ST002003 A case-control study on plasma metabolomics analysis in Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Part 4)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (3) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (3) REACT_14800
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (15) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (12) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (12) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (2) REACT_197
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Conjugation of phenylacetate with glutamine (2) REACT_6800
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (12) REACT_111056
Cytosolic tRNA aminoacylation (12) REACT_15306
Degradation of GABA (1) REACT_23964
Digestion of dietary lipid (1) REACT_9518
Endosomal/Vacuolar pathway (12) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (12) REACT_111178
Estrogen biosynthesis (1) REACT_11037
FMO oxidises nucleophiles (1) REACT_13653
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (5) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (1) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (12) REACT_6960
Histidine catabolism (3) REACT_1249
Hydrolysis of LPC (1) REACT_120977
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (2) REACT_1298
Lysosphingolipid and LPA receptors (1) REACT_18365
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (2) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Miscellaneous substrates (2) REACT_13425
Mitochondrial tRNA aminoacylation (12) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (13) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Organic cation transport (6) REACT_22357
Orphan transporters (1) REACT_267716
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Platelet degranulation (1) REACT_318
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (12) REACT_19328
Purine catabolism (3) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (3) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Reuptake of GABA (1) REACT_23910
Role of phospholipids in phagocytosis (1) REACT_160158
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (1) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (4) REACT_1206
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (4) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (5) REACT_847
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
Xenobiotics (1) REACT_13543
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