ST002106 Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 1)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (4) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (2) REACT_160183
Abnormal metabolism in phenylketonuria (5) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (3) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (3) REACT_17003
Amino acid synthesis and interconversion (transamination) (11) REACT_238
Amino acid transport across the plasma membrane (18) REACT_13796
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (17) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (17) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1) REACT_121408
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (6) REACT_197
Carnitine synthesis (4) REACT_2125
Catecholamine biosynthesis (4) REACT_15551
Cell redox homeostasis (2) REACT_121394
Cholesterol biosynthesis (2) REACT_9405
Chondroitin sulfate biosynthesis (1) REACT_120989
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (6) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (5) REACT_163862
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (4) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
COX reactions (1) REACT_1396
Creatine metabolism (5) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of particulate exogenous antigens (phagosomes) (1) REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (17) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic sulfonation of small molecules (2) REACT_6913
Cytosolic tRNA aminoacylation (17) REACT_15306
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (2) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (5) REACT_23964
Detoxification of Reactive Oxygen Species (2) REACT_172715
Digestion of dietary lipid (1) REACT_9518
DNA methylation (2) REACT_267652
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Downregulation of SMAD2/3:SMAD4 transcriptional activity (2) REACT_121111
Eicosanoids (1) REACT_13645
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (17) REACT_111168
eNOS activation (4) REACT_12477
Enzymatic degradation of dopamine by COMT (3) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (2) REACT_15511
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (17) REACT_111178
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (1) REACT_34
Fatty acids (3) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (4) REACT_1319
FMO oxidises nucleophiles (1) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
Free fatty acid receptors (5) REACT_21268
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
Galactose catabolism (1) REACT_532
G alpha (i) signalling events (7) REACT_19231
G alpha (q) signalling events (9) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (7) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (18) REACT_6960
Glycogen synthesis (1) REACT_169208
Glycolysis (3) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (2) REACT_228178
Heme biosynthesis (1) REACT_9465
Heme degradation (2) REACT_22297
Histidine catabolism (3) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Iron uptake and transport (1) REACT_25060
Keratan sulfate biosynthesis (2) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (5) REACT_1298
Meiotic recombination (2) REACT_27271
Metabolism of folate and pterines (3) REACT_11167
Metabolism of nucleotides (2) REACT_1698
Metabolism of polyamines (3) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (6) REACT_6946
Mineralocorticoid biosynthesis (2) REACT_11047
Miscellaneous substrates (2) REACT_13425
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (17) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Mtb iron assimilation by chelation (1) REACT_121118
Na+/Cl- dependent neurotransmitter transporters (17) REACT_20506
NADPH regeneration (2) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (6) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
NoRC negatively regulates rRNA expression (2) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (2) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (4) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
P2Y receptors (1) REACT_18289
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (4) REACT_121256
Phenylalanine and tyrosine catabolism (7) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (2) REACT_1407
PPARA activates gene expression (2) REACT_116145
PRC2 methylates histones and DNA (2) REACT_200808
Pregnenolone biosynthesis (1) REACT_11038
Pre-NOTCH Processing in Golgi (2) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (1) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (3) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (17) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (6) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (2) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Regulation by TREX1 (1) REACT_163652
Regulation of HSF1-mediated heat shock response (2) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of thyroid hormone activity (1) REACT_15297
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Respiratory electron transport (1) REACT_22393
Retinoid cycle disease events (2) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
RMTs methylate histone arginines (2) REACT_228108
Role of phospholipids in phagocytosis (2) REACT_160158
RORA activates circadian gene expression (2) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Serine biosynthesis (5) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
Sialic acid metabolism (2) REACT_200874
SIRT1 negatively regulates rRNA Expression (4) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (6) REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (1) REACT_13438
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (6) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (7) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (4) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (2) REACT_150134
Synthesis of 5-eicosatetraenoic acids (3) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2) REACT_150417
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (4) REACT_150420
Synthesis of Lipoxins (LX) (2) REACT_150320
Synthesis of PA (3) REACT_120906
Synthesis of PC (4) REACT_121238
Synthesis of PE (3) REACT_120919
Synthesis of PG (3) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (4) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (4) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (4) REACT_160156
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Thyroxine biosynthesis (3) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (6) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (3) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (6) REACT_847
Utilization of Ketone Bodies (2) REACT_59
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated vascular permeability (3) REACT_228016
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamin D (calciferol) metabolism (1) REACT_13523
Vitamins (1) REACT_13450
Xenobiotics (1) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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