ST002020 TIPs Metabolomics (urine)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylation (2) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of the phototransduction cascade (1) REACT_163932
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (1) REACT_15312
Advanced glycosylation endproduct receptor signaling (1) REACT_25195
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Alpha-oxidation of phytanate (2) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (9) REACT_238
Amino acid transport across the plasma membrane (23) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (3) REACT_416
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (6) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (5) REACT_2125
Catecholamine biosynthesis (5) REACT_15551
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (1) REACT_9405
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (4) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (7) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (3) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (4) REACT_172744
Conjugation of benzoate with glycine (3) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (3) REACT_6812
Creatine metabolism (8) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (3) REACT_115589
Cytosolic sulfonation of small molecules (7) REACT_6913
Cytosolic tRNA aminoacylation (19) REACT_15306
DARPP-32 events (1) REACT_15334
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (5) REACT_115654
Degradation of GABA (3) REACT_23964
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (1) REACT_163773
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (4) REACT_9518
DNA methylation (2) REACT_267652
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (19) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (3) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (2) REACT_15511
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (19) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FMO oxidises nucleophiles (1) REACT_13653
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (11) REACT_19231
G alpha (q) signalling events (6) REACT_18283
G alpha (s) signalling events (7) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (6) REACT_1520
Glucuronidation (3) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (20) REACT_6960
Glycolysis (4) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (5) REACT_16925
HCN channels (1) REACT_75862
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (1) REACT_267634
Heme biosynthesis (1) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (4) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
Iron uptake and transport (1) REACT_25060
Ligand-gated ion channel transport (2) REACT_25387
Lysine catabolism (3) REACT_1298
Meiotic recombination (2) REACT_27271
Metabolism of folate and pterines (3) REACT_11167
Metabolism of polyamines (4) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (4) REACT_6946
Miscellaneous substrates (1) REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (19) REACT_15302
Molybdenum cofactor biosynthesis (4) REACT_25073
mRNA Capping (2) REACT_1470
Na+/Cl- dependent neurotransmitter transporters (23) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
NoRC negatively regulates rRNA expression (2) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
Organic anion transport (4) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (7) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (4) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (2) REACT_23826
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (7) REACT_1786
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Platelet degranulation (1) REACT_318
PRC2 methylates histones and DNA (2) REACT_200808
Presynaptic function of Kainate receptors (1) REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (1) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (19) REACT_19328
Purine catabolism (9) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (8) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (11) REACT_1023
Pyrimidine salvage reactions (4) REACT_655
Pyruvate metabolism (2) REACT_2071
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recycling of bile acids and salts (5) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Reuptake of GABA (2) REACT_23910
RIP-mediated NFkB activation via ZBP1 (1) REACT_118563
RMTs methylate histone arginines (2) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
Scavenging by Class A Receptors (3) REACT_163699
Scavenging by Class H Receptors (1) REACT_164002
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (4) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (9) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (2) REACT_120906
Synthesis of PC (3) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (3) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (1) REACT_21281
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
Thyroxine biosynthesis (2) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
TRAF6 mediated NF-kB activation (1) REACT_24969
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (14) REACT_1206
Transport of organic anions (3) REACT_23988
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (10) REACT_916
Ubiquinol biosynthesis (3) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (8) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
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