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ST002033 Irradiation causes alterations of polyamine, purine and sulfur metabolism in red blood cells and multiple organs (Feces-part1)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2)
REACT_850
Abacavir metabolism (3)
REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (6)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (2)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Adenosine P1 receptors (1)
REACT_18288
Adrenaline,noradrenaline inhibits insulin secretion (1)
REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1)
REACT_19180
Adrenoceptors (1)
REACT_16927
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
alpha-linolenic acid (ALA) metabolism (1)
REACT_121147
Alpha-oxidation of phytanate (3)
REACT_17003
Amino acid synthesis and interconversion (transamination) (11)
REACT_238
Amino acid transport across the plasma membrane (17)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (16)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (17)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1)
REACT_22433
Biotin transport and metabolism (2)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2)
REACT_111118
Branched-chain amino acid catabolism (3)
REACT_197
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (6)
REACT_15551
Circadian Clock (2)
REACT_24941
Citric acid cycle (TCA cycle) (5)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (2)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (3)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3)
REACT_163862
Coenzyme A biosynthesis (1)
REACT_11218
Collagen biosynthesis and modifying enzymes (3)
REACT_121139
Condensation of Prophase Chromosomes (4)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (7)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (16)
REACT_111056
Cysteine formation from homocysteine (2)
REACT_115589
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (17)
REACT_15306
DARPP-32 events (1)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (3)
REACT_115654
Degradation of GABA (3)
REACT_23964
Digestion of dietary carbohydrate (1)
REACT_9472
Digestion of dietary lipid (1)
REACT_9518
DNA methylation (2)
REACT_267652
Dopamine clearance from the synaptic cleft (1)
REACT_15514
Dopamine Neurotransmitter Release Cycle (1)
REACT_15293
Dopamine receptors (1)
REACT_16968
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Endosomal/Vacuolar pathway (16)
REACT_111168
eNOS activation (3)
REACT_12477
Enzymatic degradation of dopamine by COMT (3)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (2)
REACT_15511
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (16)
REACT_111178
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
formation of the beta-catenin:TCF transactivating complex (2)
REACT_200753
Free fatty acid receptors (6)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (12/13) signalling events (1)
REACT_18407
G alpha (i) signalling events (10)
REACT_19231
G alpha (q) signalling events (10)
REACT_18283
G alpha (s) signalling events (5)
REACT_19327
G alpha (z) signalling events (1)
REACT_19333
Gluconeogenesis (8)
REACT_1520
Glucuronidation (1)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (17)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycogen synthesis (1)
REACT_169208
Glycolysis (4)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
HDMs demethylate histones (2)
REACT_228178
Heme degradation (2)
REACT_22297
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histidine catabolism (2)
REACT_1249
HS-GAG biosynthesis (1)
REACT_121248
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (2)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1)
REACT_25367
Interconversion of polyamines (3)
REACT_14805
Iron uptake and transport (1)
REACT_25060
ISG15 antiviral mechanism (1)
REACT_115831
Keratan sulfate biosynthesis (1)
REACT_121120
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (2)
REACT_121100
Lysine catabolism (3)
REACT_1298
Lysosphingolipid and LPA receptors (1)
REACT_18365
Meiotic recombination (2)
REACT_27271
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of polyamines (5)
REACT_14820
Metabolism of serotonin (2)
REACT_15532
Methionine salvage pathway (2)
REACT_75881
Methylation (4)
REACT_6946
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (17)
REACT_15302
Molybdenum cofactor biosynthesis (4)
REACT_25073
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2)
REACT_20518
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (18)
REACT_20506
NADPH regeneration (1)
REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (3)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
NoRC negatively regulates rRNA expression (2)
REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
Organic anion transport (3)
REACT_22310
Organic anion transporters (5)
REACT_19372
Organic cation transport (7)
REACT_22357
Orphan transporters (2)
REACT_267716
Oxidative Stress Induced Senescence (4)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
PAOs oxidise polyamines to amines (3)
REACT_505
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (6)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
Plasmalogen biosynthesis (1)
REACT_1407
Platelet degranulation (1)
REACT_318
PPARA activates gene expression (2)
REACT_116145
PRC2 methylates histones and DNA (2)
REACT_200808
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (2)
REACT_19348
Proton/oligonucleotide cotransporters (16)
REACT_19328
Purine catabolism (9)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5)
REACT_1776
Purine salvage (8)
REACT_1923
Pyrimidine biosynthesis (6)
REACT_21376
Pyrimidine catabolism (9)
REACT_1023
Pyrimidine salvage reactions (5)
REACT_655
Pyruvate metabolism (2)
REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Recycling of bile acids and salts (2)
REACT_11042
Regulation by TREX1 (2)
REACT_163652
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2)
REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (2)
REACT_70
Removal of the Flap Intermediate from the C-strand (2)
REACT_7999
Respiratory electron transport (1)
REACT_22393
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (2)
REACT_24968
REV-ERBA represses gene expression (2)
REACT_118789
RMTs methylate histone arginines (2)
REACT_228108
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (2)
REACT_118659
Senescence-Associated Secretory Phenotype (SASP) (2)
REACT_169168
Serine biosynthesis (5)
REACT_115789
Serotonin and melatonin biosynthesis (4)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
Sialic acid metabolism (1)
REACT_200874
SIRT1 negatively regulates rRNA Expression (3)
REACT_200827
snRNP Assembly (1)
REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
Sphingolipid de novo biosynthesis (2)
REACT_115810
Stimuli-sensing channels (2)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (6)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (6)
REACT_21330
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of PA (2)
REACT_120906
Synthesis of PC (4)
REACT_121238
Synthesis of PG (2)
REACT_121280
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2)
REACT_23824
TET1,2,3 and TDG demethylate DNA (3)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (2)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (2)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (5)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (2)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (13)
REACT_1206
Transport of nucleotide sugars (1)
REACT_22151
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (8)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (7)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
VEGFR2 mediated cell proliferation (1)
REACT_228024
VEGFR2 mediated vascular permeability (2)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (1)
REACT_11070
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (3)
REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2)
REACT_118713
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