2)
REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (1)
REACT_121238
Synthesis of PG (1)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1)
REACT_150149
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Thyroxine biosynthesis (1)
REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (4)
REACT_1206
Transport of organic anions (1)
REACT_23988
Tryptophan catabolism (4)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (5)
REACT_847
VEGFR2 mediated cell proliferation (1)
REACT_228024
VEGFR2 mediated vascular permeability (2)
REACT_228016
Vitamins B6 activation to pyridoxal phosphate (3)
REACT_25012
Xenobiotics (1)
REACT_13543
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